Anti-Inflammatory Activity of Biotransformed Root Extracts Containing 3--β-D-Glucopyranosyl Platycosides in LPS-Stimulated Alveolar Macrophages, NR8383 Cells.

Acute lung injury (ALI) is a severe inflammatory condition characterized by excessive immune responses and oxidative stress, leading to significant tissue damage. Given the need for novel therapeutic agents, this study aimed to explore the anti-inflammatory activity and mechanisms of biotransformed root extracts (BT-PGR), which were enzymatically processed using rapidsase PL Classic from . The goal was to assess the potential of BT-PGR as a natural treatment for ALI.

Inhibitory Activity of on the Lipid Accumulation through Suppressing Adipogenesis and Activating Lipolysis in 3T3-L1 Cells.

(SL) has been reported to exhibit anti-obesity effects in high-fat diet animal models, yet research into its mechanisms of action remains limited. Therefore, this study aimed to elucidate the mechanisms behind the anti-obesity activity of SL's 30% ethanol extract (SL30E) using 3T3-L1 cells in an in vitro setting. SL30E effectively mitigated the accumulation of lipid droplets and triacylglycerol.

Immunostimulatory activity of the aqueous extract from the leaves of subsp. through TLR4‑dependent JNK activation in RAW264.7 cells.

subsp. (SRP) is an endemic plant of Korea, exclusively found on Ulleungdo Island. SRP is widely used as both a traditional medicine and food source.

Anti‑obesity and immunostimulatory activity of in mouse preadipocytes 3T3‑L1 cells and mouse macrophage RAW264.7 cells.

(CF) is known for its anti-inflammatory, antioxidant and antibacterial activities. However, there is a lack of research on its other pharmacological properties. In the present study, the bifunctional roles of CF in 3T3-L1 and RAW264.

Anti-Obesity Effects of Branches in Mouse Adipocytes, 3t3-l1 Cells, and High-Fat Diet Obese Mice.

has been reported to have various pharmacological activities, but most studies were done with its fruits. However, from an economic point of view, the use of discarded leaves and branches as by-products is very valuable. In this study, the and anti-obesity activities of branch extract (HDB) were investigated to evaluate the applicability of HDB as an anti-obesity agent.

Inhibition of lipid droplet accumulation by by suppressing adipogenesis and inducing lipolysis, thermogenesis and autophagy in 3T3‑L1 cells.

It has been reported that exhibits anti-obesity effects in animal models induced by a high-fat diet. However, research on how exerts its anti-obesity effects is currently limited. Thus, the present study focused on identifying the mechanism of action associated with the anti-obesity activity of aerial part (SNAP), which significantly inhibited the accumulation of lipid droplets in differentiating 3T3-L1 cells.

root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3‑L1 cells.

Obesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer. The present study aimed to identify the mechanism of action related to the anti‑obesity activity of root (PLR) based on its effects on lipid droplet accumulation. The inhibitory activity on lipid accumulation was analyzed through Oil‑Red O staining, and the changes in levels of lipid accumulation‑related proteins were analyzed using Western blot analysis.

Immunostimulatory and anti‑obesity activities of leaves in RAW264.7 and 3T3‑L1 cells.

The present study investigated the immunostimulatory activity and anti-obesity activity of leaf extracts (AHL) in RAW264.7 cells and 3T3-L1 cells. AHL increased the production of immunostimulatory factors, such as NO, inducible nitric oxide synthase (iNOS), IL-1β, IL-6 and TNF-α and activated the phagocytotic activity in RAW264.

Immunostimulatory Activity of Leaves through Macrophage Activation and Macrophage Autophagy in Mouse Macrophages, RAW264.7 Cells.

(SP) is a traditional medicinal plant. SP has been reported to have anti-inflammatory, anticancer, and anti-human immunodeficiency virus (HIV) activities. However, there is currently no research available on the immunostimulatory activity of SP.