Metoprolol abolishes exercise-induced left ventricular dysfunction in patients with silent ischemia.

Left ventricular systolic function is reduced during episodes of silent ischemia in patients with coronary artery disease (CAD). Left ventricular ejection fraction (LVEF) is increased at least 5 absolute percent during exercise in most normal subjects; however, in patients with CAD, LVEF often remains unchanged or decreases. The anti-ischemic effect of beta-adrenergic receptor blockade is well documented, including a reduction of exercise-induced electrocardiographic ST depressions; however, the effect of these drugs on left ventricular volume changes during exercise in patients with silent ischemia is unknown.

Carcinoid tumour of the breast.

A case of primary carcinoid in the female breast is reported. The patient was treated by segmental mastectomy and is without local recurrence and signs of carcinoid tumour at any other site after 3 years of observation.

Impact of immediate and delayed myocardial scintigraphy on therapeutic decisions in suspected acute myocardial infarction.

Early myocardial scintigraphic imaging has become technically feasible in patients admitted to hospital with suspected acute myocardial infarction. After prompt injection of 99mTc-sestamibi, subsequent scintigraphic imaging of perfused myocardium can be performed. During a 5-month period, 237 patients were admitted to the coronary care unit of a district hospital on suspicion of acute ischaemic syndrome, and injection of 99mTc-sestamibi for the performance of myocardial scintigraphy was carried out in 134 patients, on average 2 h after onset of symptoms.

[The value of bone marrow scintigraphy in patients with recurrent breast cancer].

Attempts were made to assess the value of various methods of demonstration of bone metastases in patients with recurrence of cancer of the breast. A material of 123 patients with suspected or verified recurrence of cancer of the breast was submitted to a programme of investigation consisting of conventional X-ray survey of the axial skeleton and thorax, bone tissue scintigraphy, bone marrow scintigraphy, bone biopsy and aspiration of marrow and blood status including serum alkaline phosphatase. 54% and 29% of the patients had bone, metastases as assessed radiographically and by biopsy, respectively.

Spleen emptying and venous hematocrit in humans during exercise.

The spleen may release pooled erythrocytes to the general circulation during strenuous conditions such as heavy exercise. Most of our knowledge of this reservoir function of the spleen derives from animal studies, and the splenic contribution to the circulating blood volume in humans has been regarded as unimportant. We recorded the erythrocyte content in the human spleen during graded bicycle exercise to maximal working capacity.

Leucocyte scintigraphy to localize inflammatory activity in ulcerative colitis and Crohn's disease.

The validity of using autologous leucocytes labelled with technetium -99m hexamethyl-propyleneamine-oxine (Tc-HMPAO) for scintigraphy in inflammatory bowel disease was evaluated in 12 patients with clinically active ulcerative colitis (UC) and 10 with Crohn's disease (CD). Colonoscopy and biopsy were used as reference. Scintigrams taken 1 h and 3 h after leucocyte reinjection were evaluated blindly by two independent observer groups.

Myocardial perfusion at fatal infarction: location and size of scintigraphic defects.

In a consecutive study of myocardial scintigraphy in acute ischemic syndrome, four patients had 99mTc-hexamibi injected intravenously before they developed fatal cardiogenic shock. Planar scintigraphy was performed after death. Slices of the hearts after autopsy were analyzed for scintigraphic and pathoanatomic abnormalities.

Reliability of first-pass radionuclide determination of cardiac output in the upright position at rest and during exercise.

The reliability of non-invasive determination of cardiac output using first-pass radionuclide cardiography at rest and during exercise in the upright position was evaluated in 20 patients with coronary artery disease. Cardiac output values ranged from 2.97 to 5.

Effects of atropine on left ventricular volumes and ejection and filling rates at rest and during exercise.

1. The influence of the parasympathetic nervous system on left ventricular function including ejection and filling rates was studied by radionuclide cardiography in eight healthy young men at rest and during upright exercise. 2.

Estimation of glomerular filtration rate from low-dose injection of iohexol and a single blood sample.

Clearance of a small dose of iohexol (7 g I) was compared with the glomerular filtration rate (GFR) marker 51Cr EDTA in 11 healthy volunteers. The two tracers were injected simultaneously. The plasma concentration of iohexol was measured with x-ray fluorescence technique.

Observer variation in the scintigraphic diagnosis of solitary cold thyroid lesions.

In order to evaluate the reproducibility of the diagnosis of solitary cold thyroid lesions, two specialists in nuclear medicine and two specialists in endocrinology independently twice read 240 thyroid 99mTc pertechnetate scintigrams. No significant difference or interaction between the results obtained from the right and the left lobe was found. A solitary cold lesion was diagnosed in 100 of the 480 lobes; however, in only 30 did all four observers agree upon the diagnosis.

