Publications by authors named "Hwang J"

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  • This study developed a robotic traction device aimed at improving endoscopic submucosal dissection (ESD) for colorectal procedures.
  • An experienced endoscopist conducted ESD on porcine colons, comparing the robot-assisted method to conventional techniques in 36 total procedures.
  • Results showed that the robot-assisted group had significantly shorter procedure times, faster dissection speeds, and lower blind dissection rates, indicating improved safety and efficiency.
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  • The advancements in long-read genome sequencing (lrGS) and the Telomere to Telomere (T2T) reference genome enhance the ability to detect structural variants like inversions, which are difficult to identify due to their properties and repetitive genetics.* -
  • In this study, researchers successfully analyzed genome data from six individuals with unidentified inversions, resolving two using traditional mapping and one requiring advanced techniques, leading to a diagnosis of Kleefstra syndrome.* -
  • The findings highlight the importance of using different reference genomes in detecting structural variations, particularly inversions, and suggest that employing graphic mapping techniques could significantly improve clinical genetic diagnostics.*
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Smart cities have emerged as a promising solution to the problems associated with urbanization. However, research that holistically considers diverse stakeholders in smart cities is scarce. This study utilizes data from four types of collaborators (academia, public sector, industry, and civil society actors) to identify key topics and suggest research areas for developing smart cities.

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  • B7-H3 (CD276) is a transmembrane glycoprotein associated with the immune checkpoint superfamily and is being researched as a potential therapeutic target in cancer treatment.
  • A study analyzed over 156,000 cancer samples to assess the correlation of B7-H3 mRNA expression with clinical outcomes, finding that high B7-H3 levels are linked to varying overall survival rates and are present in multiple cancer types, including prostate and lung cancers.
  • The research identified specific pathways related to high B7-H3 expression and the immunological environment of tumors, suggesting that the unique features of B7-H3 in different cancers may guide the development and application of targeted therapies.
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Hyperspectral imaging analysis combined with machine learning was applied to identify eight edible vegetable oils, and its classification performance was compared with the chemical method based on fatty acid compositions. Furthermore, the degree of adulteration in vegetable oils was quantitatively investigated using machine learning-enabled hyperspectral approaches. The hyperspectral absorbance spectra of palm oil with a high degree of saturation were distinctly different from those of the other liquid oils.

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We document the morphology, morphometric variations among the morphotypes of the brine shrimp, . From the samples collected at four different locations in South India, Tamil Nadu Kelambakkam, Vedaranyam, Tuticorin and Nagarcoil we identified six morphotypes: M1, M3, M4 in males and F1, F2, F3 in females. The Scanning electron micrographs of male morphotypes show distinct variation in the basal width, shape and number of cuticular cones on the second antennae.

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  • The study evaluated the effectiveness and tolerability of combining irbesartan (IRB) and amlodipine (AML) in treating essential hypertension when IRB alone was insufficient.
  • Two phase III clinical trials in Korea involved 428 patients and compared combinations of IRB/AML to placebo over 8 weeks, focusing on changes in mean sitting systolic blood pressure (MSSBP).
  • Results showed significant reductions in MSSBP in the combination groups compared to monotherapy, with adverse events occurring in a small percentage of participants, indicating the combined therapy was both effective and tolerable.
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This study aimed to evaluate and compare the mechanical properties of dental training teeth with subtractive and additive computer-aided design/computer-aided manufacturing (CAD/CAM) materials used to fabricate dental simulation models. Therefore, the three-axis load generated during cutting movements, including drilling and milling performed using a dental handpiece, was measured and compared. The samples were cut vertically downward by 1.

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Ultrafast photoinduced melting provides an essential platform for studying nonequilibrium phase transitions by linking the kinetics of electron dynamics to ionic motions. Knowledge of dynamic balance in their energetics is essential to understanding how the ionic reaction is influenced by femtosecond photoexcited electrons with notable time lag depending on reaction mechanisms. Here, by directly imaging fluctuating density distributions and evaluating the ionic pressure and Gibbs free energy from two-temperature molecular dynamics that verified experimental results, we uncovered that transient ionic pressure, triggered by photoexcited electrons, controls the overall melting kinetics.

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Viral pathogens, particularly influenza and SARS-CoV-2, pose a significant global health challenge. Given the immunomodulatory properties of human milk oligosaccharides, in particular 2'-fucosyllactose and 3-fucosyllactose (3-FL), we investigated their dietary supplementation effects on antiviral responses in mouse models. This study revealed distinct immune modulations induced by 3-FL.

