Acoustic deep brain modulation: Enhancing neuronal activation and neurogenesis.

Background: Non-invasive deep brain modulation (DBM) stands as a promising therapeutic avenue to treat brain diseases. Acoustic DBM represents an innovative and targeted approach to modulate the deep brain, employing techniques such as focused ultrasound and shock waves. Despite its potential, the optimal mechanistic parameters, the effect in the brain and behavioral outcomes of acoustic DBM remains poorly understood.

Assessing the efficacy of jet dispenser versus direct syringe injection for calcium hydroxide paste placement in artificial root canals.

This study aimed to evaluate the efficacy of a novel jet dispenser (JD) for filling simulated straight and curved canals with calcium hydroxide (Ca(OH)) paste by comparing the level of intracanal medicament with traditional direct syringe delivery. The Ca(OH) paste was delivered into the canals using either a direct syringe with binding tip and unbinding tip or a JD. The analysis of the ratio of the canal filled area (RCFA) in the coronal, middle, and apical thirds was conducted using the Kruskal-Wallis and Mann-Whitney U tests (α = 0.

A liquid breakdown driven non-invasive microjet injection system.

The purpose of this study was to develop a microjet having fully skin-penetrable jet speed, moderately small volume, and highly repeatable injection, and eventually providing a device with medical efficacy for less tissue destruction and pain. The injector allows a small volume of drug stream (0.1-1.