Publications by authors named "Hye Ah Lee"
Objective: This study examined the mediating effect of negative changes in daily life due to the coronavirus disease-2019 (COVID-19) pandemic on depressive symptoms, considering COVID-19 infection and related social concerns. Additionally, comparisons of path coefficients between the groups were conducted based on age and gender.
Methods: A cross-sectional study design used data from the 2020 Korean Community Health Survey consisting of 229,269 individuals.
Article Synopsis
- This study explored the link between childhood handgrip strength and the risk of metabolic syndrome (MetS) and insulin resistance in adolescence.
- Participants' handgrip strength was measured from ages 7 to 9, and their metabolic health was assessed when they reached ages 13 to 15.
- The results showed that higher relative handgrip strength in childhood was associated with lower MetS scores and insulin resistance in adolescence, suggesting that boosting muscle strength early in life could help reduce health risks later on.
Background: We explored the changes in metabolic dysfunction-associated steatotic liver disease (MASLD) severity over time by analyzing data from the placebo arms of randomized controlled trials (RCTs), focusing on the presence of diabetes.
Methods: RCTs on MASLD that included a placebo arm were identified using a systematic search of the literature. Primary outcomes were changes in hepatic steatosis and fibrosis.
Backgruound: Cumulative evidence consistently shows that anthropometric and body composition measurements are strongly linked to the risk of incident diabetes, typically based on baseline measurements. This study aims to assess whether repeated measurements enhance the prediction of diabetes risk beyond baseline assessments alone.
Methods: We utilized data from a 16-year population-based follow-up cohort within the Korean Genome and Epidemiology Study, comprising 6,030 individuals aged 40 to 69 years at baseline.
The emergence of the omicron variant and its sub-lineages has necessitated vaccine updates for coronavirus disease 2019. In September 2023, the U.S.
View Article and Find Full Text PDFArticle Synopsis
- COVID-19 vaccines demonstrate effectiveness but can cause adverse events (AEs), highlighting the need for ongoing monitoring to ensure safety and public health management.
- A study analyzed data from over 42 million vaccinated individuals in South Korea from February 2021 to January 2023, focusing on the frequency and severity of AEs related to vaccine dosages.
- Findings revealed that headaches, muscle pain, and fever were common AEs, with women reporting them more often than men, and middle-aged individuals (50-64 years) showing the highest rates compared to other age groups and socio-economic statuses.
Article Synopsis
- This study compared double low-dose hepatic multiphase CT (DLDCT) with standard-dose CT (SDCT) in terms of image quality and detectability for patients with chronic liver disease.
- DLDCT showed a significant reduction in radiation exposure (36.6%) and iodine concentration (22.9%) while maintaining higher overall image quality scores and better lesion contrast-to-noise ratio compared to SDCT.
- The findings suggest that DLDCT using a deep-learning model can effectively assess hepatic lesions without compromising image quality or detectability.
Clinical characteristics of seizure recurrence and epilepsy development in patients with alcohol-related seizures.
Alcohol Clin Exp Res (Hoboken)
November 2024
Article Synopsis
- The study examines the relationship between alcohol withdrawal and seizure recurrence, as well as the development of epilepsy among patients with a history of chronic alcohol consumption.
- Out of 191 analyzed patients, over half experienced recurring seizures, and 41.4% developed epilepsy, with factors like alcohol levels, seizure type, and comorbidities playing key roles in these outcomes.
- The study's predictive models for seizure recurrence and epilepsy showed strong diagnostic accuracy, indicating that specific clinical factors can effectively forecast these risks.
Background & Aims: We compared the effects of a 12-week intermittent calorie restriction (ICR) and standard-of-care (SOC) diet on liver fat content (LFC) in metabolic dysfunction-associated steatotic liver disease patients.
Methods: This randomized controlled trial included patients with magnetic resonance imaging-proton density fat fraction ≥8%. Patients were randomly assigned to the ICR (5:2 diet) or SOC (80% of the recommended calorie intake) groups and stratified according to the body mass index (≥25 or <25 kg/m).
Article Synopsis
- Despite advancements in hepatitis C therapy, hepatocellular carcinoma (HCC) can still occur after patients achieve sustained viral response (SVR), prompting a study on the predictive capabilities of vibration-controlled transient elastography (VCTE) and fibrosis 4-index (FIB-4) for HCC development post-SVR.
- The meta-analysis included 27 studies with a total of 169,911 patients, assessing the tests' performance in predicting HCC using pooled estimates of sensitivity, specificity, and area under the curve (AUC).
- The results indicated that both VCTE and FIB-4 have good predictive capabilities for HCC development after SVR, with optimal cut-off values identified for risk assessment, highlighting
Background/aims: Gastroesophageal reflux disease (GERD) is typically managed based on the clinical phenotype. We evaluated the efficacy and safety of potassium-competitive acid blockers (PCABs) in patients with various clinical GERD phenotypes.
Methods: Core databases were searched for studies comparing PCABs and proton pump inhibitors (PPIs) in clinical GERD phenotypes of erosive reflux disease (ERD), non-erosive reflux disease (NERD), PPI-resistant GERD and night-time heartburn.
We aimed to investigate the potential impact of metabolic risk factors and lifestyles on mortality in hepatocellular carcinoma (HCC) patients. From the Korean Central Cancer Registry database (2008-2016), 8,505 HCC patients were included in the analysis. Patients with 2 or more metabolic risk factors (n = 2384, 28.
