Materials design and characterization of injectable and degradable oxidized alginate PANI:PSS hydrogels for photothermal therapy.

Photothermal therapy has gained great attention as an alternative candidate for radiation therapy or chemotherapy for cancers. However, photothermal agents for photothermal therapy are generally in the form of nanoparticles that are too small to remain in the target tissue, and therefore, the agents are rather quickly removed from the targeted site. Furthermore, conventional photothermal agents are generally expensive or complicated to synthesize.

Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency.

Background: Targetable molecular drivers of gastric cancer (GC) metastasis remain largely unidentified, leading to limited targeted therapy options for advanced GC. We aimed to identify molecular drivers for metastasis and devise corresponding therapeutic strategies.

Methods: We performed an unbiased in vivo genome-wide CRISPR/Cas9 knockout (KO) screening in peritoneal dissemination using genetically engineered GC mouse models.

Association of functional sequence variants of the gene with muscle collagen content in pigs.

This study examined the association between functional sequence variants (FSVs) of () genotypes and collagen content in a Landrace and Jeju native pig (JNP) crossbred population. Four muscles (, , , and ) were used for the analysis of meat collagen content, and the same animals were genotyped for the FSVs of the gene by using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Three FSVs of genotypes were identified and had genotype frequencies of 0.

High strength nanostructured Al-based alloys through optimized processing of rapidly quenched amorphous precursors.

We report the methods increasing both strength and ductility of aluminum alloys transformed from amorphous precursor. The mechanical properties of bulk samples produced by spark-plasma sintering (SPS) of amorphous Al-Ni-Co-Dy powders at temperatures above 673 K are significantly enhanced by in-situ crystallization of nano-scale intermetallic compounds during the SPS process. The spark plasma sintered AlNiCoDy bulk specimens exhibit 1433 MPa compressive yield strength and 1773 MPa maximum strength together with 5.