Publications by authors named "Hye-Jin Hur"
Human embryonic stem cell (hESC)-derived midbrain dopaminergic (mDA) cell transplantation is a promising therapeutic strategy for Parkinson's disease (PD). Here, we present the derivation of high-purity mDA progenitors from clinical-grade hESCs on a large scale under rigorous good manufacturing practice (GMP) conditions. We also assessed the toxicity, biodistribution, and tumorigenicity of these cells in immunodeficient rats in good laboratory practice (GLP)-compliant facilities.
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- Previous studies indicate that transplanting neural precursor cells (NPCs) can protect brain cells and improve recovery in ischemic stroke models through their secreted factors.
- In this study, researchers tested the effects of conditioned medium from NPCs (NPC-CMs) on rats with induced strokes and found that both single and multiple NPC-CM injections led to significant behavioral improvements and reduced brain damage.
- Proteomics and transcriptomics analyses revealed proteins and genes related to nerve development and inflammation, confirming the potential of NPC-CMs as a novel therapeutic approach for stroke treatment.
X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a progressive neurodegenerative disorder associated with the accumulation of very long-chain fatty acids (VLCFA). Cerebral inflammatory demyelination is the major feature of childhood cerebral ALD (CCALD), the most severe form of ALD, but its underlying mechanism remains poorly understood. Here, we identify the aberrant production of cholesterol 25-hydroxylase (CH25H) and 25-hydroxycholesterol (25-HC) in the cellular context of CCALD based on the analysis of ALD patient-derived induced pluripotent stem cells and ex vivo fibroblasts.
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