Publications by authors named "Hye Rin Moon"
Article Synopsis
- A study examined how genetic and epigenetic factors related to arachidonic acid metabolism and clopidogrel activation affect resistance to aspirin and clopidogrel, looking to improve predictions of ischemic stroke recurrence alongside traditional cardiovascular risk factors.
- Researchers enrolled 988 patients with past ischemic attacks and measured their responses to aspirin and clopidogrel over 12 weeks using specific reaction units to assess any clinical resistance.
- The findings revealed that integrating certain genetic markers and promoter methylation into existing risk models significantly improved prediction accuracy for stroke recurrence (from 3.4% to 13.8%) and helped to better predict reaction levels to the medications.
Background: Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be used as an epigenetic tool to evaluate the impact of aging and the environment on atherosclerosis development.
View Article and Find Full Text PDFThe stromal vascular fraction (SVF) in adipose tissue contains a pool of various stem and progenitor cells, but the existence of hematopoietic stem and progenitor cells (HSPCs) in the SVF has not been seriously considered. We detected the presence of HSPCs in the SVF by phenotypically probing with Lin(-)Sca-1(+)c-kit(+) (LSK) and functionally confirming the presence using colony-forming cell assay and assessing the long-term multilineage reconstitution ability after SVF transplantation. The LSK population in the SVF was 0.
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