Publications by authors named "Huyen Khanh Le"
Article Synopsis
- A new physiologically based pharmacokinetic (PBPK) model for adeno-associated virus (AAV) therapy was created to improve drug development, based on studies in mice.
- The study examined the distribution of AAV8 and AAV9 vectors and their encoded monoclonal antibody (mAb) over three weeks, revealing tissue-to-blood concentration ratios that varied significantly across different organs.
- The developed PBPK model captures the pharmacokinetics of both the AAV vector and the mAb, highlighting liver, muscle, and heart as key contributors to mAb secretion, and it will aid in preclinical study design and the transition from animal studies to human trials.
Article Synopsis
- Different administration routes for antibody-drug conjugates (ADCs) can affect their pharmacokinetics and pharmacodynamics (PK/PD), potentially improving their effectiveness.
- This study assessed the PK/PD of an ADC (trastuzumab-vc-MMAE) using subcutaneous (SC) and intratumoral (IT) delivery methods in an animal model.
- Findings show that IT administration improves tumor exposure and anti-tumor activity compared to SC, suggesting IT could match IV efficacy with fewer side effects, while SC administration resulted in local toxicity and reduced effectiveness.