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The emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has posed a significant global health concern due to its severe respiratory illness and high fatality rate. Currently, despite the potential for resurgence, there are no specific treatments for MERS-CoV, and only supportive care is available. Our study aimed to address this therapeutic gap by developing a potent neutralizing bispecific antibody (bsAb) against MERS-CoV.

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  • - The study aims to create a consensus in the Asia-Pacific region on long-term management and sequential therapy for osteoporosis, focusing on effective fracture prevention through individualized treatment strategies.
  • - A panel of experts analyzed current literature and expert opinions, resulting in 12 key recommendations, such as using anabolic agents for high fracture risk patients and switching to antiresorptive agents post-anabolic therapy if needed.
  • - The findings offer a cost-effective framework for osteoporosis management, emphasizing shared decision-making and integration of local healthcare systems to enhance patient care in the Asia-Pacific region.
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Ca is a key secondary messenger that determines sperm motility patterns. Mammalian sperm undergo capacitation, a process to acquire fertilizing ability, in the female reproductive tract. Capacitated sperm change their flagellar waveform to develop hyperactivated motility, which is crucial for successful sperm navigation to the eggs and fertilization.

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Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Drugs that increase or maintain dopamine levels in the brain could be a therapeutic strategy for AD. However, the effects of dopamine and its precursor levodopa (L-DOPA) on Aβ/tau pathology in vivo and the underlying molecular mechanisms have not been studied in detail.

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Objective: Breast cancer poses a significant health threat globally and particularly in Korea, where mortality rates have risen notably. In this study, we analyzed the characteristics of breast cancer patients discharged in Korea over the past 15 years and explored the association between comorbidities and treatment outcomes to propose effective strategies for managing cancer patients. Understanding these dynamics is vital for informing tailored management strategies and optimizing healthcare system sustainability.

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  • The Aryl hydrocarbon receptor (AhR) is a key transcription factor involved in tumor progression and immune response, but its distribution in tumors and immune cells is not well understood.
  • This study utilized advanced techniques to analyze AhR expression in 513 patient samples, revealing that it is mainly found in cancer cells, with some presence in immune cells like T cells and macrophages.
  • The results categorized AhR expression patterns by cancer type, particularly highlighting high levels in regulatory T cells in non-small cell lung cancer, providing insights for future clinical trials on AhR-targeting therapies.
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Hypothyroidism is more common in women and individuals between 30 and 50 years old. This case report depicts the clinical outcomes of MOK pharmacopuncture, a type of Korean medicine treatment, for an elderly male patient with hypothyroidism who was on long-term L-thyroxine (LT4) therapy but still felt chronically lethargic and tired and was generally in poor health. A 72-year-old Korean man has been on LT4 since being diagnosed with hypothyroidism 16 years ago and has tried to discontinue hormone supplements in the past.

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  • - Electrostatic capacitors are essential for modern electronics and high-power systems due to their rapid charging and discharging abilities.
  • - Ferroelectric materials, while offering strong polarization, face challenges in energy storage due to high remnant polarization and loss of crystallinity.
  • - The new approach utilizes 2D materials in heterostructures to better control the relaxation time and enhance energy density to 191.7 J/cm³ with over 90% efficiency, paving the way for improved energy storage technologies.
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Colorectal endoscopic submucosal dissection (ESD) is a promising but challenging procedure. It is not widely performed due to its technical difficulty. We aimed to find the predictive factors associated with technical difficulty in colorectal ESD before the procedure.

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Objectives: This study was aimed to assess the preliminary outcomes of radiofrequency ablation (RFA) using a newly developed catheter (VENISTAR) for the treatment of incompetent great saphenous veins (GSVs).

Methods: In this prospective observational study, endovenous RFA using a VENISTAR catheter was performed on 16 saphenous veins in 12 patients between August and November 2019. Patients' pre- and post-procedural data were recorded.

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The visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting vagal sensory neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. A small subset of vagal sensory neurons in both the left and right ganglia innervate the liver and project centrally to the nucleus of the tractus solitarius, area postrema, and dorsal motor nucleus of the vagus, and peripherally to the periportal areas in the liver.

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  • The study evaluates how well GPT-4 can extract liver cancer-related information (LI-RADS features) from MRI reports written in both Korean and English.
  • Researchers created 160 fake reports and considered both these and genuine reports to test the model's accuracy in extracting the relevant data.
  • Results showed high accuracy (up to 99% for some features), but the model still needs improvements for consistency and effectiveness in real-world applications.
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Nanopatterning driven by electrohydrodynamic (EHD) instability can aid in the resolution of the drawbacks inherent in conventional imprinting or other molding methods. This is because EHD force negates the requirement of physical contact and is easily tuned. However, its potential has not examined owing to the limited size of the pattern replica (several to tens of micrometers).

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