1,3-diarylpyrazolones as potential anticancer agents for non-small cell lung cancer: Synthesis and antiproliferative activity evaluation.

A series of pyrazolone compounds with different substitution patterns have been synthesized using microwave-assisted methods and evaluated their in vitro antiproliferative activity against human lung adenocarcinoma cell lines (A549 and NCI-H522). Among the tested compounds, the pyrazolone P7 exhibited high antiproliferative activity against both A549 and NCIH522 cancer cell lines while being 10 times less cytotoxic to non-cancerous cells. Moreover, our compounds P7 and P11 exhibited higher antiproliferative activity and selectivity against A549 and NCIH522 cells compared with the clinically approved drugs Afatinib and Gefitinib.

Ecotoxicological effects of microplastics on aquatic organisms: a review.

Microplastics   ( <5 mm), which are classified based on primary or secondary sources, are widely distributed in the environment and exert significant effects on aquatic life forms; however, evidence regarding the ecotoxicological effects of microplastics on aquatic organisms is still limited. This research aims at filling a knowledge gap regarding generation sources, distribution, physicochemical properties, and biological behavior of microplastics (MP) in aquatic environments and their interaction with aquatic organisms. The literature indicates that concentrations of MPs observed in such environments are higher than the threshold for safe concentration (6650 buoyant particles/m).

A Customizable Chamber for Measuring Cell Migration.

Cell migration is a vital part of immune responses, growth, and wound healing. Cell migration is a complex process that involves interactions between cells, the extracellular matrix, and soluble and non-soluble chemical factors (e.g.