Publications by authors named "Hye In Kim"

Previous studies suggested a link between ( infection and steatotic liver disease, now termed metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to identify the association of active infection and the new concept of MASLD in a longitudinal cohort. We reviewed 1497 health examinees who had two endoscopic biopsies for activity without hepatic steatosis at the baseline abdominal ultrasonography.

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Background: We aimed to investigate the prognostic significance of primary tumor size in patients with pT1-T3a N0 M0 papillary thyroid carcinoma (PTC), minimizing the impact of confounding factors.

Methods: A multicenter retrospective study included 5,759 patients with PTC. Those with lymph node metastasis, gross extrathyroidal extension (ETE), and aggressive variants were excluded.

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Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a hepatic manifestation of metabolic syndrome. This study investigated the association between newly developed nomenclature MASLD and the risk of thyroid cancer in the Korean population. After excluding individuals with a history of liver disease or malignancy, we analyzed a cohort of 214,502 Korean adults aged 40 years and above who participated in the National Health Screening Program from 2009 to 2010.

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Article Synopsis
  • - The study investigated the connection between total triiodothyronine (TT3) levels and the development and resolution of steatotic liver disease (SLD) over time in a cohort of 1,665 euthyroid South Korean adults who had multiple thyroid function tests.
  • - Results showed that during a median follow-up of 5 years, higher TT3 levels were linked to a greater risk of developing SLD and a lower chance of resolution compared to those with lower TT3 levels.
  • - The findings suggest that TT3 levels play a significant role in both the onset and improvement of SLD and modified metabolic dysfunction-associated steatotic liver disease (MASLD) in the studied population.
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Nerve agents are toxic organophosphorus chemicals and acetylcholinesterase inhibitors that have been used in terrorist acts. Because they exhibit fatal toxic effects in small amounts, technology is required to detect and identify them early. Research for nerve agent detection using structural simulants of real agents may not function properly for real agents depending on the selectivity of the sensor.

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  • - The study investigates the role of thyroid immune-related adverse events (irAEs) in predicting the effectiveness of PD-1 blockade for treating non-small cell lung cancer (NSCLC), revealing they are independent of PD-L1 expression.
  • - Out of 71 metastatic NSCLC patients analyzed, those with thyroid irAE showed significantly longer progression-free survival compared to those without, indicating that thyroid irAEs can serve as a useful biomarker in treatment outcomes.
  • - Alternative staging methods that incorporate thyroid irAEs improved the prognostic accuracy for disease progression compared to standard TNM staging, emphasizing the importance of these irAEs in identifying patients likely to respond well to PD-1 blockade therapies.
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  • * Current tobacco users showed a significantly higher risk of poor HRQoL compared to those who have never smoked, particularly in areas like mobility and pain/discomfort.
  • * The findings suggest that both combustible cigarettes and non-combustible nicotine products negatively impact HRQoL, highlighting the need for improved smoking cessation strategies and lifestyle changes to support users.
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Background: The liver plays an important role in gonadal steroid hormone metabolism, which can affect reproductive health, including the menstrual cycle. However, evidence from large population-based studies is limited. Therefore, this study aimed to investigate the association between liver function markers and menstrual cycle irregularities in premenopausal Korean women using nationwide data.

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Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear. Here we examined the effects of HLA genetic variation on the expression of 2940 plasma proteins across 45,330 Europeans in the UK Biobank, with replication analyses across multiple ancestry groups. We detected 504 proteins affected by HLA variants (HLA-pQTL), including widespread trans effects by autoimmune disease risk alleles.

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  • - The study compared uterine volume (UV) among Turner syndrome (TS) patients who underwent pubertal induction (PI), those who experienced natural menarche (NM), and a control group without TS to identify key factors in uterine development.
  • - Results indicated that the first UV was significantly larger in the NM group compared to the PI group, with the final UV of the PI group still being smaller than the NM group despite an increase over time.
  • - The findings suggest that while natural menarche leads to normal uterine development, those with TS who received pubertal induction may have smaller, less developed uteruses, possibly due to late initiation of hormone replacement therapy (HRT) and the type of estrogen used.
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  • Bulbar dysfunction in ALS negatively impacts daily life, causing issues like weight loss and shorter survival rates, with existing evaluation methods lacking Korean-specific tools.* -
  • This study developed and validated the Korean version of the Center for Neurologic Study Bulbar Function Scale (K-CNS-BFS) to assess bulbar dysfunction in Korean ALS patients.* -
  • The K-CNS-BFS demonstrated strong reliability and validity, effectively measuring bulbar dysfunction and correlating well with established ALS assessments.*
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Tobacco mild green mosaic virus (TMGMV)-like nanocarriers were designed for gene delivery to plant cells. High aspect ratio TMGMVs were coated with a polycationic biopolymer, poly(allylamine) hydrochloride (PAH), to generate highly charged nanomaterials (TMGMV-PAH; 56.20 ± 4.

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Dynamic optical modulation in response to stimuli provides exciting opportunities for designing novel sensing, actuating, and authentication devices. Here, we demonstrate that the reversible swelling and deswelling of crosslinked polymer colloidal spheres in response to pH and temperature changes can be utilized to drive the assembly and disassembly of the embedded gold nanoparticles (AuNPs), inducing their plasmonic coupling and decoupling and, correspondingly, color changes. The multi-responsive colloids are created by depositing a monolayer of AuNPs on the surface of resorcinol-formaldehyde (RF) nanospheres, then overcoating them with an additional RF layer, followed by a seeded growth process to enlarge the AuNPs and reduce their interparticle separation to induce significant plasmonic coupling.

