Heteroaryl Glutarimides and Dihydrouracils as Cereblon Ligand Scaffolds for Molecular Glue Degrader Discovery.

Stabilization of cereblon (CRBN)/neosubstrate complexes with molecular glues followed by degradation of those neosubstrates is an emerging strategy in drug discovery with compelling potential to target certain proteins that were previously considered to be undruggable. In this context, the discovery of novel CRBN ligands is an important area of ongoing research that holds promise to expand the scope of proteins that can be targeted through this mode of action. Herein, we describe the synthesis and evaluation of CRBN ligands featuring heteroaryl glutarimide and dihydrouracil scaffolds.

Safety and Efficacy of Thrombectomy in Vietnamese Stroke Patients Selected Through Perfusion Imaging With an Onset Time Between 6-24 Hours.

Introduction Recent trials have demonstrated the remarkable benefit of endovascular treatment (EVT) up to 24 hour in patients with large vessel occlusion (LVO) and target mismatch profiles; however, benefits of late-window EVT in Vietnamese population remain poorly understood. This study aims to evaluate the real-world outcomes of EVT in acute ischemic stroke (AIS) patients selected using perfusion imaging within the 6- to 24-hour window. Methods A prospective study of consecutive patients with anterior circulation LVO stroke who underwent EVT within 6 to 24 hours after last known well between August 2022 and March 2024.

Planetary Health Booms: Unpacking the Surge in Research Across the Globe Through Joint-Point Analysis.

Planetary Health (PH) is a relatively new field that studies the sciences behind the interaction between the environment, living organisms, and human health. The number of publications in this field has increased exponentially in the past few years. This study analyzed the trend of using the term "PH" in literature.

Single-Incision Combined Laparoscopic Right Hemicolectomy and Cholecystectomy: A Case Report.

Minimally invasive surgery has transformed the management of complex procedures, offering reduced postoperative pain, faster recovery time, and improved cosmetic outcomes. Despite the growing use of minimally invasive techniques, literature specifically addressing single-incision laparoscopic surgery (SILS) for combined hemicolectomy and cholecystectomy is limited. This report seeks to fill this gap by detailing the successful management of a patient case through a single-incision combined laparoscopic right hemicolectomy and cholecystectomy.

Impact of Bond-Slip Models on Debonding Behavior in Strengthened RC Slabs Using Recycled Waste Fishing Net Sheets.

This study investigated the performance of recycled waste fishing net sheets (WSs) as a sustainable strengthening material for reinforced concrete (RC) slabs. The primary challenge addressed is the debonding failure caused by the low bond strength at the WS-to-concrete interface. To analyze this, two full-scale RC slabs-one with and one without strengthening-were cast and tested under a four-point bending setup.

Quantization of the energy for the inhomogeneous Allen-Cahn mean curvature.

We consider the varifold associated to the Allen-Cahn phase transition problem in (or -dimensional Riemannian manifolds with bounded curvature) with integral bounds on the Allen-Cahn mean curvature (first variation of the Allen-Cahn energy) in this paper. It is shown here that there is an equidistribution of energy between the Dirichlet and Potential energy in the phase field limit and that the associated varifold to the total energy converges to an integer rectifiable varifold with mean curvature in . The latter is a diffused version of Allard's convergence theorem for integer rectifiable varifolds.

Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment.

Despite extensive research in chemotherapy, global cancer concerns persist, exacerbated by the challenge of drug resistance, which imposes economic and medical burdens. Natural compounds, particularly secondary metabolites from medicinal plants, present promising avenues for overcoming cancer drug resistance due to their diverse structures and essential pharmacological effects. This review provides a comprehensive exploration of cancer cell resistance mechanisms and target actions for reversing resistance and highlights the and efficacy of noteworthy alkaloids, flavonoids, and other compounds, emphasizing their potential as therapeutic agents.

Reporting ethical approval in case reports and case series in 12 consecutive years: A systematic review.

Our study describes the reported rate of the Institutional Review Board (IRB) approval, declaration of Helsinki (DoH), and informed consent in the case reports and case series and investigates factors associated with the ethical approval report. We searched PubMed for case reports and case series from 2006 to 2017. Annually, we obtained the first 20 articles of a case report cluster from 20 distinct publications.