65 zinc absorption in patients with insulin-dependent diabetes mellitus assessed by whole-body counting technique.

The gastrointestinal absorption of zinc was measured in patients with insulin-dependent diabetes mellitus. The concentration of zinc in serum was similar to healthy individuals. However the urinary excretion rate of zinc relative to the creatinine excretion, was approximately doubled (p less than 0.

Observer variation in the assessment of scintigraphy of the thyroid gland.

In order to determine observer variation in the assessment of thyroid scintigrams two specialists in nuclear medicine and two specialists in endocrinology independently evaluated 240 thyroid pertechnetate scintigrams twice, and assessed a number of variables concerning size and isotope uptake. The observed agreement between pairs of observers for the variables ranged from 0.70 to 0.

Gastric emptying and subjective symptoms of nausea: lack of effects of a 5-hydroxytryptamine-3 antagonist ondansetron on gastric emptying in patients with gastric stasis syndrome.

Thirty-seven consecutive patients referred to a regional gastroenterology outpatient clinic with complaints of persistent nausea had a double isotopic scintigraphic evaluation of solid and liquid gastric emptying. Gastric emptying of both forms followed an exponential model. Marked day to day variation of gastric emptying was noted with a coefficient of variation of approximately 0.

Diuresis renography. A simultaneous comparison between 131I-hippuran and 99Tcm-MAG3.

In 20 patients investigated for unilateral upper urinary tract obstruction diuresis renography was performed simultaneously with 131I-hippuran and 99Tcm-MAG3 using a gamma camera with dual isotope facilities. Furosemide was administered routinely 20 min after radionuclide injection. No significant differences were found in fractional share between the two kidneys, time to maximal activity, residual activity at 20 and 30 min, or rate of emptying after furosemide administration.

[Mesenteric cysts in Denmark in 1980-86].

On the basis of a material of mesenteric cysts from a period of six years in all Denmark, the symptomatology, diagnosis and treatment of mesenteric cysts (MC) are described. These cysts are rare: approximately one par 130,000 somatic admissions. Mesenteric cysts may be encountered along the entire gastro-intestinal canal from the duodenum to the rectum but are, however, most frequent in the mesentery of the small intestine.

Scintigraphic demonstration of the thoracic duct following oral ingestion of 123I-heptadecanoic acid.

A new noninvasive method for scintigraphic demonstration of the anatomic localization and function of the thoracic duct is described. Seven volunteers ingested 123I-heptadecanoic acid; approximately one hour later the entire thoracic duct was demonstrated and correspondingly a sharp rise in the plasma appearance rate of radioactivity was recorded. The method is simple and without side effects.

Validity of renal split function by single probe renography in hypertensive patients. A comparison with gamma camera scintigraphy.

Single kidney function was determined both by single probe renography (131I hippuran) and gamma camera scintigraphy (99Tcm DMSA) in the sitting position in 42 consecutive patients who were referred to renography as a part of the workup of their hypertension. The positioning of the detectors turned out to be satisfactory in 83 per cent of the patients when compared with the determination of the split function at scintigraphy. This might be explained by the small 100 per cent isocount area of the probe (avoiding the effect of mobile kidneys) and by the 4-channel localization system.

Scintigraphic control of pulmonary embolism.

Pulmonary embolism was diagnosed by combined perfusion and ventilation scintigraphy in 30 patients. A control examination 6 months later revealed pulmonary embolism or infarction in 8, in spite of conventional treatment. Therefore, patients treated for pulmonary embolism should be reexamined 3 to 6 months after diagnosis.

Long-term follow-up of right ventricular function after Mustard operation for transposition of the great arteries.

As development of right ventricular (RV) failure is a potential risk after Mustard operation for transposition of the great arteries, 17 patients were reexamined 5-13 years postoperatively. Comparisons were made with healthy controls. There were no clinical signs of heart failure.

Demonstration of the thoracic duct by 123I heptadecanoic acid. Report of a case.

The thoracic duct was visualized following ingestion of 123I heptadecanoic acid in a healthy volunteer and in a patient with a growing chyle cyst. The visualization indicated that operative removal of the cyst would not interfere with the lymphatic drainage from the intestines.

Combination of DMSA-scintigraphy and hippuran renography in unilateral obstructive nephropathy. Improved prediction of recovery after intervention.

The renal handling of dimercaptosuccinic acid and hippuran differs. This might be used in unilateral obstructive nephropathy in order to predict potential functional recovery following intervention. The theory was evaluated on a retrospective basis in 17 patients, who primarily had a nephrostomy.