Publications by authors named "Hye K Park"
Purpose: To determine effects of colonization with multidrug-resistant bacteria (MDRB) in general wards on characteristics, treatment, and prognosis of hospital-acquired pneumonia (HAP).
Methods: This was a multicenter retrospective cohort study of patients with HAP admitted to 16 tertiary or university hospitals in Korea from July 2019 to December 2019. From the entire cohort, patients who developed pneumonia in general wards with known colonization status before the onset of pneumonia were included in this study.
Background: Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort.
View Article and Find Full Text PDFIntroduction: Concurrent obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are referred to as COPD-OSA overlap. We investigated the prevalence and clinical significance of COPD-OSA overlap in the general population of South Korea.
Methods: Data were obtained from the 2019 Korea National Health and Nutrition Examination Survey.
Article Synopsis
- The study, conducted by the Center for Personalized Precision Medicine of Tuberculosis (cPMTb), aims to create personalized treatment systems for tuberculosis (TB) and to compare patients with TB, non-tuberculosis mycobacterial infection (NTM), and latent TB infection (LTBI).
- A total of 1,226 patients were analyzed, revealing that TB patients were generally older, had lower body mass index (BMI), and higher diabetes rates compared to those with LTBI, while patients with NTM had a higher female proportion and a history of TB.
- The analysis of genetic traits showed similar distributions of N-acetyltransferase-2 (NAT2) and SLCO
Background: Despite a well-known relation between smoking tobacco and the tuberculosis epidemic, the factors associated with smoking cessation in tuberculosis patients are unclear. This study aims to examine the cascade of smoking cessation and the factors associated with persistent smoking among tuberculosis patients.
Methods: We conducted a prospective cohort study enrolling adult patients with pulmonary tuberculosis between 2016 and 2019 in the Republic of Korea.
Article Synopsis
- The study aimed to assess whether using a combination of fluoroquinolone antibiotics reduces mortality in patients with hospital-acquired pneumonia (HAP) compared to β-lactam monotherapy.
- It involved a retrospective analysis of 631 patients across 16 hospitals in Korea during 2019, with a focus on 30-day mortality rates.
- Results indicated no significant difference in mortality between the combination therapy and monotherapy groups, suggesting that fluoroquinolone combinations may not provide additional survival benefits for HAP patients.
Background: Although the Life-Sustaining Treatment (LST) Decision Act was enforced in 2018 in Korea, data on whether it is well established in actual clinical settings are limited. Hospital-acquired pneumonia (HAP) is a common nosocomial infection with high mortality. However, there are limited data on the end-of-life (EOL) decision of patients with HAP.
View Article and Find Full Text PDFBackground: Sterility and safety assurance of hematopoietic stem cell (HSC) products is critical in transplantation. Microbial contamination can lead to product disposal and increases the risk of unsuccessful clinical outcomes. Therefore, it is important to implement and maintain good practice guidelines and regulations for the HSC collection and processing unit in each hospital.
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- The study aimed to create machine-learning models that use CT scans and clinical data to predict respiratory outcomes in COVID-19 patients, focusing on pneumonia, hypoxia, and respiratory failure.
- A total of 387 patients were analyzed, revealing that 50.4% developed pneumonia, while 22% experienced hypoxia and 4.9% faced respiratory failure; several clinical factors, including vaccination status and laboratory results, were identified as significant predictors.
- The models demonstrated high predictive accuracy, with area under the receiver operating characteristic curve (AUC) values of 0.904 for pneumonia, 0.890 for hypoxia, and 0.969 for respiratory failure, indicating their reliability in clinical settings.
Background/objective: Metabolic syndrome (MS) is related to lung dysfunction. However, its impact according to insulin resistance (IR) remains unknown. Therefore, we evaluated whether the relation of MS with lung dysfunction differs by IR.
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- The study categorizes chronic cough into four distinct phenotypes based on age, severity, and gender characteristics.
- Participants were evaluated using the COugh Assessment Test (COAT) and a correlation network was created to identify relevant variables for cluster analysis.
- The identified clusters suggest a need for personalized medical strategies, as each phenotype shows significant differences in underlying causes and symptoms.
Diffuse alveolar haemorrhage (DAH) is a life-threatening condition caused by widespread damage to the small pulmonary vessels. Common chest imaging findings in patients with DAH show bilateral diffuse airspace opacities. DAH complicating antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, including microscopic polyangiitis, should be considered as a differential diagnosis in patients with progressive dyspnea, reduced haemoglobin levels, and alveolar opacities on chest imaging.