Near-Complete Reversal of Large Diffusion-Weighted Imaging Lesion after Thrombectomy: A Case Report and Literature Review.

Introduction: Diffusion-weighted imaging (DWI) plays a crucial role in acute ischemic stroke (AIS), as it is used to evaluate the ischemic lesions that are irreversibly damaged. The reversibility of DWI ischemic lesions has been noted in patients with AIS who undergo revascularization therapy. In addition, the occurrence of this phenomenon in large ischemic regions remains rare, particularly the near-complete reversal of large DWI lesion cases.

Assessment of gestational diabetes mellitus knowledge, attitudes, and practices and associated factors among pregnant women at a district hospital in Coastal Kenya.

Background: Gestational diabetes mellitus (GDM) is any degree of glucose intolerance first recognized during pregnancy. GDM awareness among pregnant women translates into GDM prevention and early diagnosis.

Objective: To establish the underlying factors influencing GDM Knowledge Attitude and Practices (KAP) among pregnant women at Kinango District Hospital.

Alpha-glucosidase inhibitory compounds from Vietnamese lichen : and aspects.

Using a bio-guided isolation on the Vietnamese lichen based on alpha-glucosidase inhibition, eleven compounds were isolated and structurally elucidated, namely, protocetraric acid (1), 8'-methylstictic acid (2), stictic acid (3), 4,6-diformyl-8-hydroxy-3-methoxy-1,9-dimethyl-11-oxo-11-dibenzo[,][1,4]dioxepine-7-carboxylic acid (4), vicanicin (5), norstictic acid (6), diffractaic acid (7), barbatic acid (8), atranol (9), 5-chlorohaematommic acid (10), and eumitrin A1 (11). Their chemical structures were identified by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy and compared with those reported in literature. Protocetraric acid (1) and norstictic acid (6) were selected for further modification to derive new compounds, namely, 1a-1e and 6a.

Biodegradation of DDT using multi-species mixtures: From genome-mining prediction to practical assessment.

DDT (dichlorodiphenyltrichloroethane) is a commonly used insecticide that is recalcitrant and highly stable in the environment. Currently, DDT residue contamination, especially in agricultural soil, is still a concern in many countries, threatening human health and the environment. Among the approaches to resolve such an issue, novel biodegradation-based methods are now preferred to physicochemical methods, due to the sustainability and the effectiveness of the former.

Improper disposal of cigarette butts in a southeast Asian megacity (Hanoi, Vietnam): Pollution indexes, distribution profiles, and preliminary physicochemical characterization.

Although Southeast Asia is among the largest producers and consumers of cigarettes in the world, information about environmental contamination with littered cigarette butts (CBs) in this region is very limited, especially in urban areas. In this study, we collected CBs in 58 locations of 6 categories (i.e.

The Changes in the Inner-Structure and Mechanical Strength of the Composite Cement Materials and Silica-Carbon Nanotube-Nylon 66 Electrospun Nanofibers.

This study presents the feasibility of improving some selected mechanical strengths and the inner-structural analyses of cement matrix by electrospun nanofibers containing nylon 66, nanosilica, and carbon nanotube. The hybrid electrospun nanofibers were fabricated and mixed into ordinary Portland cement. From the mechanical strength test results, the hybrid nanofibers have shown their role in improving the tensile, compressive, and toughness behavior of the mixed cement material.

Sterol-lipids enable large-scale, liquid-liquid phase separation in bilayer membranes of only two components.

Despite longstanding excitement and progress toward understanding liquid-liquid phase separation in natural and artificial membranes, fundamental questions have persisted about which molecules are required for this phenomenon. Except in extraordinary circumstances, the smallest number of components that has produced large-scale, liquid-liquid phase separation in bilayers has stubbornly remained at three: a sterol, a phospholipid with ordered chains, and a phospholipid with disordered chains. This requirement of three components is puzzling because only two components are required for liquid-liquid phase separation in lipid monolayers, which resemble half of a bilayer.

CDK5-cyclin B1 regulates mitotic fidelity.

CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p39.