Design of a heteroleptic green Ir(iii) complex for eco-friendly solution-processed phosphorescent organic light-emitting diodes with external quantum efficiency exceeding 22.

The development of eco-friendly solution-processed PHOLEDs (s-PHOLEDs) is a significant issue due to the toxicity of halogenated solvents. However, high-performance s-PHOLEDs have predominantly relied on halogenated solvents, owing to their superior ability to dissolve organic materials and facilitate high-quality film formation in the EMLs. To advance the development of eco-friendly s-PHOLEDs, several criteria are required to solve; the development of emitters and host materials having high solubility in eco-friendly solvents and the establishment of optimal conditions for achieving high-quality films, including uniformity, thickness, and morphology.

Trapped-ion based nanoscale quantum sensing.

Recent development of controlling quantum systems has enabled us to utilize the systems for quantum computing, communication, and sensing. In particular, quantum sensing has attracted attention to a broad community of science and technology, as it could surpass classical limitations in measuring physical quantities such as electric and magnetic field with unprecedented precision. Among various physical platforms for quantum sensing, trapped-ion based system possesses several advantages-atomic size, outstanding quantum coherence, and quantum properties.

Advanced Optical Encryption Using Tunable Color and Polarization Separation in In-Situ Polymerized Chiral Liquid Crystals.

With the rapid advancement of modern communication technologies, safeguarding information against forgery and unauthorized access has become increasingly critical, driving interest in advanced optical encryption systems. These systems excel in parallel image data processing, enabling swift detection and verification of sensitive information. However, traditional light-based encoding methods are constrained by their limited dependence on static parameters such as light wavelength and intensity and lack dynamic, reversible adaptability.

Quantifying crowding perception at large events using beacons and surveys.

Given the increasing urban population and frenetic mobility, understanding how individuals perceive crowding at large-scale events is crucial for effective crowd management and safety. This study focuses on Tokyo Big Sight in Japan exhibitions to examine participants' perceptions of peak crowding times, locations, and local density, and compare them with the actual measurements. Our methodology integrated questionnaires with beacon tag data.

Mutation Status in Myelodysplastic Neoplasm and Acute Myeloid Leukemia: Impact of Reclassification Based on the 5th WHO and International Consensus Classification Criteria: A Korean Multicenter Study.

Background: mutations are associated with poor prognosis in myelodysplastic neoplasm (MDS) and AML. The updated 5th WHO classification and International Consensus Classification (ICC) categorize -mutated MDS and AML as unique entities. We conducted a multicenter study in Korea to investigate the characteristics of -mutated MDS and AML, focusing on diagnostic aspects based on updated classifications.

Nonhalogenated Solvent-Processed Efficient Ternary All-Polymer Solar Cells Enabled by the Introduction of a Naphthyloxy Group into the Side Chain of Polymer Donors.

Conjugated polymer donors are crucial for enhancing the power conversion efficiencies (PCEs) in all-polymer solar cells (All-PSCs) in nonhalogenated solvents. In this work, three wide-band-gap polymer donors (Sil-D1, Ph-Sil-D1, and Nap-Sil-D1) based on dithienobenzothiadiazole (DTBT) and benzodithiophene (BDT) donor moieties optimized by side chain engineering were designed and synthesized. Alkyl (Sil-D1), phenyloxy (Ph-Sil-D1), and naphthyloxy (Nap-Sil-D1) alkyl siloxane side chain units were incorporated into these polymer donors, respectively.

Accomplishing High-Performance Organic Solar Sub-Modules (≈55 cm) with >16% Efficiency by Controlling the Aggregation of an Engineered Non-Fullerene Acceptor.

The fabrication of environmentally benign, solvent-processed, efficient, organic photovoltaic sub-modules remains challenging due to the rapid aggregation of the current high performance non-fullerene acceptors (NFAs). In this regard, design of new NFAs capable of achieving optimal aggregation in large-area organic photovoltaic modules has not been realized. Here, an NFA named BTA-HD-Rh is synthesized with longer (hexyl-decyl) side chains that exhibit good solubility and optimal aggregation.

KoNA: Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data.

During the last decade, the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges, including access to human data, as well as transfer, storage, and sharing of enormous amounts of data. To promote data-driven biological research, the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station (K-BDS), which consists of multiple databases for individual data types. Here, we introduce the Korean Nucleotide Archive (KoNA), a repository of nucleotide sequence data.

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML.

In acute myeloid leukemia (AML), genetic mutations distort hematopoietic differentiation, resulting in the accumulation of leukemic blasts. Yet, it remains unclear how these mutations intersect with cellular origins and whether they converge upon similar differentiation patterns. Single-cell RNA sequencing (scRNA-seq) has enabled high-resolution mapping of the relationship between leukemia and normal cell states, yet this application is hampered by imprecise reference maps of normal hematopoiesis and small sample sizes among patient cohorts.

π-Conjugated Polymer with Pendant Side Chains as a Dopant-Free Hole Transport Material for High-Performance Perovskite Solar Cells.

Dopant-free polymeric hole transport materials (HTMs) have attracted considerable attention in perovskite solar cells (PSCs) due to their high carrier mobilities and excellent hydrophobicity. They are considered promising candidates for HTMs to replace commercial Spiro-OMeTAD to achieve long-term stability and high efficiency in PSCs. In this study, we developed BDT-TA-BTASi, a conjugated donor-π-acceptor polymeric HTM.

Pontocerebellar Hypoplasia 7 with Novel Compound Heterozygous Variants of in a Boy with Micropenis, Developmental Delay, and Ataxia: The First Korean Case Report.

