Cp*Co(III)-Catalyzed γ-Selective C-H Allylation/Hydroamination Cascade for the Synthesis of Dihydroisoquinolines.

A Cp*Co(III)-catalyzed γ-selective C-H allylation/hydroamination cascade toward the synthesis of 3,4-dihydroisoquinolines (DHIQs) has been successfully developed, starting from NH ketimines and allyl carbonates. Notably, highly efficient and γ-selective C-H allylations were accomplished using γ-substituted allyl reagents, thus overcoming the issues of poor α/γ selectivity and low reactivity of previous transition metal-catalyzed C-H allylations. The stereochemistry of allyl carbonates was a crucial factor, and synthesis of the DHIQs was achieved using ()-allyl carbonates.

[Clinical features and therapeutic responses of perianal lesions in Crohn's disease].

Background/aims: The aim of this study was to assess the clinical features and therapeutic responses of perianal lesions in Crohn's disease.

Methods: We retrospectively reviewed medical records of 94 cases with perianal lesions among 231 cases registered as Crohn's disease in Seoul National University Hospital between January 1975 and June 2001. The cases were investigated after dividing into two different groups.