Publications by authors named "Hye-In Jeon"
The serine protease inhibitor Rv3364c of (MTB) is highly expressed in cells during MTB exposure. In this study, we showed that the WLVSKF motif of Rv3364c interacts with the BAR domain of SNX9 and inhibits endosome trafficking to interact with p47phox, thereby suppressing TLR4 inflammatory signaling in macrophages. Derived from the structure of this Rv3364c peptide motif, 2,4-diamino-6-(4--butylphenyl)-1,3,5-trazine, as a WLVSKF peptide-mimetic small molecule has been identified.
View Article and Find Full Text PDFThe run/cysteine-rich-domain-containing Beclin1-interacting autophagy protein (Rubicon) is essential for the regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by interacting with p22phox to trigger the production of reactive oxygen species (ROS) in immune cells. In a previous study, we demonstrated that the interaction of Rubicon with p22phox increases cellular ROS levels. The correlation between Rubicon and mitochondrial ROS (mtROS) is poorly understood.
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- MTB, the bacteria that causes tuberculosis, uses specific proteins (MPT63 and MPT64) to evade the host's immune system and promote its survival.
- Researchers discovered that these proteins interact with key immune proteins (TBK1, p47phox, and HK2) and created a multifunctional recombinant protein (rMPT) that enhances immune responses and fights MTB.
- The study demonstrated that rMPT not only increases inflammation and reactive oxygen species but also shows potential as a vaccine or treatment against tuberculosis based on tests in mouse models.
Article Synopsis
- Dense granule proteins (GRAs), particularly GRA9, play a crucial role in the host's immune response and may serve as diagnostic markers for toxoplasmosis.
- The study revealed that GRA9 interacts with NLRP3 to influence inflammation, with the C-terminal region of GRA9 (GRA9C) being vital for this interaction and preventing inflammasome formation.
- Recombinant GRA9C (rGRA9C) demonstrated anti-inflammatory effects and enhanced the ability of macrophages to eliminate bacteria, suggesting it could be a promising therapeutic option for treating sepsis.