Artificial intelligence-based prescription of personalized scalp cosmetics improved the scalp condition: efficacy results from 100 participants.

Scalp-related symptoms such as dandruff and itching are common with diverse underlying etiologies. We previously proposed a novel classification and scoring system for scalp conditions, called the scalp photographic index (SPI); it grades five scalp features using trichoscopic images with good reliability. However, it requires trained evaluators.

Antiviral Mechanisms of Saucerneol from against Enterovirus A71, Coxsackievirus A16, and Coxsackievirus B3: Role of Mitochondrial ROS and the STING/TKB-1/IRF3 Pathway.

Enterovirus A71 (EV71), coxsackievirus A16 (CVA16), and coxsackievirus B3 (CVB3) are pathogenic members of the family that cause a range of diseases, including severe central nervous system complications, myocarditis, and pancreatitis. Despite the considerable public health impact of these viruses, no approved antiviral treatments are currently available. In the present study, we confirmed the potential of saucerneol, a compound derived from , as an antiviral agent against EV71, CVA16, and CVB3.

Changes in Care Use and Financial Status Associated With Dementia in Older Adults.

Importance: Estimating the effects of dementia on care use and financial outcomes is timely, as the population with dementia will more than double in the next few decades.

Objective: To determine the incremental changes associated with dementia in regard to older adults' care use and assess financial consequences for individuals, families, and society.

Design, Setting, And Participants: This population-based cohort study included propensity score matching on national, longitudinal data using extensive baseline variables of sociodemographic characteristics, economic status, family availability, health conditions, disability status, and outpatient care use among 2 groups of US adults aged 55 years or older who did not have dementia.

Antioxidant, Collagenase Inhibitory, and Antibacterial Effects of Bioactive Peptides Derived from Enzymatic Hydrolysate of .

The protein extract of hydrolyzed with Alcalase and Flavourzyme was found to have multi-functional properties, including total antioxidant capacity (TAC), collagenase inhibitory, and antibacterial activities. The #5 fraction (SP5) and #7 fraction (SP7) of hydrolysate from cation-exchange chromatography displayed significantly high TAC, collagenase inhibitory, and antibacterial effects against , and only the Q3 fraction from anion-exchange chromatography displayed high multi-functional activities. Eight of 42 peptides identified by MALDI-TOF/MS and Q-TOF/MS/MS were selected from the results for screening with molecular docking on target proteins and were then synthesized.

Measuring spatial availability of children for older adults with disability.

Background: Having an adult child living with or nearby may prevent parents with disability from moving to nursing homes and reduce the use of paid care services. Despite the profound implications for care resources and utilization among older adults, there is no measure summarizing the spatial availability of all adult children for an older adult. Our study aims to develop a holistic measure of adult children's spatial availability to assess potential family care resources for older adults with disability.

Topical application of cream containing enriched-schizandrin from Schisandra chinensis fruit exert anti-photoaging efficacy in ultraviolet B-irradicated hairless mice.

Excessive ultraviolet (UV) B irradiation induced skin photoaging. The aim of this study was to evaluate the anti-photoaging efficacy of enriched-schizandrin from Schisandra chinensis fruit in UVB-induced hairless mice. The cream containing enriched-schizandrin from S.

Association of Arts Event Attendance With Cognitive Function Among Older Adults Enrolled in the Health and Retirement Study.

Background And Objectives: Among the cognitively impaired, arts engagement is associated with improved neurocognitive symptoms. Less is known about arts engagement as a potentially modifiable lifestyle factor to prevent or slow cognitive decline. Our aim was to evaluate the association between arts event attendance and cognition.

Differential Trends in Disability Among Rich and Poor Adults in the United States and England From 2002 to 2016.

Objectives: Disability in the United States has not improved in recent decades. Comparing temporal trends in disability prevalence across different income groups, both within and between the United States and England, would inform public policy aimed at reducing disparities in disability.

Methods: Using the Health and Retirement Study and the English Longitudinal Study of Ageing, we estimated annual percent change from 2002 to 2016 in disability among community-dwelling adults (197,021 person-years of observations).

The Changing Tides of Caregiving During the COVID-19 Pandemic: How Decreasing and Increasing Care Provision Relates to Caregiver Well-Being.

Objectives: Pandemic-specific changes to the caregiving context (e.g., attempts to reduce exposure, physical distancing requirements) may lead to changes in care provision.

Close enough? Adult child-to-parent caregiving and residential proximity.

Adult children are among the most frequent providers for community-dwelling older adults with a disability. This report assesses the extent to which help received from an adult child by older persons with a disability is contingent on the distance between their residences. Using the national Panel Study of Income Dynamics, we selected persons 55 and older with a disability and their adult children (810 older adults; 1767 dyads of older adult - adult child pairs).

