Achievement of the patient acceptable symptom state following total shoulder arthroplasty with nonspherical humeral head and inlay glenoid.

Background: Total shoulder arthroplasty (TSA) with a nonspherical humeral head component and inlay glenoid is a bone preserving treatment for glenohumeral arthritis. This study aims to describe minimum two year patient reported outcomes, patient acceptable symptomatic state (PASS) achievement, and complications following TSA with this prosthesis.

Methods: A retrospective review of patients undergoing TSA with nonspherical humeral head and inlay glenoid was performed.

Corrigendum to Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment.

This corrects the article DOI: 10.14573/altex.2212081.

Cleaning practices of transport vehicles by commercial and non-commercial livestock markets users in Scotland.

Background: Livestock markets are critical intermediaries in the movement of cattle and sheep between herds and to abattoirs. Disease prevention strategies promoting Cleansing & Disinfection (C&D) of vehicles moving animals from markets are in place in Scotland to reduce the risk of widespread transmission of pathogens within the livestock industry. However, little is known about how market users implement C&D on their vehicles and how these may differ between sectors of the industry.

Anatomic total shoulder arthroplasty with a nonspherical humeral head and inlay glenoid: 90-day complication profile in the inpatient versus outpatient setting.

Background: Total shoulder arthroplasty (TSA) with a nonspherical humeral head component and inlay glenoid is a successful bone-preserving treatment for glenohumeral arthritis. This study aimed to describe the 90-day complication profile of TSA with this prosthesis and compare major and minor complication and readmission rates between inpatient- and outpatient-procedure patients.

Methods: A retrospective review was performed of a consecutive cohort of patients undergoing TSA with a nonspherical humeral head and inlay glenoid in the inpatient and outpatient settings by a single surgeon between 2017 and 2022.

How accurate are positive preoperative aspiration culture results in shoulder periprosthetic joint infection? A concordance study.

Background: The concordance between preoperative synovial fluid cultures and intraoperative tissue cultures for identifying pathogenic microorganisms in shoulder periprosthetic joint infection (PJI) remains poorly understood. The purpose of our study was to examine the diagnostic accuracy of positive synovial fluid culture results in early pathogen identification for shoulder PJI.

Methods: A total of 35 patients who met the Musculoskeletal Infection Society criteria for PJI following primary anatomic or reverse arthroplasty and the study inclusion criteria were identified retrospectively from a single institution (multiple surgeons) from January 2011 to June 2021.

Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment.

New approach methodologies (NAMs) based on human biology enable the assessment of adverse biological effects of pharmaceuticals and other chemicals. Currently, however, it is unclear how NAMs should be used during drug development to improve human safety evaluation. A series of 5 workshops with 13 international experts (regulators, preclinical scientists, and NAMs developers) was conducted to identify feasible NAMs and to discuss how to exploit them in specific safety assessment contexts.

Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.

Purpose: We evaluated the activity of AZD8205, a B7-H4-directed antibody-drug conjugate (ADC) bearing a novel topoisomerase I inhibitor (TOP1i) payload, alone and in combination with the PARP1-selective inhibitor AZD5305, in preclinical models.

Experimental Design: IHC and deep-learning-based image analysis algorithms were used to assess prevalence and intratumoral heterogeneity of B7-H4 expression in human tumors. Several TOP1i-ADCs, prepared with Val-Ala or Gly-Gly-Phe-Gly peptide linkers, with or without a PEG8 spacer, were compared in biophysical, in vivo efficacy, and rat toxicology studies.

The Current Role of Biologics for Meniscus Injury and Treatment.

Purpose Of Review: There is little doubt that the consensus has changed to favor preservation of meniscal function where possible. Accordingly, the indications for meniscal repair strategies have been refocused on the long-term interest of knee joint health. The development and refinements in surgical technique have been complemented by biological augmentation strategies to address intrinsic challenges in healing capacity of meniscal tissue, with variable effects.

Surgical approach to pediatric mediastinal masses based on imaging characteristics.

Background: Pediatric mediastinal masses may be resected using an open or video-assisted thoracoscopic surgery (VATS) approach. We sought to define the preoperative imaging findings predicting amenability to VATS.

Methods: This multicenter retrospective study of pediatric patients undergoing either VATS or open surgical mediastinal mass resection between 2008 and 2018 evaluated the preoperative imaging descriptors associated with VATS.

Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.

Antibody-drug conjugate (ADC) research has typically focused on the release of highly potent cytotoxic agents to achieve antitumor efficacy. However, recently approved ADCs trastuzumab deruxtecan and sacituzumab govitecan release lower-potency topoisomerase inhibitors. This has prompted interest in ADCs that release lower-potency cytotoxic drugs to potentially enhance therapeutic index and reduce unwanted toxicity.

Fe-Rich Fossil Vents as Mars Analog Samples: Identification of Extinct Chimneys in Miocene Marine Sediments Using Raman Spectroscopy, X-Ray Diffraction, and Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy.

