Oil Palm Phenolics Inhibit the Aggregation of -Amyloid Peptide into Oligomeric Complexes.

Alzheimer's disease is a severe neurodegenerative disease characterized by the aggregation of amyloid- peptide (A) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation. Multiple studies show that the soluble oligomers of A42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic. We show that A42 aggregation is inhibited by oil palm phenolics (OPP), an aqueous extract from the oil palm tree .