Publications by authors named "Hwan-Ju Kim"
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses in the global swine industry due to its high genetic diversity and different virulence levels, which complicate disease management and vaccine development. This study evaluated longitudinal changes in the immune cell composition of bronchoalveolar lavage fluid and the clinical outcomes across PRRSV strains with varying virulence, using techniques including single-cell transcriptomics. In highly virulent infection, faster viral replication results in an earlier peak lung-damage time point, marked by significant interstitial pneumonia, a significant decrease in macrophages, and an influx of lymphocytes.
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- Caseous lymphadenitis (CLA) is a bacterial disease affecting ruminants that has seen a rise in cases in South Korea since 2014, prompting the development of a new vaccine.
- Researchers created the first inactivated CLA vaccine in South Korea and tested its effectiveness through trials on mice, guinea pigs, and Korean Native Black Goats (KNBGs), finding no clinical symptoms in vaccinated KNBGs and significant levels of CLA-specific IgG.
- The vaccine is designed to prevent infection from a variety of CLA strains, with the potential to protect livestock and support the growth of the domestic KNBG industry in South Korea.
Porcine reproductive and respiratory syndrome (PRRS) is a disease that has inflicted economic losses in the swine industry. The causative agent, porcine reproductive and respiratory syndrome virus (PRRSV), is known to have a high genetic diversity which leads to heterogeneous pathogenicity. To date, the impact of PRRS outbreaks on swine production and the economy of the swine industry in South Korea has been rarely reported.
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