Publications by authors named "Hyeok Huh"
Background: The association between visit-to-visit blood pressure (BP) variability and dementia risk in chronic kidney disease (CKD) patients has rarely been studied.
Methods: In this retrospective observational study, individuals who received three or more general health screenings were identified in the nationwide database of Korea. Those with persistent non-dialysis-dependent CKD [estimated glomerular filtration rate (eGFR) <60 mL/min/1.
The kidney is a vital organ with diverse biological effects and the burden of kidney function impairment is increasing in modern medicine. As the effects from kidney function on diverse biochemical parameters are yet fully understood, additional investigation to reveal the causal effects is warranted. Here we show the causal estimates from kidney function parameter, estimated glomerular filtration rate (eGFR), on 60 biochemical parameters by performing two-sample Mendelian randomization (MR) study in 337,138 white British UK Biobank participants.
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- Researchers analyzed tubulointerstitial tissue from 65 glomerulonephritis cases using RNA sequencing to identify potential biomarkers related to kidney injury.
- They discovered that DUSP1 gene had consistently low expression across various kidney diseases and may play a critical role in inflammation response.
- Experimental validation showed that increasing DUSP1 reduced inflammatory markers, and combining DUSP1 overexpression with low-dose corticosteroids was more effective in controlling inflammation than using higher doses alone.
Background: Previous observational studies suggested that a reduction in estimated glomerular filtration rate (eGFR) or a supranormal eGFR value was associated with adverse cardiovascular risks. However, a previous Mendelian randomization (MR) study under the linearity assumption reported null causal effects from eGFR on myocardial infarction (MI) risks. Further investigation of the nonlinear causal effect of kidney function assessed by eGFR on the risk of MI by nonlinear MR analysis is warranted.
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