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- - The study highlights the importance of physical activity for overall health in adolescents and aims to gather data to inform public health policies in South Korea by developing a comprehensive survey.
- - A detailed questionnaire was created based on expert reviews and focus group discussions, confirming its validity and reliability among middle and high school students, with 15 main items focusing on various aspects of physical activity.
- - Results show a concerning trend: a small percentage of adolescents meet recommended activity levels, with significant barriers to participation in school sports clubs, indicating a need for improved strategies to encourage physical activity.
Objectives: This study aimed to validate the Korean version of the sleep hygiene practice scale (SHPS-K) and determine its effectiveness in screening poor sleepers with insomnia.
Methods: Online survey was conducted using translated SHPS in Korean, the Korean versions of the Pittsburgh Sleep Quality Index (PSQI-K), Insomnia Severity Index (ISI-K), and Epworth Sleepiness Scale (KESS) in a non-clinical population. The internal consistency and test-retest reliability of the SHPS-K were assessed using Cronbach's alpha and intraclass correlation coefficients (ICC), respectively.
Background: Alcohol consumption is a major risk factor for cancer, and when combined with smoking, the risk increases. Nevertheless, few studies have comprehensively evaluated the combined effects of alcohol consumption and smoking on the risk of various cancer types. Therefore, to assess these effects, we conducted a systematic review and meta-analysis.
View Article and Find Full Text PDFObjectives: Certain studies have reported that handgrip strength (HGS) is associated with metabolic health risks in children and adolescents, and some studies have suggested HGS thresholds for identifying poor metabolic health. Therefore, we aimed to determine the HGS thresholds associated with metabolic syndrome (MetS) in children and adolescents through a systematic review.
Methods: We searched 3 electronic databases from their inception until October 2023 to identify original papers that focused on children and adolescents and assessed their risks of MetS according to specific HGS values.
Article Synopsis
- - This study explored how thyroid function relates to insulin resistance (IR) in healthy adolescents, focusing on differences between boys and girls.
- - Researchers analyzed data from 465 adolescents using various tests to measure thyroid hormones and insulin resistance indicators.
- - Results showed that the connection between thyroid function and IR depended on the sex of the adolescents and was notably stronger in those who were overweight or obese.
Article Synopsis
- Postmenopausal women in a study were older on average than men, but had higher healthy cholesterol levels and lower smoking rates.
- Though men had a higher prevalence of significant coronary artery disease (b-CAD) and required more revascularization procedures, statistical analysis showed that sex did not significantly affect the likelihood of needing revascularization.
- Interestingly, the long-term cardiovascular outcomes were better for postmenopausal women compared to men, suggesting they respond well to optimal treatment despite being older at the start of the study.
Validation of the Framingham Diabetes Risk Model Using Community-Based KoGES Data.
J Korean Med Sci
February 2024
Article Synopsis
- An 8-year study evaluated the Framingham Diabetes Risk Model (FDRM) in the Korean population to address its outdated predictors compared to current clinical standards.
- Using data from 5,409 individuals, researchers developed a modified FDRM by redefining hypertension and diabetes predictors and adding relevant clinical features.
- The modified FDRM demonstrated improved prediction accuracy, with an AUC rising from 0.71 to 0.83, indicating effective risk stratification for diabetes, though further validation of the modified model is needed.
Article Synopsis
- - The study examined the links between genetic predisposition, the Lifestyle Inflammation Score (LIS), and the Food-based Dietary Inflammatory Index (FDII) regarding the incidence of diabetes among 6,568 participants aged 40-69 from a Korean study.
- - Results indicated a significant association between higher genetic risk scores (GRS) and LIS quartiles with increased diabetes incidence; for instance, those in the top LIS quartile had a 2.4-fold higher risk compared to the lowest quartile.
- - The study concluded that while GRS and LIS are independently linked to diabetes risk, their interaction did not show a significant effect, suggesting that improving lifestyle choices is crucial for diabetes prevention regardless of genetic factors.
Article Synopsis
- The SUPERBRAIN study from South Korea tested how lifestyle changes and nutritional supplements can help older people with early Alzheimer's disease.* -
- There were 46 participants split into three groups: one group got both lifestyle changes and supplements, another just got supplements, and the last group was a control group.* -
- After 8 weeks, the group with both changes and supplements did significantly better on memory tests and also showed improvements in their gut health compared to the other groups.*
Article Synopsis
- Childhood and adolescent obesity is getting worse, especially because of the COVID-19 pandemic, and it's affecting younger kids too.
- Early obesity can lead to serious health issues like diabetes and heart problems, so it's important to find these problems early in kids instead of waiting until they are adults.
- New ways to check for these health risks in children are being developed, but more research is needed to make sure they work well in detecting obesity-related health issues.
The detailed comorbidity patterns of community-dwelling older adults have not yet been explored. This study employed a network-based approach to investigate the comorbidity patterns of community-dwelling older adults living alone. The sample comprised a cross-sectional cohort of adults 65 or older living alone in a Korean city (n = 1041; mean age = 77.
View Article and Find Full Text PDFObjectives: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis.
View Article and Find Full Text PDFAim: To assess the effect of obesity phenotype on the incidence of diabetes, considering phenotype as a time-varying exposure.
Methods: We used community-based cohort data from the Korean Genome and Epidemiology Study, with a 16-year follow-up period. Obesity phenotype was determined using body mass index and metabolic syndrome criteria.