Pontocerebellar hypoplasia (PCH) is a rare neurodegenerative disorder characterized by hypoplasia of the pons and cerebellum and global developmental delay. Among several PCH types, PCH7 is a characteristic type that manifests with not only brain lesions but also sexual developmental disorders. The causative gene, , encodes a protein involved in small ribonucleic acid maturation and processing.

FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner.

Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood.

The Prognostic Significance of Leukocyte Count on All-Cause and Cardiovascular Disease Mortality: A Systematic Review and Meta-Analysis.

White blood cells (WBCs) act as mediators of inflammatory responses and are commonly measured in hospitals. Although several studies have reported a relation between WBC count and mortality, no systematic review or meta-analysis has been conducted. This study aimed to identify an association between WBC count and mortality.

Multifunctional Narrow Band Gap Terpolymer-Enabled High-Performance Dopant-Free Perovskite and Additive-Free Organic Solar Cells with Long-Term Stability.

The optoelectronic devices endowing multifunctionality while utilizing a single low-cost material have always been challenging. For this purpose, we adopted a random ternary copolymerization strategy for designing two terpolymers, namely TP-0.8-EG and TP-0.

Introduction of the Korea BioData Station (K-BDS) for sharing biological data.

A wave of new technologies has created opportunities for the cost-effective generation of high-throughput profiles of biological systems, foreshadowing a "data-driven science" era. The large variety of data available from biological research is also a rich resource that can be used for innovative endeavors. However, we are facing considerable challenges in big data deposition, integration, and translation due to the complexity of biological data and its production at unprecedented exponential rates.

Finely Tuned Molecular Packing Realized by a New Rhodanine-Based Acceptor Enabling Excellent Additive-Free Small- and Large-Area Organic Photovoltaic Devices Approaching 19 and 12.20% Efficiencies.

A new nonfullerene acceptor (NFA), BTA-ERh, was synthesized and integrated into a PM6:Y7:PCBM ternary system to regulate the blend film morphology for enhanced device performance. Due to BTA-ERh's good miscibility with host active blend films, an optimized film morphology was obtained with appropriate phase separation and fine-tuning of film crystallinity, which ultimately resulted in efficient exciton dissociation, charge transport, lower recombination loss, and decreased trap-state density. The resulting additive-free quaternary devices achieved a remarkable efficiency of 18.

Investigation of early molecular alterations in tauopathy with generative adversarial networks.

The recent advances in deep learning-based approaches hold great promise for unravelling biological mechanisms, discovering biomarkers, and predicting gene function. Here, we deployed a deep generative model for simulating the molecular progression of tauopathy and dissecting its early features. We applied generative adversarial networks (GANs) for bulk RNA-seq analysis in a mouse model of tauopathy (TPR50-P301S).

Changes in visits to green spaces due to the COVID-19 pandemic: Focusing on the proportion of repeat visitors and the distances between green spaces and visitors' places of residences.

Through a quantitative approach, this study aimed to clarify the changes in the number of visitors and visits to green spaces according to green space type before and after the COVID-19 pandemic. We explored the changes in the proportion of repeat visitors and the distance between green spaces and visitors' places of residence. We used KDDI Location Analyzer, which performs novel analysis using mobile phone GPS and census data.

DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity.

Microglial phagocytosis and clearance are important for the removal of amyloid-β (Aβ) plaques in Alzheimer's disease (AD). Chronic exposure of microglia to Aβ plaques leads to microglial metabolic dysfunction, and dysregulation of microglia can accelerate the deposition of Aβ plaques and cause learning and memory impairment. Thus, regulating microglial Aβ clearance is crucial for the development of therapeutics for AD-related dementia.

Differentiation of industrial hemp strains by their cannabinoid and phenolic compounds using LC × LC-HRMS.

Cannabis is an ancient plant that has been used for therapeutic and recreational purposes. Nowadays, industrial hemp, a variety with low concentration of the psychoactive cannabinoid Δ-tetrahydrocannabinol (THC) and high concentration of non-psychoactive cannabinoids, is getting more and more interest in the food, pharmaceutical, and cosmetic industry. However, cannabis not only contains cannabinoids as bioactive components but also other metabolites like terpenes and phenolic compounds, and the content of these interesting secondary metabolites greatly differs with the genetic variety of the plant.

Impact of Aryl End Group Engineering of Donor Polymers on the Morphology and Efficiency of Halogen-Free Solvent-Processed Nonfullerene Organic Solar Cells.

End group engineering on the side chain of π-conjugated donor polymers is explored as an effective way to develop efficient photovoltaic devices. In this work, we designed and synthesized three new π-conjugated polymers (PBDT-BZ-1, PBDT-S-BZ, and PBDT-BZ-F) with terminal aryl end groups on the side chain of chlorine-substituted benzo[1,2-:4,5']dithiophene (BDT). End group modifications showed notable changes in energy levels, dipole moments, exciton lifetimes, energy losses, and charge transport properties.

VPrimer: A Method of Designing and Updating Primer and Probe With High Variant Coverage for RNA Virus Detection.

Fatal infectious diseases caused by RNA viruses, such as COVID-19, have emerged around the world. RT-PCR is widely employed for virus detection, and its accuracy depends on the primers and probes since RT-PCR can detect a virus only when the primers and probes bind to the target gene of the virus. Most of primer design methods are for a single host and so require a great deal of effort to design for RNA virus detection, including homology tests among the host and all the viruses for the host using BLAST-like tools.

Perceptions and Experiences of Migrants in Korea Regarding Blood Donation in Association with Sociodemographic Status.

Background: With increasing number of migrants in Korea, there is an increasing need for blood products with rare blood antigens. Accordingly, the role of blood donors among migrants has been acknowledged. We investigated migrants' experiences and perceptions of blood donation along with their sociodemographic status and identified the effects on self-reported blood donation status.