Publications by authors named "Hyeong-Dong Yuk"
Background: The effect of anesthesia methods on non-muscle invasive bladder cancer (NMIBC) recurrence post-resection remains uncertain. We aimed to compare the oncological outcomes of spinal anesthesia (SA) and general anesthesia (GA) in patients with NMIBC.
Methods: This prospective randomized controlled trial recruited 287 patients with clinical NMIBC at Seoul National University Hospital from 2018 to 2020.
Background: To compare the efficacy and toxicity of docetaxel treatment regimens in metastatic castration-resistant prostate cancer (mCRPC).
Methods: We retrospectively analyzed 162 patients diagnosed with mCRPC who underwent docetaxel chemotherapy between 2009 and 2020. The patients were divided into three groups according to the dosage and interval of docetaxel (DCT) chemotherapy regimen: 30 mL/m weekly, 50 mL/m biweekly (every 2 weeks), and 75 mL/m triweekly (every 3 weeks).
Article Synopsis
- * PLGA nanoparticles are commonly used for drug delivery but face challenges in controlling size and release, especially when encapsulating negatively charged nucleic acids.
- * This study improves nucleic acid encapsulation using negatively charged microbeads, tests a prostate cancer model with PSMA-617-conjugated PLGA nanoparticles, and suggests a novel method for customizing cancer treatments.
The World Health Organization/International Society of Urological Pathology (WHO/ISUP) grading of renal cell carcinoma (RCC) is classified from grade 1-4, regardless of subtype. The National Comprehensive Cancer Network (NCCN) guidelines (2022) state that if there is an adverse pathological feature, such as grade 3 or higher RCC in stage 1 patients, more rigorous follow-up imaging is recommended. However, the RCC guidelines do not provide specific treatment or follow-up policies by tumor grade.
View Article and Find Full Text PDFPurpose: To investigate if increased tubular damage biomarker can predict pathologically upstaged renal cell carcinoma (RCC), which may possess sub-radiologic invasive behavior, leading to surrounding tubular damage.
Materials And Methods: We examined 1563 patients with surgically resected RCC between March 2016 and June 2021 from the prospective database SUPER-RCC-Nx. Exclusion criteria were cancer not originating from the kidneys, benign renal tumor, and end-stage renal disease.
Article Synopsis
- The study investigates the prognostic significance of lymphatic invasion in prostate cancer, particularly its relationship with biochemical recurrence (BCR) rates in patients who underwent radical prostatectomy (RP) with or without pelvic lymph node dissection (PLND).
- Researchers analyzed data from 2,207 patients without PLND and 742 with PLND, finding that lymphatic invasion occurred in 3.5% of patients without lymph node metastasis, while 47.6% of patients with metastasis had lymphatic invasion.
- Results showed that patients with lymphatic invasion had significantly poorer BCR-free survival compared to those without, but there was no notable survival difference between patients with lymphatic invasion and
Article Synopsis
- The study aimed to compare how different types of urinary diversion (ileal conduit vs. neobladder) affect kidney function in patients with a single kidney who had bladder cancer surgery.
- Researchers assessed kidney function in 86 patients over several months using various methods and found no significant differences in kidney function change between the two urinary diversion types.
- The results suggest that since urinary diversion type did not affect kidney function, patients with a single kidney might be good candidates for neobladder surgery.
Article Synopsis
- A study was conducted on 743 patients who underwent radical nephroureterectomy (RNUx) for upper tract urothelial carcinoma (UTUC) to assess pyuria as a potential predictor of intravesical recurrence (IVR).
- Results showed that patients with pyuria had a significantly shorter IVR-free survival rate (49.7%) compared to those without pyuria (60.0%), with pyuria identified as an independent predictor of IVR (HR=1.368).
