Publications by authors named "Huzaifa A Cheema"
Background: A conservative strategy is the primary modality of treatment for acute pancreatitis of which fluid replacement is an important component. Since the results regarding early aggressive versus moderate fluid replenishment for acute pancreatitis are inconsistent, we sought to compare outcomes between the two resuscitation strategies in our meta-analysis.
Methods: We searched MEDLINE (PubMed), Embase, the Cochrane Library, and ClinicalTrials.
Efficacy and safety of mavacamten for the treatment of hypertrophic cardiomyopathy: an updated systematic review and meta-analysis of randomized controlled trials.
Ann Med Surg (Lond)
October 2024
The efficacy and safety profile of mavacamten, a cardiac myosin inhibitor for the treatment of hypertrophic cardiomyopathy (HCM) is not well-established, prompting the need for an updated meta-analysis. The authors conducted an extensive search across multiple electronic databases, including Embase, MEDLINE (via Pubmed), and CENTRAL, to identify randomized controlled trials (RCTs) assessing the efficacy and safety of mavacamten in HCM. Review Manager 5.
View Article and Find Full Text PDFObjective: The evidence underlying the efficacy and safety of minimally invasive mitral valve surgery (MIMVS) is inconclusive. We conducted a meta-analysis to evaluate whether MIMVS improves clinical outcomes compared with conventional sternotomy.
Methods: We searched MEDLINE (via PubMed), Embase, the Cochrane Library, and ClinicalTrials.
Article Synopsis
- This study investigates whether sub-lobar resection can be a viable alternative to lobectomy for patients with early-stage non-small cell lung cancer (NSCLC), focusing on those with tumors ≤2 cm.!* -
- After analyzing 27 studies with over 10,000 patients, the results showed that sub-lobar resection had similar overall survival (OS) and disease-free survival (DFS) outcomes compared to lobectomy, although patients in the compromised subgroup had worse DFS with sub-lobar resection.!* -
- Ultimately, while sub-lobar resection did not show overall significant differences in survival or mortality when compared to lobectomy, it indicated poorer outcomes for specific patient groups, particularly those considered compromised.!*
Article Synopsis
- Wilms tumor (WT) survival rates vary significantly, highlighting the need for research into prognostic factors impacting outcomes for patients diagnosed with the disease.
- This study analyzed clinicopathological data from the SEERStat Database, involving 2,273 WT patients, using advanced statistical methods to assess survival trends over time.
- Results showed a high five-year survival rate of 93.6% and identified key factors influencing survival, including age at diagnosis and disease spread, with younger patients exhibiting better outcomes compared to older patients.
Article Synopsis
- The study focuses on Syrian people's understanding and attitudes toward HIV/AIDS and STIs to promote safe sex practices.
- Conducted online between September and November 2022 with over 1,000 participants, it assessed knowledge through a questionnaire covering demographics, knowledge and practice, and attitudes towards these infections.
- Results indicated moderate knowledge levels about STIs and HIV, but negative attitudes remained prevalent, emphasizing the need to address these gaps in lower-income countries like Syria.
Heart failure (HF) patients frequently exhibit iron deficiency, which is associated with a poor prognosis. Although various trials have been conducted, it is uncertain if intravenous (IV) iron replenishment improves clinical outcomes in HF patients with iron deficiency. A comprehensive literature search was conducted using PubMed/MEDLINE, Embase, and the Cochrane Library from inception till 15 September 2023 to retrieve randomized controlled trials (RCTs) that compared IV iron therapy with placebo or standard of care in patients with HF and iron deficiency.
View Article and Find Full Text PDFBackground: Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are superior to coronary angiography for guiding percutaneous coronary intervention (PCI). However, whether one technique is superior to the other is inconclusive.
Methods: We searched PubMed, Embase, the Cochrane Library, and ClinicalTrials.
Background: Since the efficacy and safety of endovascular thrombectomy (EVT) in patients with acute ischemic stroke with a large infarct area is still inconclusive, we sought to compare functional and neurological outcomes with the use of endovascular thrombectomy versus medical care alone.
Methods: We searched MEDLINE (via PubMed), Embase, Cochrane Library, ClinicalTrials.gov, and the International Clinical Trials Registry Platform (ICTRP) to retrieve all the relevant randomized controlled trials (RCTs) on this topic.
Background: Dementia is a recognized complication of atrial fibrillation (AF). Oral anticoagulant (OAC) therapy can potentially be protective against this complication.
Methods: A comprehensive search of MEDLINE and Embase for comparative observational studies reporting the efficacy of OAC therapy for the incidence of dementia in patients with AF was conducted from its inception until March 2023.
Objectives: We conducted an updated systematic review and meta-analysis to investigate the effect of colchicine treatment on clinical outcomes in patients with COVID-19.
Design: Systematic review and meta-analysis.
Data Sources: We searched PubMed, Embase, the Cochrane Library, medRxiv and ClinicalTrials.
