Emotion Recognition Using PPG Signals of Smartwatch on Purpose of Threat Detection.

This paper proposes a machine learning approach to detect threats using short-term PPG (photoplethysmogram) signals from a commercial smartwatch. In supervised learning, having accurately annotated training data is essential. However, a key challenge in the threat detection problem is the uncertainty regarding how accurately data labeled as 'threat' reflect actual threat responses since participants may react differently to the same experiments.

A scientific-article key-insight extraction system based on multi-actor of fine-tuned open-source large language models.

The exponential growth of scientific articles has presented challenges in information organization and extraction. Automation is urgently needed to streamline literature reviews and enhance insight extraction. We explore the potential of Large Language Models (LLMs) in key-insights extraction from scientific articles, including OpenAI's GPT-4.

Synergistic enhancement of spinal fusion in preclinical models using low-dose rhBMP-2 and stromal vascular fraction in an injectable hydrogel composite.

Spinal fusion surgery remains a significant challenge due to limitations in current bone graft materials, particularly in terms of bioactivity, integration, and safety. This study presents an innovative approach using an injectable hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) hydrogel combined with stromal vascular fraction (SVF) and low-dose recombinant human BMP-2 (rhBMP-2) to enhance osteodifferentiation and angiogenesis. Through a series of in vitro studies and preclinical models involving rats and minipigs, we demonstrated that the hydrogel system enables the sustained release of rhBMP-2, resulting in significantly improved bone density and integration, alongside reduced inflammatory responses.

Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis.

Introduction: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune responses and metabolism induced by these variants.

Methods: Here, metabolomics combined with transcriptomics was performed to elucidate the immunometabolic changes in the lung of hamsters infected with delta and omicron variants.

PFSH-Net: Parallel frequency-spatial hybrid network for segmentation of kidney stones in pre-contrast computed tomography images of dogs.

Kidney stone is a common urological disease in dogs and can lead to serious complications such as pyelonephritis and kidney failure. However, manual diagnosis involves a lot of burdens on radiologists and may cause human errors due to fatigue. Automated methods using deep learning models have been explored to overcome this limitation.

Amygdala-centered emotional processing in Prolonged Grief Disorder: Relationship with clinical symptomatology.

Background: Prolonged Grief Disorder is a multidimensional condition with adverse health consequences. We hypothesized that enhanced negative emotional bias characterizes this disorder and underlies its key clinical symptoms.

Methods: In a cross-sectional design, chronically grieving older adults (61.

Long-Chain Polysaturated Fatty Acid in Atrial Fibrillation-Associated Stroke: Lipidomic-GWAS Study.

Background and Purpose This study aimed to explore the relationship between lipidomic domains, particularly free fatty acids (FFAs), and the presence of AF in patients with acute stroke, and to identify mechanisms of AF-associated stroke through genetic studies. Methods A total of 483 patients of stroke in patients without AF (n = 391) and with AF (n = 92) were selected from a prospectively collected stroke registry. Lipidomic profiling was conducted and the lipid components associated with AF were explored using fold-change analyses and clustering.

Strategic design of emerging (K,Na)NbO-based perovskites for high-performance piezocatalysis and photo-piezocatalysis.

As a leading Pb-free perovskite material (ABO-type), potassium sodium niobate (K,Na)NbO (KNN)-based ferroelectrics/piezoelectrics have been widely used in electronics, energy conversion, and storage due to their exceptional ability to interconvert mechanical and electrical energies. Beyond traditional applications, the piezoelectric potential generated by mechanical strain or stress modifies their energy band structures and facilitates charge carrier separation and transport, drawing increasing attention in emerging fields such as piezocatalysis and photo-piezocatalysis. With excellent piezoelectric properties, chemical/thermal stability, and strain-tuning capability, KNN-based materials show great promise for high-performance piezocatalytic applications.

Transparent and visible light-activated antimicrobial air filters from electrospun crystal violet-embedded polyacrylonitrile nanofibers.

Bioaerosols pose significant risks to indoor environments and public health, driving interest in advanced antimicrobial air filtration technologies. Conventional antimicrobial filters often suffer from diminished efficacy over time and require additional binders to retain antimicrobial agents. This study introduces CV@PAN, a self-disinfecting nanofiber fabricated via electrospinning of crystal violet (CV) and polyacrylonitrile (PAN).

Optimal Computed Tomographic Arthrography Protocol for Stifle Ligamentous Structure and Menisci in Dogs.

This study aims to establish an optimized CTA protocol for qualitatively evaluating the ligamentous structures and menisci of the canine stifle. CTA of the stifle joint was conducted on six healthy beagle dogs. Each dog underwent a total of nine scans to evaluate various contrast protocols.

