Sex-specific risk assessment of PFHxS using a physiologically based pharmacokinetic model.

Perfluorohexanesulfonate (PFHxS), which belongs to the group of perfluoroalkyl and polyfluoroalkyl substances (PFASs), has been extensively used in industry and subsequently detected in the environment. Its use may be problematic, as PFHxS is known to induce neuronal cell death, and has been associated with early onset menopause in women and with attention deficit/hyperactivity disorder. Due to these impending issues, the aim of this study is to develop and evaluate a physiologically based pharmacokinetic (PBPK) model for PFHxS in male and female rats, and apply this to a human health risk assessment.

A sensitive UHPLC-MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study.

The aim of this study was to develop an analytical method to simultaneously analyze schizandrin, schizandrol B, and gomisin N lignans in human plasma using ultra high performance liquid chromatography with tandem mass spectrometry. The three lignans were separated using a mobile phase of water and acetonitrile containing 0.02% acetic acid equipped with a Kinetex C column (2.

Kangaroo care on premature infant growth and maternal attachment and post-partum depression in South Korea.

After births, premature infants need a high level of medical treatments for their survivals in the neonatal intensive care unit (NICU). This separation deprives mothers of the chance to initiate an attachment process. Kangaroo care (KC) can be one of the ways to reunite mothers and their infants in the NICU and improve health outcomes.