- Other factors contributing to IVR risk included concurrent bladder tumors, preoperative ureteroscopy, laparoscopic surgery, tumor multiplicity, and larger tumor size; however, pyuria showed no correlation with
Traditional tissue-based assessments of genomic alterations in castration-resistant prostate cancer (CRPC) can be challenging. To evaluate the real-world clinical utility of liquid biopsies for the evaluation of genomic alterations in CRPC, we preemptively collected available plasma samples and archival tissue samples from patients that were being treated for clinically confirmed CRPC. The cell-free DNA (cfDNA) and tumor tissue DNA were analyzed using the AlphaLiquid100-HRR panel.
View Article and Find Full Text PDFBackground: Clear cell papillary renal cell tumor (CCPRCT) was first reported in 2006 a patient with end stage renal disease. After that it was discovered in the kidney without end stage renal disease in the 2010s and started to be mentioned in pathology and urology. The incidence of CCPRCT is low and most of it is discovered incidentally, so there is a lack of reports on clinical characteristics and surgical outcome.
View Article and Find Full Text PDFBackground: Previous studies using the Vesical Imaging Reporting and Data System (VI-RADS) to predict muscle-invasive bladder cancer (MIBC) had some limitations. Most studies were performed with transurethral resection of bladder tumor (TUR-BT) specimens with few samples. This study was conducted to address these shortcomings and confirm the accuracy of VI-RADS for bladder cancer.
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- This study assesses how urinary retention affects the outcomes of holmium laser enucleation of the prostate (HoLEP) in patients with benign prostatic hyperplasia (BPH) and urinary symptoms.
- A total of 903 patients were analyzed, with follow-up data showing significant improvements in urinary flow and postvoid residual volumes across groups, both with and without histories of urinary retention.
- The findings indicate that patients with preoperative acute or chronic urinary retention experience similar enhancements in voiding symptoms and urinary flow after the procedure compared to those without urinary retention.
Purpose: This study aimed to compare the functional and oncological outcomes of females who underwent uterus-sparing radical cystectomy (USRC) and standard radical cystectomy (SRC).
Materials And Methods: Between February 2009 and December 2020, 90 female patients who underwent radical cystectomy with urinary diversion were included in this study, comprising the USRC and SRC groups. Functional outcomes were assessed in 63 patients who only underwent radical cystectomy with neobladder formation.
Article Synopsis
- The study investigates how pre-operative ipsilateral split renal function (SRF) impacts disease-free survival (DFS) in patients with renal cell carcinoma (RCC) undergoing surgery.
- Out of 1,078 patients, those with decreased SRF exhibited larger tumor sizes, higher Fuhrman grades, and more aggressive tumor stages.
- Analysis indicated that decreased SRF was linked to shorter DFS and presented as a significant risk factor alongside high SSIGN scores, suggesting its importance in assessing prognosis for RCC patients.
Background: Kidney tubular damage markers are biomarkers of acute or chronic kidney injury. Hypothetically, upper tract urothelial cancer (UTUC), which induces obstructive uropathy or direct invasion of the renal parenchyma, may also induce increased excretion of urinary tubular damage proteins. Therefore, this study aimed to investigate the use of tubular damage biomarker as prognostic markers for UTUC.
View Article and Find Full Text PDFPurpose: To assess the prognostic value of acidic urine (low urine pH) in patients with bladder cancer undergoing radical cystectomy.
Materials And Methods: We reviewed patients enrolled in the Seoul National University Prospectively Enrolled Registry for Urothelial Cancer-Cystectomy (SUPER-UC-Cx) who underwent radical cystectomy for bladder cancer between March 2016 and December 2020 at the Seoul National University Hospital. During this period, 368 patients were registered in our database.
Article Synopsis
- Upper tract urothelial carcinoma (UTUC) affects the urothelial cells in the kidney and ureters, and high levels of the tumor marker CA 19-9 are linked to poorer outcomes in cancer patients.
- A study involving 227 patients from Seoul National University found that elevated CA 19-9 levels correlated with higher tumor burdens and worse prognosis regarding metastasis-free and overall survival.
