Geliboluols A-D: Kaurane-Type Diterpenoids from the Marine-Derived Rare Actinomycete .

Four new kaurane-type diterpenoids, geliboluols A-D (-), along with one known analog (), were isolated from the culture broth of the marine-derived rare actinomycete . The structures of compounds - were determined by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR), the MPA method, and by comparing their optical rotation values with those in the literature. The new compounds were evaluated for their cytotoxicity against seven blood cancer cell lines by a CellTiter-Glo (CTG) assay and six solid cancer cell lines by a sulforhodamine B (SRB) assay.

Labdane-Type Diterpenoids from and Their Antimicrobial and Cytotoxic Activities.

Chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, , resulted in the discovery of five new labdane-type diterpenoids: chlorolabdans A-C (-), epoxylabdans A and B ( and ), along with one known analog (). The structures of the new compounds were determined by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR) and by comparing their experimental data with those in the literature. The new compounds were evaluated for their antimicrobial activity, and displayed significant activity against Gram-positive bacteria, with minimum inhibitory concentration (MIC) values ranging from 4 to 8 µg/mL.

Meirols A-C: Bioactive Catecholic Compounds from the Marine-Derived Fungus sp. 1210CH-42.

Three new catecholic compounds, named meirols A-C (-), and one known analog, argovin (), were isolated from the marine-derived fungus sp. 1210CH-42. Their structures were determined by extensive analysis of 1D, 2D NMR, and HR-ESIMS spectroscopic data.

Machine learning analysis for the association between breast feeding and metabolic syndrome in women.

This cross-sectional study aimed to develop and validate population-based machine learning models for examining the association between breastfeeding and metabolic syndrome in women. The artificial neural network, the decision tree, logistic regression, the Naïve Bayes, the random forest and the support vector machine were developed and validated to predict metabolic syndrome in women. Data came from 30,204 women, who aged 20 years or more and participated in the Korean National Health and Nutrition Examination Surveys 2010-2019.

Streptinone, a New Indanone Derivative from a Marine-Derived Inhibits Particulate Matter-Induced Inflammation.

Inflammatory diseases caused by air pollution, especially from particulate matter (PM) exposure, have increased daily. Accordingly, attention to treatment or prevention for these inflammatory diseases has grown. Natural products have been recognized as promising sources of cures and prevention for not only inflammatory but also diverse illnesses.

Rifamycin-Related Polyketides from a Marine-Derived Bacterium and Their Cytotoxic Activity.

Eight rifamycin-related polyketides were isolated from the culture broth of a marine-derived bacterium , including five known (- and ) and three new derivatives (, , and ). The structures of the new compounds were determined by means of spectroscopic methods (HRESIMS and 1D, 2D NMR) and a comparison of their experimental data with those previously reported in the literature. The isolated compounds were evaluated for their cytotoxicity against one normal, six solid, and seven blood cancer cell lines and showed moderate activity against all the tested cell lines with GI values ranging from 2.

Sesquiterpenes from and Their Cytotoxic Activity.

Nine sesquiterpenes, including eight pentalenenes (-) and one bolinane derivative (), were isolated from the culture broth of a marine-derived actinobacterium 213DD-006. Among them, , , , and were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations.

Thiolactones and Δ-Pregnene Steroids from the Marine-Derived Fungus sp. 1210CH-42 and Their -Glucosidase Inhibitory Activity.

The fungal genus was first reported in 2003 and has mostly been found on land. This is the first report of second metabolites from the marine-derived yeast-like fungus sp. One new thiolactone (), along with one revised thiolactone (), two new Δ-steroids (, ), and one known Δ-steroid (), were isolated from the sp.

Association between Consumption of Dietary Supplements and Chronic Kidney Disease Prevalence: Results of the Korean Nationwide Population-Based Survey.

Despite the enormous global market of dietary supplements, the impact of dietary supplements on kidney disease is still unclear. Based on the National Health and Nutrition Examination Survey from 2015 to 2017, this study evaluated the association between dietary supplement and chronic kidney disease (CKD) in 13,271 Korean adults. Among the dietary supplements, vitamin and mineral intake was the highest at 61.

TcPO2 Value Can Predict Wound Healing Time in Clinical Practice of CLTI Patients.

Background: Transcutaneous oxygen pressure (TcPO2) is a noninvasive, nonradiological test to measure local oxygen released from capillaries through the skin. Since it reflects the metabolic state of the lower limb, it can predict wound healing in patients with critical limb threatening ischemia (CLTI). The purpose of this study was to determine the effectiveness of TcPO2 test in evaluating wound healing potential of patients with CLTI.

New Angucycline Glycosides from a Marine-Derived Bacterium .

Chemical investigation of the ethyl acetate extract from the culture broth of the marine-derived actinobacterium 156VN-095 led to the isolation of three hitherto undescribed angucycline glycosides, including urdamycins W and X ( and ) and grincamycin U (), as well as their seven known congeners. The structures of the new compounds were elucidated by means of spectroscopic methods (HRESIMS, 1D and 2 D NMR) and comparison of their experimental data with literature values. Compounds - and were evaluated for their anti-Gram-positive bacterial effect and cytotoxicity against six cancer cell lines.