Family Care Availability And Implications For Informal And Formal Care Used By Adults With Dementia In The US.

Despite the important role that family members can play in dementia care, little is known about the association between the availability of family members and the type of care, informal (unpaid) or formal (paid), that is actually delivered to older adults with dementia in the US. Using data about older adults with dementia from the Health and Retirement Study, we found significantly lower spousal availability but greater adult child availability among women versus men, non-Hispanic Blacks versus non-Hispanic Whites, and people with lower versus higher socioeconomic status. Adults with dementia and disability who have greater family availability were significantly more likely to receive informal care and less likely to use formal care.

Race/ethnic Differences in Spatial Distance between Adult Children and Their Mothers.

Objective: This brief study examines race/ethnic differences in geographic distance to mothers among adults in the U.S.

Background: Race/ethnic differences in rates of adult children living with their mothers in the U.

Relationship between county-level crime and diabetes: Mediating effect of physical inactivity.

This paper assessed the extent to which physical inactivity accounts for the relationship between the crime rate and prevalence of type 2 diabetes in the United States. Using 2018 US county-level data, we compared unadjusted and adjusted prevalence of type 2 diabetes between high and low crime counties for 2,966 US counties. Average causal mediating effects of residents' reported physical inactivity were estimated for each comparison.

Early Cognitive Decline and its Impact on Spouse's Loneliness.

Background: Loneliness is common in dementia caregivers as cognitive impairment (CI) alters marital and social relationships. Unexplored is how an individual's loneliness is affected at earlier, more ambiguous, periods of their spouse's CI.

Methods: Using the Health and Retirement Study, our study participants included 2,206 coupled individuals with normal cognitive function at the 2006/8 baseline.

Spatial Distance between Parents and Adult Children in the United States.

Objective: This brief report presents contemporary national estimates of the spatial distance between residences of parents and adult children in the United States, including distance to one's nearest parent and/or adult child and whether one lives near all of their parents and adult children.

Background: The most recent national estimates of parent-child spatial proximity come from data for the early 1990s. Moreover, research has rarely assessed spatial clustering of all parents and adult children.

Comparison of Health Outcomes Among High- and Low-Income Adults Aged 55 to 64 Years in the US vs England.

Importance: Socioeconomic differences in life expectancy, health, and disability have been found in European countries as well as in the US. Identifying the extent and pattern of health disparities, both within and across the US and England, may be important for informing public health and public policy aimed at reducing these disparities.

Objective: To compare the health of US adults aged 55 to 64 years with the health of their peers in England across the high and low ranges of income in each country.

Synthesis of 5-Aminolevulinic Acid-Based ALACELL Possessing Inhibitory Effect against : Whitening Effect and Protective Effect of UVB-Irradiated Damage Cells.

Five-aminolevulinic acid (5-ALA)-photodynamic therapy combined with infrared radiation is an effective and safe therapy for facial acne. Although there are various available agents for treating acne, therapies for resistant or severe strains have been limited. The aim of this study was to investigate the inhibitory efficacy of ALACELL synthesized by combining 5-ALA with Y-G-G-F-L peptide against , , , and , as well as .

The Relationship of Loneliness to End-of-Life Experience in Older Americans: A Cohort Study.

Objectives: Little is known about the relationship between loneliness and end-of-life (EOL) experience including symptom burden, intensity of care, and advance care planning among older adults.

Design: Secondary analysis of the Health and Retirement Study (HRS).

Setting: Population based.

Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway.

Coxsackievirus B3 (CVB3) is an important human pathogen associated with the development of acute pancreatitis, myocarditis, and type 1 diabetes. Currently, no vaccines or antiviral therapeutics are approved for the prevention and treatment of CVB3 infection. We found that Saururus chinensis Baill extract showed critical antiviral activity against CVB3 infection in vitro.

Anti-photoaging effect of skin cream manufactured with ziyuglycoside I isolated from on ultraviolet B-induced hairless mice.

In this study, skin cream containing ziyuglycoside I isolated from was manufactured and examined the protective effects of the skin cream against UVB-induced hairless mice. UVB-induced hairless mice were topically treated with the skin cream once a day for 5 weeks. Application of the skin cream did not exhibit side effect on body growth showing normal body weight and food efficiency in the mice.

Health Risk Behaviors after Disaster Exposure Among Older Adults.

Objective: The aim of this study was to examine the extent to which an exposure to disaster is associated with change in health behaviors.

Methods: Federal disaster declarations were matched at the county-level to self-reported behaviors for participants in the Health and Retirement Study (HRS), 2000-2014. Multivariable logistic regression was used to evaluate the relationship between disaster and change in physical activity, body mass index (BMI), and cigarette smoking.