On Earth, the circulation of Fe-rich fluids in hydrothermal environments leads to characteristic iron mineral deposits, reflecting the pH and redox chemical conditions of the hydrothermal system, and is often associated with chemotroph microorganisms capable of deriving energy from chemical gradients. On Mars, iron-rich hydrothermal sites are considered to be potentially important astrobiological targets for searching evidence of life during exploration missions, such as the Mars 2020 and the ExoMars 2022 missions. In this study, an extinct hydrothermal chimney from the Jaroso hydrothermal system (SE Spain), considered an interesting geodynamic and mineralogical terrestrial analog for Mars, was analyzed using Raman spectroscopy, X-ray diffraction, and scanning electron microscopy coupled with energy dispersive X-ray spectroscopy.

Modernizing Medical Research to Benefit People and Animals.

In the context of widespread public and political concern around the use of animals in research, we sought to examine the scientific, ethical and economic arguments around the replacement of animals with New Approach Methodologies (NAMs) and to situate this within a regulatory context. We also analyzed the extent to which animal replacement aligns with British public and policymakers' priorities and explored global progress towards this outcome. The global context is especially relevant given the international nature of regulatory guidance on the safety testing of new medicines.

Pediatric Group A streptococcal spinal epidural abscess presenting with recurrent symptoms of viral illness: An operative case report.

Background: Spinal epidural abscess (SEA) in children is a rare condition with dangerous sequelae, and with only 22 other cases reported in the literature, treatment algorithms are poorly understood. Quick identification of the classic tried of sepsis, back pain and neurological deficit is critical. Source identification difficult and often cannot be identified.

Asymmetric one-dimensional slow electron holes.

Slow solitary positive-potential peaks sustained by trapped electron deficit in a plasma with asymmetric ion velocity distributions are in principle asymmetric, involving a potential change across the hole. It is shown theoretically how to construct such asymmetric electron holes, thus providing fully consistent solutions of the one-dimensional Vlasov-Poisson equation for a wide variety of prescribed background ion velocity distributions. Because of ion reflection forces experienced by the hole, there is generally only one discrete slow hole velocity that is in equilibrium.

Quantitative analysis of binary and ternary organo-mineral solid dispersions by Raman spectroscopy for robotic planetary exploration missions on Mars.

The Mars 2020 and ExoMars 2022, rover-based missions are specifically dedicated to the search for evidence of life and will both utilise Raman spectrometers on the surface of Mars. Raman spectroscopy is indeed a valuable analytical technique for planetary exploration that enables characterisation of rocks and soils collected directly from the surface or retrieved as cores and subsequently crushed when extracted from the subsurface with a drill. On Mars, the miniaturised spectrometers will interrogate ancient geological deposits, in order to try and identify hydrated or aqueously altered minerals and organic matter to assess the habitability of Mars.

Spacecraft Observations and Theoretical Understanding of Slow Electron Holes.

We present Magnetospheric Multiscale observations showing large numbers of slow electron holes with speeds clustered near the local minimum of double-humped velocity distribution functions of background ions. Theoretical computations show that slow electron holes can avoid the acceleration that otherwise prevents their remaining slow only under these same circumstances. Although the origin of the slow electron holes is still elusive, the agreement between observation and theory about the conditions for their existence is remarkable.

How can slow plasma electron holes exist?

One-dimensional analysis is presented of solitary positive potential plasma structures whose velocity lies within the range of ion distribution velocities that are strongly populated: "slow" electron holes. It is shown that to avoid the self-acceleration of the hole velocity away from ion velocities it must lie within a local minimum in the ion velocity distribution. Quantitative criteria for the existence of stable equilibria are obtained.

Myocarditis and Pericarditis After Vaccination for COVID-19.

This study investigates the incidence of myocarditis and pericarditis emergency department or inpatient hospital encounters before COVID-19 vaccine availability (January 2019–January 2021) and during a COVID-19 vaccination period (February-May 2021) in a large US health care system.

Patellar Fracture Fixation With Cannulated Compression Screws and FiberTape Cerclage.

Transverse patella fractures with loss of knee extensor mechanism function are a common orthopaedic injury requiring operative fixation. Current accepted surgical options for noncomminuted transverse fractures include open reduction with tension band wiring. Although these procedures result in good clinical outcomes and fracture healing, symptomatic hardware from the historically used metal implants is very common.

Effect of Vancomycin Soaking on Anterior Cruciate Ligament Graft Biomechanics.

Purpose: To evaluate the effect of soaking of anterior cruciate ligament (ACL) grafts in vancomycin solution on graft biomechanical properties at the time of implantation.

Methods: The central third of patellar tendons was harvested from mature bovine knees and prepared as a tendon-only graft or a bone-tendon-bone (BTB) graft. Tendons were wrapped in gauze soaked in vancomycin solution (VS) (5 mg/mL) or normal saline (NS) and left to stand for 30 minutes at room temperature, simulating graft exposure times in the operating room during ACL reconstruction.