Publications by authors named "Hye Ryun Yu"
KSHV vIRF4 enhances BCL6 transcription via downregulation of IRF4 expression.
Biochem Biophys Res Commun
February 2018
Article Synopsis
- Primary effusion lymphoma (PEL) is linked to KSHV infection and shows constant expression of IRF4 while suppressing BCL6.
- Recent findings indicate that IRF4 may regulate KSHV's latency and reactivation in PEL cells.
- The study reveals that KSHV's vIRF4 enhances BCL6 activity by inhibiting IRF4, showing a critical relationship between these factors during KSHV's life cycle, particularly during lytic replication.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms. The endothelium is the thin layer of squamous cells where vascular blood endothelial cells (BECs) line the interior surface of blood vessels and lymphatic endothelial cells (LECs) are in direct contact with lymphatic vessels. The KS lesions contain a prominent compartment of neoplastic spindle morphology cells that are closely related to LECs.
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