Publications by authors named "Hwayoung Yim"
Article Synopsis
- Delivering medicine to the brain is hard because of a protective barrier called the blood-brain barrier (BBB).
- Scientists are trying different methods to help drugs get through this barrier, like using certain receptors on cells to help transport them.
- Exosomes, which are tiny bubbles made by cells, are being studied because they can naturally cross the BBB and may help treat brain diseases more effectively.
Among extracellular vesicles, exosomes have gained great attention for their role as therapeutic vehicles for delivering various active pharmaceutical ingredients (APIs). Exosomes "armed" with anti-cancer therapeutics possess great potential for an efficient intracellular delivery of anti-cancer APIs and enhanced targetability to tumor cells. Various technologies are being developed to efficiently incorporate anti-cancer APIs such as genetic materials (miRNA, siRNA, mRNA), chemotherapeutics, and proteins into exosomes and to induce targeted delivery to tumor burden by exosomal surface modification.
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