Publications by authors named "Huy Nguyenhuu"
Article Synopsis
- Understanding the kinetics and thermodynamics of chemical interactions at the phospholipid bilayer is essential for drug-delivery development.
- Researchers employed molecular dynamics simulations and SHG spectroscopy to investigate how the small organic cation, malachite green, interacts with DOPG liposomes in water under varying temperatures.
- The study found that adsorption is exothermic and increases entropy, with faster molecular transport at higher temperatures, and the MD simulations matched well with experimental data.
A fundamental understanding of the factors that determine the interactions with and transport of small molecules through phospholipid membranes is crucial in developing liposome-based drug delivery systems. Here we combine time-dependent second harmonic generation (SHG) measurements with molecular dynamics simulations to elucidate the events associated with adsorption and transport of the small molecular cation, malachite green isothiocyanate (MGITC), in colloidal liposomes of different compositions. The molecular transport of MGITC through the liposome bilayer is found to be more rapid in 1,2-dioleoyl--glycero-3-phospho-(1'--glycerol) and 1,2-dioleoyl--glycero-3-phospho-l-serine (DOPG and DOPS, respectively) liposomes, while the molecular transport is slower in 1,2-dioleoyl--glycero-3-phosphocholine (DOPC) liposomes.
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