Publications by authors named "Hye Yun Park"
Article Synopsis
- The study investigates the relationship between preserved ratio impaired spirometry (PRISm) and mortality rates in individuals over 40 years old who underwent health screenings from 2003 to 2020.
- Participants were divided into three groups based on lung function: normal, PRISm with normal forced vital capacity (FVC), and PRISm with low FVC.
- Results show that individuals with PRISm, especially those with low FVC, have a significantly higher risk of death compared to those with normal lung function.
Article Synopsis
- * The study involved 1,526 COPD patients who began MVPA and 4,516 who did not, revealing significant decreases in future inhaled corticosteroid (ICS) usage (HR 0.83) and severe exacerbations (HR 0.81) for those who engaged in MVPA over a median follow-up of 3 years.
- * Results were consistent across various demographics, suggesting that adding MVPA to their treatment could enhance health outcomes for
Article Synopsis
- - A study created a detailed map of the airway cells in patients with pulmonary long COVID, focusing on those who have persistent respiratory symptoms after a COVID-19 infection.
- - Participants with long COVID were compared to those whose symptoms had resolved or who had never been infected, with analysis revealing unique neutrophil clusters in the long COVID group.
- - The findings suggest that increased inflammation and changes in airway cell function, particularly involving neutrophils, may be responsible for the lingering respiratory issues seen in long COVID patients.
Importance: Emerging evidence suggests that wearable devices are feasible for monitoring physical activity among patients with lung cancer. However, the association between wearable devices and improvement in patient recovery after surgery remains underexplored.
Objective: To evaluate the effects of a wearable device intervention on the recovery of physical activity, cardiopulmonary function, and health-related quality of life (HRQOL) after lung cancer surgery.
Article Synopsis
- There is limited knowledge on how emphysema and small airway disease impact the progression of COPD, even when analyzing data from two separate patient groups.
- Using chest CT scans, researchers divided COPD patients with low levels of emphysema (less than 10%) into two groups (low and high PRM) and looked for changes in emphysema over time.
- Results showed that patients with high PRM experienced more significant increases in emphysema compared to those with low PRM, suggesting that small airway disease might occur before emphysema in early COPD patients.
Characteristics of chronic obstructive pulmonary disease (COPD) patients with superoptimal peak inspiratory flow rates (PIFR) has not been thoroughly investigated. This study aimed to compare the characteristics between COPD patients with superoptimal PIFR and those with optimal and sub-optimal PIFR. PIFR was measured using In-Check DIAL G16 and categorized into sub-optimal (PIFR lower than that required by the patient's device), optimal, and superoptimal (peak PIFR ≥ 90 L/min).
View Article and Find Full Text PDFBackground And Objectives: The recent developments in chronic thromboembolic pulmonary hypertension (CTEPH) are emphasizing the multidisciplinary team. We report on the changes in clinical practice following the development of a multidisciplinary team, based on our 7 years of experience.
Methods: Multidisciplinary team was established in 2015 offering both balloon pulmonary angioplasty (BPA) and pulmonary endarterectomy (PEA) with technical upgrades by internal and external expertise.
Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment of acute bronchitis: multicenter, randomized, double-blinded, active-controlled, parallel, therapeutic confirmatory clinical trial.
Curr Med Res Opin
July 2024
Background: Acute bronchitis is the most common respiratory disease. Mixture of Ivy Leaf Extract and Coptidis rhizome syrup has shown good treatment efficacy against chronic bronchitis and acute respiratory infections. This study aimed to evaluate the efficacy and safety of Mixture of Ivy Leaf Extract and Coptidis rhizome compared with those of extract, for the treatment of acute bronchitis.
View Article and Find Full Text PDFBackground: Accelerated lung function decline is characteristic of COPD. However, the association between blood eosinophil counts and lung function decline, accounting for current smoking status, in young individuals without prevalent lung disease is not fully understood.
Methods: This is a cohort study of 629 784 Korean adults without COPD or a history of asthma at baseline who participated in health screening examinations including spirometry and differential white blood cell counts.
Article Synopsis
- - This study looks at how changes in body mass index (BMI) affect health outcomes in over 116,000 patients diagnosed with chronic obstructive pulmonary disease (COPD) between 2014 and 2019.
- - It found that significant BMI loss (>5%) was linked to a higher risk of all-cause mortality (1.70 times more likely) compared to those who maintained their BMI, while a small increase (>5%) in BMI also posed some risk (1.13 times more likely).
- - Overall, weight loss was particularly detrimental for underweight COPD patients, indicating that tracking BMI changes could be crucial for managing their health effectively.
Article Synopsis
- Chronic thromboembolic pulmonary disease (CTEPD) can restrict exercise even when patients show normal right ventricular (RV) function or no pulmonary hypertension at rest, making the combination of exercise stress echocardiography and cardiopulmonary exercise testing (ESE-CPET) valuable for evaluation.
- In a study involving 50 CTEPD patients with mild disease, results showed decreased maximal oxygen consumption (peak VO) and a significant increase in RV systolic pressure (RVSP) during exercise, indicating altered heart responses to physical activity.
