HfO-based ferroelectric synaptic devices: challenges and engineering solutions.

HfO-based ferroelectric memories have garnered significant attention for their potential to serve as artificial synaptic devices owing to their scalability and CMOS compatibility. This review examines the key material properties and challenges associated with HfO-based ferroelectric artificial synaptic devices as well as the recent advancements in engineering strategies to improve their synaptic performance. The fundamental physics and material properties of HfO-based ferroelectrics are reviewed to understand the theoretical origin of the aforementioned technical issues in ferroelectric HfO-based synaptic devices.

Update on Resection Strategies for Hepatocellular Carcinoma: A Narrative Review.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, the incidence of which is rising globally. Despite recent advancements in immunotherapeutic and surgical treatment modalities, the prognosis for HCC remains poor. The surgical treatment strategy for HCC comprises a multimodal effort that ranges from ablative therapy and surgical resection to liver transplantation.

Understanding the electric field dependent channel migration for shorter channel length of multilayer rhenium disulfide (ReS) FETs.

Multilayer rhenium disulfide (ReS) has attracted considerable attention due to the decoupled van der Waals interaction between its adjacent layers, leading to significantly higher interlayer resistance compared with other layered materials. While the carrier transport in multilayer materials can be well described by the interlayer resistance () and Thomas-Fermi charge screening length (λTF) in resistor network models, the electric field scaling of the channel with the back gate voltage () and the drain voltage () is limited in two-dimensional (2D) multilayer materials. In this report, we present the effects ofandon the channel migration of ReSfield effect transistors (FETs) with channel lengths of 0.

Inhibition of Epithelial-Mesenchymal Transition and Migration in Cisplatin-resistant Cancer Through Combined Treatment With Cisplatin and SH003.

Background/aim: This study investigated the synergistic effects of combining cisplatin and SH003 treatment on the viability, apoptosis, cytotoxicity, migration and epithelial-mesenchymal transition (EMT) in cisplatin-resistant cancer cell lines YD-8/CIS, YD-9/CIS and YD-38/CIS.

Materials And Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess cell viability, while trypan blue exclusion assay was used to evaluate cytotoxicity. Flow cytometry and western blot analysis measured apoptotic cell death.

Integrating Social Drivers of Health into Hospital Ratings with Application to the 100 Top Hospitals Study.

The objective was to investigate the relationship between social drivers of health (SDOH) and hospital performance within the 100 Top Hospitals study, exploring methods to recognize hospitals serving marginalized communities. Publicly available data sourced from the Centers for Medicare and Medicaid Services and the 2023 100 Top Hospitals study was used. The study employed multivariable hierarchical generalized linear regression models to assess the association between an SDOH composite variable derived using principal component analysis and overall hospital performance measures within the 100 Top Hospitals study.

A novel method for rapid estimation of active bone marrow dose for radiotherapy patients in epidemiological studies.

Background: In a dedicated effort to improve the assessment of clonal hematopoiesis (CH) and study leukemia risk following radiotherapy, we are developing a large-scale cohort study among cancer patients who received radiation. To that end, it will be critical to analyze dosimetric parameters of red bone marrow (ABM) exposure in relation to CH and its progression to myeloid neoplasms, requiring reconstruction method for ABM doses of a large-scale patients rapidly and accurately.

Purpose: To support a large-scale cohort study on the assessment of clonal hematopoiesis and leukemia risk following radiotherapy, we present a new method for the rapid reconstruction of ABM doses of radiotherapy among cancer patients.

Review on recent advances in cellulose nanofibril based hybrid aerogels: Synthesis, properties and their applications.

With the depletion of fossil fuels and growing environmental concerns, the modernized era of technology is in desperate need of sustainable and eco-friendly materials. The industrial sector surely has enough resources to produce cost-effective, renewable, reusable, and sustainable raw materials. The family of very porous solid materials known as aerogels has a variety of exceptional qualities, such as high porosity, high specific surface area, ultralow density, and superior thermal, acoustic, and dielectric properties.

Swyer Syndrome: A Case Report.

Swyer syndrome is a rare form of primary amenorrhea resulting from gonadal dysgenesis. It is characterized by the presence of a female phenotype with a 46, XY karyotype. In our case, CT scans revealed the absence of the uterus and bilateral ovaries of the 16-year-old female patient.

The Protective Effects of Moisturizer Containing Extract in the Topical Treatment of Skin Damage Caused by Masks.

The use of face masks during the COVID-19 pandemic resulted in significant societal changes, particularly for individuals with sensitive skin. To address this issue, the researchers explored traditional medicine and identified extract as a potential solution due to its anti-inflammatory and moisturizing effects. This research investigated how this extract influences skin hydration, barrier function, and itching.

Recent advances in the development of MXenes/cellulose based composites: A review.