Objective: The objective was to evaluate the long-term outcome of microvascular decompression (MVD) utilizing autologous muscle for trigeminal neuralgia (TGN).
Methods: A retrospective review was performed of all first-time MVD patients for typical classic TGN without prior surgical intervention who were treated between 2000 and 2019 at a tertiary supraregional neurosurgery practice. Demographic characteristics, surgical findings, operative results, complications, and recurrence rates at 1 year, 5 years, and last follow-up were collected.
A strategy of complete revascularization (CR) is recommended in patients with acute coronary syndrome (ACS) and multivessel disease (MVD). However, the optimal timing of CR remains equivocal. We searched MEDLINE, Embase, the Cochrane Library, and ClinicalTrials.
View Article and Find Full Text PDFMolnupiravir for the treatment of COVID-19 outpatients: An updated meta-analysis.
J Microbiol Immunol Infect
June 2024
Background: The majority of available data on molnupiravir come from an unvaccinated COVID-19 population. Therefore, we conducted this meta-analysis to integrate evidence from recent randomized controlled trials (RCTs) as well as observational studies stratified by vaccination status to determine the clinical efficacy and safety of molnupiravir in COVID-19 outpatients.
Methods: We searched PubMed, Embase, the Cochrane Library, medRxiv, and ClinicalTrials.
is an herbal therapy for various afflictions. It has some potential to be a promising option as an efficacious treatment for COVID-19 patients that can contribute to global healthcare as a relatively cheap therapy but evidence of its use from randomized controlled trials (RCTs) is limited. Therefore, to explore the effect of in combating COVID-19, we undertook this meta-analysis.
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- Individuals with a Prior Cancer History (PCH) are often excluded from clinical trials, but evidence suggests their past cancer history might not significantly affect their survival in brain cancer cases.
- A retrospective study analyzed data from 42,726 brain cancer patients, with 2.78% having a PCH, highlighting genitourinary and breast cancers as the most common prior types.
- While PCH was found to significantly increase the overall survival risk, it did not significantly impact brain cancer-specific survival, particularly in patients with glioblastoma or prior gastrointestinal and hematologic malignancies.
Outcomes in systemic sclerosis patients hospitalized with COVID-19: Insight from the National Inpatient Sample.
J Scleroderma Relat Disord
February 2024
Objective: COVID-19, a respiratory infection caused by the novel coronavirus SARS-CoV-2, can cause varying degrees of illness ranging from mild respiratory illness to severe respiratory failure. Systemic sclerosis is a chronic autoimmune disease, with an increased prevalence of infections as compared to the general population. In this study, we compare the clinical outcomes and resource utilization for COVID-19 hospitalizations in patients with and without systemic sclerosis.
View Article and Find Full Text PDFBackground: The role of corticosteroids in the treatment of community-acquired pneumonia (CAP) remains uncertain. We conducted an updated meta-analysis to investigate the effectiveness and potential effect modifiers of adjunctive corticosteroids in patients with CAP.
Methods: The protocol of this meta-analysis was registered with PROSPERO (CRD42022354920).
Article Synopsis
- Menopause often results in symptoms like hot flashes and night sweats, which can be troublesome, and while hormonal therapy has been a traditional treatment, it poses safety concerns.* -
- This analysis aims to assess the effectiveness and safety of fezolinetant, a neurokinin-3 antagonist, in alleviating postmenopausal vasomotor symptoms (VMS) through a thorough review of existing studies.* -
- Findings indicate that fezolinetant significantly reduces the frequency and severity of VMS and improves quality of life metrics, with no major safety issues reported, though a slight increase in treatment-emergent adverse effects was noted.*
Background: Although numerous modalities are currently in use for the treatment and prophylaxis of COVID-19, probiotics are a cost-effective alternative that could be used in diverse clinical settings. Hence, we conducted a meta-analysis to investigate the role of probiotics in preventing and treating COVID-19 infection.
Methods: We searched several databases from inception to 30 May 2023 for all randomized controlled trials (RCTs) and comparative observational studies that evaluated probiotics (irrespective of the regimen) for the treatment or prevention of COVID-19.
Background: Prehospital tranexamic acid (TXA) may hold substantial benefits for trauma patients; however, the data underlying its efficacy and safety is scarce.
Methods: We searched PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov from inception to July 2023 for all randomized controlled trials (RCTs) investigating prehospital TXA in trauma patients as compared to placebo or standard care without TXA.
Brain metastasis in gastric cancer (GC) patients is a rare phenomenon that is associated with adverse clinical outcomes and poor survival rates. We conducted a retrospective cohort study to investigate the incidence, risk factors and prognostic factors of brain metastasis in GC patients. Data on sociodemographic and tumor characteristics of GC patients from 2010 to 2019 was extracted from the Surveillance, Epidemiology and End-Results (SEER) database.
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