- The findings suggest that patients with mild pulmonary hypertension or no hypertension still experience exercise limitations, with RV dysfunction becoming evident during exercise, particularly in those with impaired exercise capacity.
Background: The effects of smoking reduction on the incidence of lung cancer in patients with chronic obstructive pulmonary disease (COPD) are not well known. This study aimed to investigate the effects of changes in smoking habits after COPD diagnosis on lung cancer development in patients who smoked less than 30 pack-years.
Methods: This nationwide retrospective cohort study included 16,832 patients with COPD who smoked less than 30 pack-years at the time of COPD diagnosis.
Article Synopsis
- Aerobic moderate-to-vigorous physical activity (MVPA), combined with resistance training (RT), may positively impact sleep and reduce respiratory symptoms in men with chronic obstructive pulmonary disease (COPD).
- A study analyzed data from over 61,000 individuals, focusing on 794 men with airflow limitations who engaged in MVPA, finding that those who also did RT reported fewer sleep problems, chronic cough, and sputum production.
- The benefits of adding RT to MVPA were more significant in men with a forced expiratory volume (FEV) of less than 80% of the predicted value, indicating a stronger effect on health for those with greater airflow limitations.
Article Synopsis
- * Out of 810 patients, 19.6% experienced PPCs, with those in the low lung function groups having a significantly higher relative risk (RR) for developing these complications compared to those with better lung function.
- * The findings suggest that poor preoperative lung function increases the risk of PPCs after esophagectomy, especially when both FEV and DLco levels are low.
Article Synopsis
- The study investigates the effectiveness of hypofractionated proton beam therapy (PBT) for early-stage lung cancer in patients who cannot undergo surgery, analyzing data from 27 patients diagnosed with inoperable non-small cell lung cancer (NSCLC).
- Results showed a 73.5% local control rate after two years, with better outcomes for smaller tumors, while about 48% of the patients experienced disease progression.
- The treatment was generally safe with minimal severe side effects, but quality of life issues like increased breathlessness were noted post-treatment, indicating room for improvement in managing symptoms.
Background: Fractional exhaled nitric oxide (FeNO) is known to useful biomarker for detecting eosinophilic airway inflammation. However, there is a lack of evidence regarding the role of FeNO in chronic obstructive pulmonary disease (COPD). We aimed to assess whether elevated FeNO and its impact on treatment change into an inhaled corticosteroid (ICS)-containing regimen and association with acute exacerbation (AE) in patients with COPD.
View Article and Find Full Text PDFBackground: Patients with chronic obstructive pulmonary disease (COPD) have a high risk of developing lung cancer. Due to the high rates of complications from invasive diagnostic procedures in this population, detecting circulating tumor DNA (ctDNA) as a non-invasive method might be useful. However, clinical characteristics that are predictive of ctDNA mutation detection remain incompletely understood.
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- Preserved ratio impaired spirometry (PRISm) is linked to higher risk of cardiovascular disease (CVD) and mortality, but its direct causal relationship with CVD isn't fully established.
- A study examined 11,420 participants aged 40 and older, assessing their coronary artery calcium (CAC) scores based on the presence of PRISm and reduced forced vital capacity (FVC).
- Results showed that participants with PRISm experienced a significant increase in CAC progression over five years, especially pronounced in those with low FVC.
Purpose: Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by chronic inflammation. Acute exacerbation of COPD (AECOPD) manifests as acute worsening of respiratory symptoms and is associated with high morbidity and mortality. The aim of the present study was to evaluate the predictive value of white blood count (WBC) and its derived inflammatory biomarkers for AECOPD.
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- * Data from 419 patients revealed that 24.1% and 17.7% experienced CPF recovery failure at 6 months and 1 year after surgery, with significant predictors including lower baseline physical activity, higher dyspnoea, and reduced lung function.
- * The findings suggest that maintaining physical activity before and shortly after surgery is crucial for improving CPF recovery in these patients, highlighting the need for proactive perioperative activity engagement.
Background: Moderate to vigorous physical activity (MVPA) in patients with COPD affects their overall health outcomes, including symptom relief and improved quality of life. However, the magnitude of the effect of MVPA initiation on real-world clinical outcomes has not been well investigated.
Research Question: How does MVPA initiation affect mortality and severe exacerbation in patients who have not engaged in MVPA prior to COPD diagnosis?
Study Design And Methods: This study included patients with COPD aged ≥ 40 years who were not performing MVPA prior to COPD diagnosis and who had at least one health screening visit prior to and following their COPD diagnosis between January 1, 2010, and December 31, 2018.
Background: Evidence on whether long-term exposure to air pollution increases the mortality risk in patients with chronic obstructive pulmonary disease (COPD) is limited.
Objectives: We aimed to investigate the associations of long-term exposure to particulate matter with diameter <10 µm (PM) and nitrogen dioxide (NO) with overall and disease-specific mortality in COPD patients.
Design: We conducted a nationwide retrospective cohort study of 121,423 adults ⩾40 years diagnosed with COPD during 1 January to 31 December 2009.