Reactive oxygen species, electrode potential and pH affect CoCrMo alloy corrosion and semiconducting behavior in simulated inflammatory environments.

Crevice corrosion in modular taper junctions of hip or knee replacements using cobalt-chrome-molybdenum (CoCrMo) alloys remains a clinical concern. Non-mechanically-driven corrosion has been less explored compared to mechanically assisted crevice corrosion. This study hypothesized that solution chemistry within crevices, inflammation, and cathodic electrode potential shifts during fretting result in low pH and generate reactive oxygen species (ROS), affecting oxide film behavior.

Glutamate is a key nutrient for growth and survival during intracellular autophagic life under nutritionally limited conditions.

Unlabelled: survives in special autophagic vacuoles that serve as major replicative habitats in human primary gingival epithelial cells (GECs). As an asaccharolytic strict anaerobe, is dependent on amino acids and peptides for nutrient sources. However, it is largely unknown as to metabolic processing under the nutritionally limited intracellular environments such the vacuoles, especially the preferred amino acids and associated-metabolic machineries.