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Introduction: We compared the effects of heat on the physicochemical properties of recently developed calcium silicate-based sealers (CSBSs), including BioRoot Flow, BioRoot RCS, and AH Plus Bioceramic sealer, with those of the epoxy-resin-based sealer (ERBS) AH Plus.

Methods: The flow, film thickness, setting time, and solubility of sealers were evaluated at 37 °C and 100 °C using ISO 6876/2012. Furthermore, pH and calcium ion release were evaluated at these temperatures.

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Background: Since the emergence of hypervirulent strains of , the incidence of infections (CDI) has increased significantly.

Methods: To assess the incidence of CDI in Korea, we conducted a prospective multicentre observational study from October 2020 to October 2021. Additionally, we calculated the incidence of CDI from mass data obtained from the Health Insurance Review and Assessment Service (HIRA) from 2008 to 2020.

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The sacred lotus ( Gaertn. Isolate Haman, in the family Nelumbonaceae) used in this study originated from the Haman region of Korea, and lotus seeds dating back to the Goryeo Dynasty (650-760 years ago) were accidentally discovered. Lotus is known to possess antioxidant, anti-inflammatory, and soothing properties.

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A lack of mechanistic understanding of nanomaterial interactions with plants and algae cell walls limits the advancement of nanotechnology-based tools for sustainable agriculture. We systematically investigated the influence of nanoparticle charge on the interactions with model cell wall surfaces built with cellulose or pectin and performed a comparative analysis with native cell walls of plants and green algae (). The high affinity of positively charged carbon dots (CDs) (46.

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Background: Age at diagnosis (AAD) and telomerase reverse transcriptase (TERT) promoter mutations are prognostic factors in differentiated thyroid carcinoma (DTC), and the prevalence of the mutations increases with AAD. Considering this correlation, we investigated whether an interaction between AAD and the mutations is present and whether the mutation mediates the effect of AAD on the mortality rate in DTC.

Methods: The study included 393 patients with DTC who were followed-up after thyroidectomy at a single medical center in Korea from 1994 to 2004.

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Objective: We aimed to determine whether ovarian-preserving surgery for adnexal torsion helps preserve ovarian function without increasing the risk of postoperative complications.

Methods: We retrospectively evaluated 71 women who were surgically diagnosed with adnexal torsion between January 2015 and December 2019 at Severance Hospital, Yonsei University College of Medicine (ovarian preservation group, 56; oophorectomy, 15). Serum anti-Müllerian hormone (AMH) levels measured within 6 months before surgery were compared to levels measured 6-24 months after surgery.

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Roselle ( L.) is a plant that has traditionally been used in various food and beverage products. Here, we investigated the potential of water extracts derived from Roselle leaves and callus cells for cosmetic and pharmaceutical purposes.

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Backgruound: Fatty liver is associated with increased risk of developing type 2 diabetes. We aimed to evaluate whether the severity of hepatic steatosis is associated with incident diabetes.

Methods: We conducted a longitudinal analysis using data from 1,798 participants who underwent a comprehensive health checkup and abdominal computed tomography (CT).

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Aims: Protease-activated receptor 2 (PAR2), a type of G protein-coupled receptor (GPCR), plays a significant role in pathophysiological conditions such as inflammation. A synthetic peptide SLIGRL-NH (SLIGRL) can activate PAR2, while FSLLRY-NH (FSLLRY) is an antagonist. A previous study showed that SLIGRL activates both PAR2 and mas-related G protein-coupled receptor C11 (MrgprC11), a different type of GPCR expressed in sensory neurons.

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Article Synopsis
  • The production of fruit waste and organic micropollutants poses significant environmental challenges, but fruit peels like those from oranges, mandarins, and bananas can be used as effective biosorbents to help remove these pollutants.
  • Evaluating the adsorption affinity of these biosorbents for various micropollutants is complicated and resource-intensive, leading researchers to develop quantitative structure-adsorption relationship (QSAR) models that simplify this process.
  • The study found that the fruit peels effectively adsorbed cationic and neutral micropollutants, while having less affinity for anionic ones, and the developed models showed high accuracy in predicting adsorption outcomes, suggesting they can be used for other micropollutants as well
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  • Genome-wide association studies have identified many common genetic variants tied to human diseases, but the exploration of rare genetic variations has been limited.
  • This study analyzes exome-sequencing data from 394,841 individuals in the UK Biobank to assess the impact of rare coding variations across 4,529 phenotypes, linking genetic associations to their frequency and potential harmfulness.
  • The findings contribute to our understanding of genetic factors in health and disease, offering a public dataset and tools like the Genebass browser for researchers to investigate rare variant associations.
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Background: Single nucleotide polymorphisms (SNPs) are reportedly associated with repeated abortion. Thus, genetic analysis based on race is the key to developing accurate diagnostic tests. This study analyzed the genetic polymorphisms of recurrent pregnancy loss (RPL) patients among Korean women compared to the controls.

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