View Article and Find Full Text PDFRegdanvimab is the only monoclonal antibody available in Korea that targets severe acute respiratory syndrome coronavirus 2. We retrospectively evaluated the clinical characteristics of 374 adults hospitalized with coronavirus disease 2019 (COVID-19) who were treated with regdanvimab from September through December 2021. In total, 322 (86.
View Article and Find Full Text PDFFrailty is an important risk factor for adverse health-related outcomes. It is classified into several phenotypes according to nutritional state and physical activity. In this context, we investigated whether frailty phenotypes were related to clinical outcome of hospital-acquired pneumonia (HAP).
View Article and Find Full Text PDFBackground/aims: Most studies on hospital-acquired pneumonia (HAP) have been conducted in intensive care unit (ICU) settings. This study aimed to investigate the microbiological and clinical characteristics of non-ICU-acquired pneumonia (NIAP) and to identify the factors affecting clinical outcomes in Korea.
Methods: This multicenter retrospective cohort study was conducted in patients admitted to 13 tertiary hospitals between July 1, 2019 and December 31, 2019.
Background: Chest computed tomography (CT) scans play an important role in the diagnosis of coronavirus disease 2019 (COVID-19). This study aimed to describe the quantitative CT parameters in COVID-19 patients according to disease severity and build decision trees for predicting respiratory outcomes using the quantitative CT parameters.
Methods: Patients hospitalized for COVID-19 were classified based on the level of disease severity: (1) no pneumonia or hypoxia, (2) pneumonia without hypoxia, (3) hypoxia without respiratory failure, and (4) respiratory failure.
Impact of prior vaccination on clinical outcomes of patients with COVID-19.
Emerg Microbes Infect
December 2022
Article Synopsis
- * Compared to unvaccinated patients, those who were vaccinated had a lower incidence of pneumonia (36.8% vs. 65.6%) and needed less supplemental oxygen (15.7% vs. 29.0%), and discharged from the hospital sooner (10 days vs. 11 days).
- * Vaccination significantly reduced the likelihood of pneumonia and the need for oxygen by approximately 70% and 82%, respectively, highlighting the importance of ongoing vaccination efforts to mitigate severe COVID-19 outcomes.
Article Synopsis
- The study investigates the effects of metabolically-healthy obesity (MHO) on lung function, contrasting it with different body weight and metabolic health statuses among a large cohort of over 114,000 individuals.
- Results show that while MHO individuals had better overall lung function measures (like FEV1% and FVC%) compared to metabolically unhealthy groups, they still exhibited a lower FEV1/FVC ratio, indicating potential issues with airflow.
- The study concludes that although MHO appears to have superior lung function compared to metabolically unhealthy groups, further research is necessary to confirm these results over time.
Vaccination is an important strategy for controlling the coronavirus disease 2019 (COVID-19) pandemic. We conducted a web-based cross-sectional survey based on Google Forms to collect data on adverse events (AEs) after the first dose of the ChAdOx1 nCoV-19 vaccine for healthcare workers (HCWs). Among the 1,676 vaccinated HCWs, 59.
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- A study analyzed clinical data from 7,803 COVID-19 patients in South Korea, focusing on early symptoms, disease progression, and severity after quarantine release.
- Results showed that 94.5% of patients were asymptomatic or mildly ill at admission, but severe cases had high fatality rates, with older age, male gender, and certain symptoms like fever and shortness of breath increasing the likelihood of critical illness.
- The findings suggest that while most patients recovered or were asymptomatic, those with comorbidities faced greater risks of critical illness and death.
Article Synopsis
- * A study involving 454 tuberculosis patients in Korea aimed to determine optimal INH doses tailored to each acetylator phenotype, highlighting the impact of NAT2 on drug clearance.
- * The findings suggest that effective dosing regimens for Korean patients should be 400 mg for rapid, 300 mg for intermediate, and 200 mg for slow acetylators taken once daily, advancing tailored treatment strategies for tuberculosis.
Severe Cutaneous Adverse Reactions to Anti-tuberculosis Drugs in Korean Patients.
Allergy Asthma Immunol Res
March 2021
Purpose: Anti-tuberculosis drugs (ATDs) can cause severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Underlying tuberculous infection and co-administration of multiple drugs may contribute to the complexity of ATD-related SCARs. This study aimed to investigate the clinical characteristics and outcomes of ATD-related SCARs.
View Article and Find Full Text PDFBackground: Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases.
Methods: In this prospective cohort study, we enrolled adult patients aged ≥ 19 years with pulmonary TB between 2016 and 2018.