Steroid control of sexual behavior and brain aromatase in the dove: effects of nonaromatizable androgens, methyltrienolone (R1881), and 5 alpha-dihydrotestosterone.

This study examines the effects of nonaromatizable androgens, methyltrienolone (R1881) and 5 alpha-dihydrotestosterone (DHT) on aggressive courtship and vocal behavior in the male ring dove. Since androgens may influence behavior by increasing the formation of estrogen in the brain, the effects of R1881 and DHT on brain aromatase activity were also studied using an in vitro microassay. Under conditions in which testosterone induced aggressive courtship patterns, the nonaromatizable androgens were ineffective.

Diffuse small noncleaved cell lymphoma in children, Burkitt's versus non-Burkitt's types. Results from the Pediatric Oncology Group and St. Jude Children's Research Hospital.

The clinical relevance of a morphologic distinction between Burkitt's (B) and non-Burkitt's (NB) types of small non-cleaved cell (SNC) non-Hodgkin's lymphoma (NHL) has been controversial. Numerous attempts to discern an important clinical difference between the subtypes have failed to provide a convincing reason to maintain this distinction for other than descriptive purposes. Because of conflicting reports in the literature, the authors have analyzed 183 cases of SNC NHL in children from the Pediatric Oncology Group and 129 from St.

Non-Hodgkin's lymphomas of childhood: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution.

Between 1962 and 1986, a total of 338 consecutive newly diagnosed children and adolescents with non-Hodgkin's lymphomas (NHLs) were evaluated and treated at St Jude Children's Research Hospital (SJCRH). Median follow-up is 6.6 years (range, 1.

Successful treatment of a radiation-associated extradural osteosarcoma with chemotherapy in an adolescent girl.

Bone sarcomas are the most common second malignant neoplasms in survivors of a malignant solid tumor in childhood. In contrast to de novo tumors, secondary bone cancers are typically associated with a poor prognosis, reflecting both a preponderance of primary sites that preclude complete resection in the flat bones of the axial skeleton, and the tendency for local invasiveness or distant metastasis. We describe a patient who developed malignant extradural osteosarcoma of the temporal bone 6 years after successful treatment for a malignant cerebellar astrocytoma with surgical resection and local irradiation.

Non-Hodgkin's lymphoma in children younger than 3 years.

The distribution of histologic subtypes of non-Hodgkin's lymphoma (NHL) in children is known to differ from that in adults, but the histologic characteristics of NHL in very young children have seldom been investigated. The authors retrospectively studied 331 patients with NHL, of whom 16 were younger than 3 years old and found that the distribution of histologic subtypes in the very young patients was similar to that in older children. Six patients had small noncleaved cell lymphomas, five diffuse large cell immunoblastic, four lymphoblastic, and one had a diffuse large noncleaved cell lymphoma.

Ontogeny of testosterone-inducible brain aromatase activity.

The effects of testosterone (T) treatment on androgen-metabolizing enzymes and especially on aromatase were examined in the developing hypothalamus of quail using an in vitro microassay. Testosterone propionate (TP) injected into the pectoral muscles of one-day-old chicks had no effect on formation of 5 alpha-dihydrotestosterone (5 alpha-DHT), 5 beta-dihydrotestosterone (5 beta-DHT) and 5 beta-androstane-3 alpha, 17 beta-diol (5 beta,3 alpha-diol) in the hypothalamus. By contrast, aromatase activity was significantly enhanced in the anterior (PA) and in the posterior (HT) parts of the hypothalamus of these chicks 18-23 h after a single injection of TP.

Serum from patients with non-Hodgkin's lymphoma (NHL) inhibits T-cell colony formation.