Over the past few years, transition metal carbides, nitrides, and carbonitrides, commonly referred to as MXenes have been discovered and utilized quickly in a range of technical fields due to their distinctive and controlled characteristics. MXenes are a new class of two-dimensional (2D) materials that have found extensive use in a variety of fields, including energy storage, catalysis, sensing, biology, and other scientific disciplines. This is because of their exceptional mechanical and structural characteristics, metal electrical conductivity, and other outstanding physical and chemical properties.

Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the locus.

Background: The incorporation of co-stimulatory signaling domains into second-generation chimeric antigen receptors (CARs) significantly enhances the proliferation and persistence of CAR-T cells in vivo, leading to successful clinical outcomes.

Methods: To achieve such functional enhancement in transgenic T-cell receptor-engineered T-cell (TCR-T) therapy, we designed a second-generation TCR-T cell in which CD3ζ genes modified to contain the intracellular domain (ICD) of the 4-1BB receptor were selectively inserted into the locus.

Results: This modification enabled the simultaneous recruitment of key adaptor molecules for signals 1 and 2 on TCR engagement.

Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells.

Introduction: Although the engineering of T cells to co-express immunostimulatory cytokines has been shown to enhance the therapeutic efficacy of adoptive T cell therapy, the uncontrolled systemic release of potent cytokines can lead to severe adverse effects. To address this, we site-specifically inserted the (IL-12) gene into the PDCD1 locus in T cells using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-based genome editing to achieve T-cell activation-dependent expression of IL-12 while ablating the expression of inhibitory PD-1.

Methods: New York esophageal squamous cell carcinoma 1(NY-ESO-1)-specific TCR-T cells was investigated as a model system.

Recent advances in the hybridization of cellulose and semiconductors: Design, fabrication and emerging multidimensional applications: A review.

Cellulose is a plentiful, biodegradable, renewable, and natural polymer in the world that can be widely utilized in the production of polymer nanocomposites. Cellulose is developed in nanomaterials owing to its remarkable inherent features of low density, non-toxicity, and affordability, as well as the amazing sample characteristics of strength and thermal stability. Recently, there has been a lot of interest in organic-inorganic composites because of their adaptable qualities.

Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein.

Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against Aβ have been shown to substantially reduce Aβ burden in patients with AD, their effects on improving cognitive function remain marginal. In addition, a significant portion of patients treated with Aβ-targeting antibodies experience brain edema and microhemorrhage associated with antibody-mediated Fc receptor activation in the brain.

Full etiologic spectrum of pediatric severe to profound hearing loss of consecutive 119 cases.

Determining the etiology of severe-to-profound sensorineural hearing loss (SP-SNHL) in pediatric subjects is particularly important in aiding the decision for auditory rehabilitation. We aimed to update the etiologic spectrum of pediatric SP-SNHL by combining internal auditory canal (IAC)-MRI with comprehensive and state-of-the-art genetic testings. From May 2013 to September 2020, 119 cochlear implantees under the age of 15 years with SP-SNHL were all prospectively recruited.

Assessing Gene Expression Related to Cisplatin Resistance in Human Oral Squamous Cell Carcinoma Cell Lines.

Cisplatin-based chemotherapy has been effectively used to treat oral cancer, but treatment often fails owing to the development of drug resistance. However, the important gene expression alterations associated with these resistances remain unclear. In this study, we aimed to identify the gene expressions related to cisplatin resistance in oral squamous cell carcinoma (OSCC) cell lines.

The Effect of Extracellular Vesicles from Korean Women in Their 20s on Skin Aging.

Extracellular vesicles, which are highly conserved in most cells, contain biologically active substances. The vesicles and substances interact with cells and impact physiological mechanisms. The skin is the most external organ and is in direct contact with the external environment.

Evaluation of Touch and Durability of Cotton Knit Fabrics Treated with Reactive Urethane-Silicone Softener.

A new reactive urethane-silicone softener was developed to provide a soft touch to cotton knit fabrics with improved durability to washing and dimensional stability. The reactive urethane-silicone softener consisted of an amino silicone softener and a blocked isocyanate, which can crosslink and react with cellulose surfaces. The activated isocyanate from the blocked isocyanate reacted with the amino silicone softener by heat treatment at 150 °C for 30 min.

Design and evaluation of 3D-printed auxetic structures coated by CWPU/graphene as strain sensor.

A strain sensor characterized by elasticity has recently been studied in various ways to be applied to monitoring humans or robots. Here, 4 types of 3D-printed auxetic lattice structures using thermoplastic polyurethane as raw material were characterized: truss and honeycomb with positive Poisson's ratio and chiral truss and re-entrant with negative Poisson's ratio. Each structure was fabricated as a flexible and stable strain sensor by coating graphene through a dip-coating process.

The Formation and Invariance of Canine Nose Pattern of Beagle Dogs from Early Puppy to Young Adult Periods.

The formation and invariance of the canine nose pattern is studied. Nose images of ten beagle dogs were collected for ten months from month two to month eleven. The nose patterns in these images are examined visually and by a biometric algorithm.