Preparation and characterization of superporous hydrogel based on different polymers.

Introduction: Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure.

Aim: The synthesis of SPH of poly (acrylamide-co-acrylic acid) and its composites viz. Ac-Di-Sol and polyvinylpyrollidone (PVP) was carried out by solution polymerization.

Preparation and in vitro evaluation of guar gum based triple-layer matrix tablet of diclofenac sodium.

The objective of the present study was to design an oral controlled drug delivery system for sparingly soluble diclofenac sodium (DCL) using guar gum as triple-layer matrix tablets. Matrix tablet granules containing 30% (D1), 40% (D2) or 50% (D3) of guar gum were prepared by the conventional wet granulation technique. Matrix tablets of diclofenac sodium were prepared by compressing three layers one by one.

Preparation and In Vitro Evaluation of a Stomach Specific Drug Delivery System based on Superporous Hydrogel Composite.

This study discusses efforts made to design drug-delivery system based on superporous hydrogel composite for sustained delivery of ranitidine hydrochloride. The characterization studies involve measurement of apparent density, porosity, swelling studies, mechanical strength studies, and scanning electron microscopy. Scanning electron microscopic images clearly showed the formation of interconnected pores, capillary channels, and the cross-linked sodium carboxymethylcellulose molecules around the peripheries of pores.

Effect of crosslinker concentration on characteristics of superporous hydrogel.

Aim: Synthesis of superporous hydrogel with different concentrations of crosslinker was carried out using solution polymerization to study its effect on characteristics of superporous hydrogel. Methylene-bis-acrylamide was used as a crosslinker.

Materials And Methods: The characterization studies were performed by measurement of apparent density, porosity, swelling studies, mechanical strength studies, and scanning electron microscopy analysis.