- Additionally, after adjusting for variables, CA 19-9 was identified as an independent prognostic factor for UTUC.
Article Synopsis
- This study investigates the causes of high intrarenal pressure (IRP) during minimally invasive surgery for kidney stones, as excessive IRP can lead to complications due to bacteria absorption.* -
- It analyzed data from 27 patients undergoing mini-PCNL, finding that IRP significantly increased during specific surgical phases like stone fragmentation and upper-pole navigation.* -
- Factors influencing elevated IRP included baseline pressure, surgical technique, number of stones, and laser settings; the study suggests table tilting may help manage IRP in some cases.*
Background: Non-muscle invasive bladder cancer can be controlled by transurethral resection of bladder (TURB), but suffers from frequent recurrences in 60-70% of cases. Although, recurrence interval after TURB influences treatment course and prognosis, its implication and risk factors have not been fully elucidated. We evaluated the risk factors of early (within 1 yr) and late (after 1 yr) recurrence of pTa bladder cancer and clinical significance of recurrence interval on disease progression and overall survival.
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- The study aimed to demonstrate the effectiveness of percutaneous embolization as a treatment for persistent urine leakage following orthotopic neobladder formation, using a mixture of N-butyl cyanoacrylate and lipiodol.
- Five patients out of 182 who underwent this medical procedure experienced successful resolution of their urine leakage, with a median time of 55 days for closure.
- Complications were minimal, with two patients developing bladder stones, but overall quality of life scores remained stable throughout the follow-up period.
Purpose: To demonstrate the safety and feasibility of synchronous unilateral nephrectomy and contralateral heminephrectomy in extremely severe autosomal dominant polycystic kidney disease (ADPKD), which corresponds to the Mayo imaging classification classes 1D and 1E.
Materials And Methods: We retrospectively reviewed patients who underwent unilateral nephrectomy and contralateral heminephrectomy at the Seoul National University Hospital (Seoul, Korea) between May 1, 2016 and August 1, 2021. The preoperative kidney volume was calculated using the ellipsoid equation (length×width×thickness×π/6).
We evaluated the contribution of tumor volume (TV) to localized prostate cancer (PCa) patients' prognosis. We retrospectively analyzed the data of 2394 patients who underwent radical prostatectomy (RP) for localized PCa. The effect of TV and tumor prostate ratio (TV/PV) on PCa patients' prognosis was analyzed through Kaplan-Meier and Cox-proportional analysis.
View Article and Find Full Text PDFPurpose: To assess the prognostic role of acidic urine (low urine pH) in upper tract urothelial cancer (UTUC).
Materials And Methods: We reviewed patients enrolled in Seoul National University Prospectively Enrolled Registry for Urothelial Cancer-Upper Tract Urothelial Cancer (SUPER-UC-UTUC) who underwent surgical resection from March 2016 to December 2020 in Seoul National University Hospital (SNUH). Patients with non-urothelial cancer or those who are in condition at end-stage renal disease were excluded.
Article Synopsis
- The study aimed to compare the G8 assessment and the Charlson Comorbidity Index (CCI) in predicting postoperative complications for older adults (≥65 years) undergoing major uro-oncologic surgeries.
- It analyzed data from 657 patients, showing that those with G8 scores ≤14 faced significantly higher complication rates than those with scores >14, indicating G8's effectiveness as a predictive tool.
- The findings suggest that older patients with G8 scores <10 should be carefully counseled due to a very high risk of surgical complications, highlighting the need for detailed geriatric assessments prior to surgery.
Several studies founded that preoperative renal insufficiency is associated with a higher risk of upper tract urothelial carcinoma recurrence and mortality than normal renal function patients. However, previous studies were all retrospective; no study focused on urothelial carcinoma in the bladder and metastasis-free survival (MFS). Herein, we examined the prognostic impact of preoperative renal insufficiency on the oncologic outcomes of patients with urothelial carcinoma in the bladder after radical cystectomy.
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