Publications by authors named "Hyeon-Kyoung Lee"
Article Synopsis
- * Sinkihwan-gamibang (SKHGMB), from traditional Chinese medicine, was studied for its effects on kidney dysfunction in a rat model of NS induced by puromycin aminonucleoside (PAN).
- * The study found that SKHGMB reduced kidney size, proteinuria, and fluid retention while improving kidney function markers, indicating its potential to combat renal inflammation and fibrosis in NS.
Article Synopsis
- Diabetic cardiovascular dysfunction is a serious complication of type 2 diabetes, driven by inflammation and myocardial fibrosis, leading to heart structure and function issues.
- A study compared different mouse groups, including those with type 2 diabetes, and found that blackcurrant extract (Bla.C) improved blood sugar levels and heart function, reducing biomarkers for fibrosis and inflammation.
- The findings suggest that Bla.C may help prevent cardiovascular complications in diabetes by addressing inflammation and improving overall heart health, highlighting its potential therapeutic value.
Article Synopsis
- Renal ischemia-reperfusion (I/R) injury is a significant cause of acute renal failure, and the study investigates the effects of Geumgwe-sinkihwan (GSH), a traditional Chinese medicine, on a mouse model of this condition.
- The experiment involved administering different doses of GSH to mice after inducing I/R injury through surgical clamping of renal arteries, revealing that GSH improves kidney function and reduces markers of renal injury.
- The results showed that GSH decreases inflammatory cytokines and inflammasome-related proteins, suggesting its potential as a therapeutic agent to mitigate renal damage and inflammation in cases of acute renal failure.
Abnormal and excessive growth of mesangial cells is important in the pathophysiologic processes of diabetes-associated interstitial fibrosis and glomerulosclerosis, leading to diabetic nephropathy, which eventually turns into end-stage renal disease. Sauchinone, a biologically-active lignan isolated from aerial parts of , has anti-inflammatory and anti-viral activities effects on various cell types. However, there are no studies reporting the effects of sauchinone on diabetic nephropathy.
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