Distinct phenotypes of salivaricin-producing Ligilactobacillus salivarius isolated from the gastrointestinal tract of broiler chickens and laying hens.

Ligilactobacillus salivarius harbors bacteriocin genes in its repA-type megaplasmid, specifically salivaricin P (salP), a class IIb bacteriocin. This study aimed to differentiate 25 salP-positive Lig. salivarius strains isolated from the gastrointestinal tract (GIT) of broilers and laying hens.

Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases.

When used to edit genomes, Cas9 nucleases produce targeted double-strand breaks in DNA. Subsequent DNA-repair pathways can induce large genomic deletions (larger than 100 bp), which constrains the applicability of genome editing. Here we show that Cas9-mediated double-strand breaks induce large deletions at varying frequencies in cancer cell lines, human embryonic stem cells and human primary T cells, and that most deletions are produced by two repair pathways: end resection and DNA-polymerase theta-mediated end joining.

On-DNA Mannich Reaction for DNA-Encoded Library Synthesis.

The β-amino ketones produced through the Mannich reaction hold significant potential as candidates for various drugs. In this study, we optimized on-DNA Mannich reaction conditions and applied them to investigate the reactions of DNA-conjugated aldehydes with various amine and ketone building blocks. The developed on-DNA Mannich reaction preserved the DNA integrity and established viable routes for library production.

Expanding Insights: Harnessing Expansion Microscopy for Super-Resolution Analysis of HIV-1-Cell Interactions.

Expansion microscopy has recently emerged as an alternative technique for achieving high-resolution imaging of biological structures. Improvements in resolution are achieved by physically expanding samples through embedding in a swellable hydrogel before microscopy. However, expansion microscopy has been rarely used in the field of virology.

Improving the Energy Storage Performance in BiNaTiO-Based Ceramics by Combining Relaxor and Antiferroelectric Properties.

Ceramic capacitors have received great attention for use in pulse power systems owing to their ultra-fast charge-discharge rate, good temperature stability, and excellent fatigue resistance. However, the low energy storage density and low breakdown strength (BDS) of ceramic capacitors limit the practical applications of energy storage technologies. In this work, we present a series of relaxor ferroelectric ceramics (1-) [0.

Relationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer's disease neuropathology.

Background: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounced ageing (older brain age) during midlife being indicative of later development of dementia. Here, we examined whether brain-ageing heterogeneity in unimpaired older adults related to neurodegeneration, different cognitive trajectories, genetic and amyloid-beta (Aβ) profiles, and to predicted progression to Alzheimer's disease (AD).

Impact of Chronic Hepatitis C Virus on Acute Kidney Injury After Living Donor Liver Transplantation.

Background: Acute kidney injury (AKI) is one of the most common complications after liver transplantation (LT) and can significantly impact outcomes. The presence of hepatitis C virus (HCV) infection increases the risk of AKI development. However, the impact of HCV on AKI after LT has not been evaluated.

Comprehensive metabolomic analysis identifies key biomarkers and modulators of immunotherapy response in NSCLC patients.

Although immune checkpoint inhibitors (ICIs) have revolutionized immuno-oncology with effective clinical responses, only 30 to 40 % of patients respond to ICIs, highlighting the need for reliable biomarkers to predict and enhance therapeutic outcomes. This study investigated how amino acid, glycolysis, and bile acid metabolism affect ICI efficacy in non-small cell lung cancer (NSCLC) patients. Through targeted metabolomic profiling and machine learning analysis, we identified amino acid metabolism as a key factor, with histidine (His) linked to favorable outcomes and homocysteine (HCys), phenylalanine (Phe), and sarcosine (Sar) linked to poor outcomes.

UV-B increases active phytochrome B to suppress thermomorphogenesis and enhance UV-B stress tolerance at high temperatures.

Plants respond to slight increases in ambient temperature by altering their architecture, a phenomenon collectively termed thermomorphogenesis. Thermomorphogenesis helps mitigate the damage caused by potentially harmful high-temperature conditions and is modulated by multiple environmental factors. Among these factors, ultraviolet-B (UV-B) light has been shown to strongly suppress this response.

Long-Run Impacts of an Early-life Nutrition Program: Evidence from the Introduction of the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC).

Objectives: To study how access to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) during the prenatal and early childhood periods affects long-term health outcomes of the affected cohorts.

Methods: In order to identify the effects of the WIC program, we exploit variations in the timing of its introduction in different counties and analyze future health indicators of affected cohorts. We use the restricted version of the Panel Study of Income Dynamics, which includes county-level identifiers through the interview year 2019.