This study compared T-cell colony formation in soft agar of lymphocytes from the peripheral blood and lymph nodes of patients with non-Hodgkin's lymphoma (NHL) with T-cell colony formation of peripheral blood lymphocytes from normal individuals. Mononuclear cells were separated from other blood and lymph node elements on density gradient columns, phenotyped for T- and B-cell antigens using monoclonal antibodies, and then plated in soft agar cultures. Lymphocytes from peripheral blood and lymph nodes of patients with NHL exhibited less T-cell colony formation (p less than 0.

Evaluation of coagulation disorders in patients with diseases of Waldeyer's ring.

The presence of pre-existing hemostatic disorders in a surgical patient may pose difficulties in the care of patients during and after surgery. To reduce the risk of excessive hemorrhage, this article has stressed the value of a thorough medical history, physical examination, and appropriate laboratory assays before surgery. When these measures reveal no evidence of a coagulation disorder, the surgeon can have confidence that the patient's hemostatic system has the appropriate resources to prevent excessive bleeding during surgery.

Formation of behaviorally active estrogen in the dove brain: induction of preoptic aromatase by intracranial testosterone.

The preoptic area (POA) of the male ring dove is a target for specific behavioral effects of estrogen that are separable from those of androgen. Activity of the aromatase system in the POA, which converts testosterone to 17 beta-estradiol (E2), is increased by systemic androgen. Using crystalline steroid implants positioned stereotaxically in the brain, we examined whether aromatase induction is a result of direct steroid action on the POA, which can occur independently of the behavioral effects of androgen.

Cerebrospinal fluid centrifuge analysis in primary amebic meningoencephalitis due to Naegleria fowleri.

We describe a case of primary amebic meningoencephalitis due to Naegleria fowleri. This is the first reported case, to our knowledge, in Missouri. Emphasis is placed on the morphologic identification of degenerating amebas in a cytospin preparation of cerebrospinal fluid using Wright's stain during the rapidly progressive meningoencephalitic stage.

Sex differences in plasma concentrations of steroids during the sensitive period for brain differentiation in the zebra finch.

Changes in plasma concentrations of sex steroids were examined in male and female zebra finch chicks during the sensitive period for differentiation of sexually dimorphic brain nuclei associated with the control of song. Using a chromatographic separation procedure and radioimmunoassay, androstenedione, testosterone and 5 alpha-dihydrotestosterone were detected in plasma at relatively high concentrations immediately after hatching. There were no sex differences in concentrations of these androgens.

Miscounting the Spanish origin population in the United States: corrections to the 1970 census and their implications.

"The purpose of this...

The effects of inferotemporal cortex lesions on Konorski delayed pair comparison in monkeys.

Rhesus monkeys were trained on a pair comparison recognition memory task, running concurrently with a signal detection (attention) problem. The animals were given bilateral posterior or anterior inferotemporal cortex lesions once satisfactory performance had been reached. The former group sustained attentional but only transient mnemonic impairments.

Sexual imprinting in male Japanese quail: the effects of castration at hatching.

This study investigated whether gonadal hormones are required for sexual imprinting in male Japanese quail during the period of exposure to the imprinting stimulus. Brown males were either castrated or laparotomized on the day of hatching. Between Days 10 and 30 of age castrated males (N = 15) and intact laparotomized males (N = 10) were exposed individually to white females.

An assay for antigen-antibody complexes in human sera using C1q-enzyme conjugates.

An assay for soluble immune complexes employing enzyme-C1q conjugates is described. The method is sensitive, rapid and precise, and should prove suitable for monitoring patients. The test gave positive results for complexes in normal pregnant women and indicated significantly increased levels in subjects with pre-eclampsia.

Interdisciplinary education for community health: the case for nursing and social work collaboration.

A nurse educator and a social work educator developed an interdisciplinary team-taught course in community health for both social work and nursing students. This account of their experience elaborates the implications of interdisciplinary education for the student learning experience including theory and practice content, socialization, and transition; faculty development; and the larger university community. Although this particular instance is limited to baccalaureate education, the authors underscore the potential of interdisciplinary course work for the enrichment of all levels of nursing and social work education.