Publications by authors named "Huybert J F van de Stadt"
Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial.
Nat Med
January 2025
Malaria vaccines consisting of metabolically active Plasmodium falciparum (Pf) sporozoites can offer improved protection compared with currently deployed subunit vaccines. In a previous study, we demonstrated the superior protective efficacy of a three-dose regimen of late-arresting genetically attenuated parasites administered by mosquito bite (GA2-MB) compared with early-arresting counterparts (GA1-MB) against a homologous controlled human malaria infection. Encouraged by these results, we explored the potency of a single GA2-MB immunization in a placebo-controlled randomized trial.
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- Disturbed flow contributes to endothelial dysfunction in intimal hyperplasia, commonly found in vascular grafts, leading to adverse vascular conditions.
- This study introduces a new bypass flow model that simulates disturbed flow and various hemodynamic patterns using pulsatile flow.
- Using computational fluid dynamics (CFD), researchers validated the model by showing that human endothelial cells exposed to disturbed flow exhibited significant changes in morphology and activation compared to cells in regular or stagnant flow, highlighting the model's potential for studying vascular diseases.
Article Synopsis
- Hemodialysis patients often use arteriovenous fistulas (AVFs) for dialysis access, but high blood flow through AVFs can lead to complications over time.
- A new implantable device with a magnetic ring was developed to non-invasively control an AVF valve by transmitting torque, and tests were successfully conducted on arm and sheep cadavers.
- The prototype demonstrated effective valve closure capabilities through varying skin thicknesses, indicating its potential for non-invasive control and prompting the need for in vivo studies to evaluate its practical functionality.
A realistic 3-D gated cardiac phantom with known left ventricular (LV) volumes and ejection fractions (EFs) was produced to evaluate quantitative measurements obtained from gated myocardial single-photon emission tomography (SPET). The 3-D gated cardiac phantom was designed and constructed to fit into the Data Spectrum anthropomorphic torso phantom. Flexible silicone membranes form the inner and outer walls of the simulated left ventricle.
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