Publications by authors named "Hyeon-A Song"
Article Synopsis
- - The immune system relies on both innate and adaptive responses to fight pathogens, and individuals with weakened immune systems require effective methods to enhance their immune function.
- - This study investigates the effects of the probiotic OTG1204 on macrophages, crucial for immune defense, specifically examining its potential to stimulate the immune response in conditions of immunosuppression induced by cyclophosphamide (CTX).
- - Results showed that OTG1204 activated macrophages, increasing important signaling molecules and cytokines through specific pathways, and helped restore immune function in immunosuppressed mice by improving immune cell populations and overall health indicators.
Hydrangenol, a dihydroisocoumarin, isolated from the leaves of Hydrangea serrata, possesses anti-inflammatory, anti-obesity, and anti-photoaging activities. In this study, we investigated the protective effects of hydrangenol (HG) against lipopolysaccharide (LPS)-induced endotoxemia and elucidated the underlying molecular mechanisms of action in C57BL/6 mice. Oral administration of HG (20 or 40 mg/kg) significantly restored the survival rate and population of macrophages, T helper cells (CD3/CD4), and Th17 cells (CD3/CD4/CCR6) in the spleens of mice with LPS-induced endotoxemia.
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- Many common pain management drugs, like acetaminophen and opioids, have side effects that can't be ignored, prompting researchers to explore new combinations for more effective treatments.
- The study focused on DW-1021, a combination of the NSAID pelubiprofen and the opioid tramadol, to see if it could provide better pain relief and anti-inflammatory effects compared to using either drug alone.
- Results showed that DW-1021 had strong pain-relieving effects and was particularly effective in reducing inflammation, suggesting it could be a promising new option for treating pain and inflammation.