Aspersterols A-D, Ergostane-Type Sterols with an Unusual Unsaturated Side Chain from the Deep-Sea-Derived Fungus .

Four previously undescribed ergostane-type sterols, aspersterols A-D (-), were isolated from a deep-sea-derived fungus, IV17-109. The structures of the new compounds were determined by extensive analyses of their spectroscopic data, pyridine-induced deshielding effect, Mosher's method, and electronic circular dichroism calculations. The key feature of these sterols is the presence of a rare unsaturated side chain with conjugated double bonds at Δ and Δ.

New Glycosylated Secondary Metabolites from Marine-Derived Bacteria.

Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (), and two new trehalose lipids ( and ), together with three known compounds (-) were isolated from two marine-derived bacterial strains, 168CLC-66.1 and IV19-045. The structures of - were determined by extensive analysis and comparison of their spectroscopic data with literature values.

Isolation, Structure Determination, and Semisynthesis of Diphenazine Compounds from a Deep-Sea-Derived Strain of the Fungus and Their Biological Activities.

Phenazostatins E-J (-), six new diphenazine derivatives, were isolated from the EtOAc extract of the culture broth of a strain of derived from deep-sea sediments of the Indian Ocean Ridge. The structures of - were elucidated based on the HRESIMS and 1D and 2D NMR spectra. The absolute configurations of -, except for and , were determined by modified Mosher's method, ECD data analysis, and calculations of optical rotation values.

Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of .

A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (), aspersidone B (), and agonodepside C (), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds (, , and ) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.

Anti-Mycoplasma Activity of Bacilotetrins C-E, Cyclic Lipodepsipeptides from the Marine-Derived and Structure Revision of Bacilotetrins A and B.

most commonly causes polyserositis and arthritis in swine and is a common contaminant during the cell culture in the laboratory. In our continuing research for diverse bioactive compounds from 109GGC020, we discovered uncommon cyclic lipotetrapeptides showing inhibitory activities against with similar structures to previously reported bacilotetrins A and B. Bacilotetrins C-E (-), new cyclic lipodepsipeptides, were isolated from the EtOAc extract obtained from the fermentation of marine-derived isolated from a marine sponge sample collected from the Gageo reef, Republic of Korea.

Polyketides and Meroterpenes from the Marine-Derived Fungi 158SC-067 and 01NT-1.1.5 and Their Cytotoxic and Antioxidant Activities.

Ten secondary metabolites, including a new grifolin analog, grifolin B (); a new homovalencic acid derivative, 12-hydroxyhomovalencic acid (); and a compound isolated from a natural source for the first time (), along with seven known compounds, grifolin (), averantin (), 7-chloroaverantin (), 1'--methylaverantin (), 7-hydroxy-2-(2-hydroxypropyl)-5-pentylchromone (), homovalencic acid (), and bekeleylactone E (), were isolated from two fungal strains. The structures of - were identified by detailed analysis and comparison of their spectroscopic data with literature values. Compounds and showed moderate cytotoxic activity against a panel of cancer cell lines (PC-3, HCT-15, MDA-MB-231, ACHN, NCI-H23, NUGC-3), with the GI values ranging from 1.

Reisolation and Structure Revision of Asperspiropene A.

Asperspiropene A was originally reported to have a unique 1,8-dioxaspiro[4.5]decane skeleton. During the course of our ongoing research for novel marine natural products, we isolated compound , which has identical 1D and 2D NMR data to asperspiropene A.

New Polyenes from the Marine-Derived Fungus with Anti-Neuroinflammatory and Cytotoxic Activities.

Three new polyene compounds, talacyanols A-C (-), along with two known compounds, ramulosin () and eurothiocin A (), were isolated from the marine fungus derived from a seaweed sp. Structures of - were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher's methods, as well as comparison with previously reported literature data. All the compounds (-) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities.

Anti-Neuroinflammatory Agent, Restricticin B, from the Marine-Derived Fungus and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells.

A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (), together with four known compounds (-) were obtained from the EtOAc extract of the marine-derived fungus . The planar structure of was determined by detailed analyses of MS, 1D and 2D NMR data. The relative and absolute configurations of were established via the analyses of NOESY spectroscopy data, the comparison of optical rotation values with those of reported restricticin derivatives and electronic circular dichroism (ECD).

Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus .

Two new glycosylated alkylresorcinols, resorcinosides A () and B (), were isolated from a strain of the fungus derived from a marine sediment sample collected from Cu Lao Cham Island, Vietnam. The structures of and were established by interpretation of 1D and 2D NMR and high-resolution ESIMS data, and their absolute configurations were confirmed by the coupling constant of the anomeric proton, acid hydrolysis, subsequent HPLC analysis, Mosher's method, and quantum-mechanics-based computational analysis of NMR chemical shifts. The structure elucidation indicated that and are new alkylresorcinols with d-glucose, and has an α-pyrone moiety attached to the aromatic ring.