Effects of ginsenosides on regulatory T cell differentiation.

Regulatory T cells (Treg cells) are a subpopulation of T cells defined as CD4Foxp3CD25. They mainly function as immunosuppressive T cells by downregulating the induction and proliferation of effector T cells, but also modulate the immune system by maintaining self-tolerance and preventing autoimmune disease. In this study, the regulatory roles of ginsenosides, one of the active components in ginseng, C.

Contribution of CD24 polymorphisms to autoimmune disease: A meta-analysis.

Purpose: To determine the relationship between two CD24 polymorphisms, rs8734/rs52812045 and rs3838646, and autoimmune disease.

Design: Meta-analysis.

Methods: The Medline, EMBASE, Web of Science, and Cochrane Library databases were searched for studies reporting the association between CD24 polymorphisms and autoimmune disease.

Identification of arylsulfonamides as ExoU inhibitors.

ExoU is a potent virulence factor of Pseudomonas aeruginosa and is considered a potential therapeutic target. In order to discover novel ExoU inhibitors, we screened an in-house chemical library utilizing a yeast-based screening system. Some sulfonamides displayed significant activity without nonspecific cytotoxicity.