Burnout Among Primary Healthcare Nurses: A Study of Association With Depression, Anxiety and Self-Efficacy.

Burnout is a significant issue among healthcare professionals, particularly nurses, due to high workloads and emotional demands. However, limited research has explored burnout among primary healthcare nurses in Saudi Arabia, who play a vital role in healthcare delivery. This study aims to address this gap by investigating burnout levels and their association with anxiety, depression and self-efficacy among primary healthcare nurses.

Effect of mindfulness training program on well-being and leadership skills of psychiatric nurses.

Background: Nursing leaders need mindfulness, which is an effective intervention for reducing stress, promoting well-being, and enhancing their leadership skills.

Purpose: To explore the effect of a mindfulness training program on the well-being and leadership skills of head nurses.

Methods: A quasi-study design was used and conducted in a psychiatric and neurological university hospital on a convenience sample of 40 head nurses.

Cornulacin: a new isoflavone from and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis.

Chemical investigation of the methanolic extract of (Amaranthaceae), an annual wild herb collected from North Sinai, Egypt, yielded a new isoflavone cornulacin 1 and five known compounds: -feruloyltyramine 2, -feruloyl-3'-methoxytyramine 3, -caffeoyl tyramine 4, Cannabisin F 5 and (2a, 3a) lyciumamide D 6. Using MTT assay, the isolated compounds were evaluated for their cytotoxicity against pancreatic (Panc1) and ovarian (A2780) cancer cell lines. Compounds 1, 2, 3, and 4 exhibited promising cytotoxic activity against the tested cells, among which compound 1 (IC of 2.

Estrogen Receptor Alpha Binders for Hormone-Dependent Forms of Breast Cancer: e-QSAR and Molecular Docking Supported by X-ray Resolved Structures.

Cancer, a life-disturbing and lethal disease with a high global impact, causes significant economic, social, and health challenges. Breast cancer refers to the abnormal growth of cells originating from breast tissues. Hormone-dependent forms of breast cancer, such as those influenced by estrogen, prompt the exploration of estrogen receptors as targets for potential therapeutic interventions.

Artificial intelligence system for automatic maxillary sinus segmentation on cone beam computed tomography images.

Objectives: The study aims to develop an artificial intelligence (AI) model based on nnU-Net v2 for automatic maxillary sinus (MS) segmentation in cone beam computed tomography (CBCT) volumes and to evaluate the performance of this model.

Methods: In 101 CBCT scans, MS were annotated using the CranioCatch labelling software (Eskisehir, Turkey) The dataset was divided into 3 parts: 80 CBCT scans for training the model, 11 CBCT scans for model validation, and 10 CBCT scans for testing the model. The model training was conducted using the nnU-Net v2 deep learning model with a learning rate of 0.

Effect of melatonin on reproductive function in propylthiouracil induced hypothyroidism in adult male rats.

Objective: Thyroid hormones are essential for regulating metabolism, reproduction, and growth. Hypothyroidism is connected with lower sperm count and motility, leading to male infertility. Oxidative stress is likely to be linked to this interaction.

The impact of health volunteering of radiology students on improving their self-skills and practical capabilities in the Kingdom of Saudi Arabia.

Background: Volunteering is a beneficial activity with a wide range of positive outcomes, from the individual to the communal level. In many ways, volunteering has a positive impact on the development of a volunteer's personality and experience. This study aimed to evaluate the impact of health volunteering on improving the self-skills and practical capacities of students in the western region of the Kingdom of Saudi Arabia.

efficacy of resin extracts formulated as an emulsifiable concentrate against and phytopathogenic fungi.

Contemporary agriculture heavily relies on pesticides for pest eradication and disease management. Consequently, current study was carried out to assess the acaricidal/antifungal efficacy of emulsifiable concentrate (10 % EC) derived from () against adult females of (), and five fungal pathogens. The meticulous examination of the chemical constitution of the crude extracts derived from the resin of was conducted through the employment of the venerable technique known as Gas-Liquid Chromatography (GLC).

SGLT-2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat PCOS model.

Polycystic ovary syndrome (PCOS) is a common endocrine, reproductive, and metabolic disorder affecting females. The management of PCOS is challenging and current interventions are not enough to deal with all consequences of this syndrome. We explored the beneficial effect of combined sodium glucose co transporter-2 inhibitor (SGLT-2i); (empagliflozin) and metformin on hormonal and metabolic parameters in an animal model of PCOS and insulin resistance (IR).

Appraisal of surface-groundwater anthropogenic indicators and associated human health risk in El Sharqia Governorate, Egypt.

The aim of this study was to integrate hydrogeochemistry with a multivariate statistical approach to understand the various processes that control the evolution/contamination of water resources in El Sharqia Governorate, Egypt with a particular emphasis on direct/indirect risks to human health. To achieve this, a representative collection of 21 groundwater and 35 drainage samples was taken and examined for physical, chemical, and trace element measurements. Results indicated that in shallow groundwater and drainage water samples, the relative abundance of major cations is Na > Mg > Ca > K, and for anions it is HCO > Cl > SO (on a molar basis).

Integration of groundwater vulnerability with contaminants transport modeling in unsaturated zone, case study El-Sharqia, Egypt.

Nowadays, irrigation uses large amount of marginal wastewater due to continuous decline in fresh water supply. As a consequence, using this wastewater for different purposes can cause some adverse environmental impacts. Anthropogenic activities such as septic tanks, sewage ponds, and polluted drains have large influence on deterioration of shallow groundwater aquifers.

Assessment of Lower Limb Deep Vein Thrombosis: Characterization and Associated Risk Factors Using Triplex Doppler Imaging.

Background: Deep vein thrombosis (DVT) is a common health problem. Accurate diagnosis of DVT is essential to avoid potentially fatal acute consequences of pulmonary embolism.

Aim: The study aims to assess deep venous thrombosis (DVT) of the lower limbs and to analyze the related risk factors.

Evaluation of the Fungicidal Effect of Some Commercial Disinfectant and Sterilizer Agents Formulated as Soluble Liquid against Infected Tomato Plant.

Globally, root rot disease of tomato plants caused by is a severe disease leading to the death of infected plants. The effect of some commercial antiseptics and disinfectant agents, such as chloroxylenol (10%), phenic (10%) and formulated phenol (7%) on the control of root rot pathogen and its impact on growth and chemical constituents of tomato seedlings cv. Castle Rock were investigated in vitro and in vivo.

Tracking anthropogenic nitrogen-compound sources of surface and groundwater in southwestern Nile Delta: hydrochemical, environmental isotopes, and modeling approach.

This research aims to assign the specific and potential sources that control migration and transformation mechanisms of ammonium/nitrate contaminants of surface and groundwater systems in the southwestern Nile Delta, Egypt. To achieve that, an integration of hydrogeochemistry, multiple environmental stable isotopes (δH-HO, δO-HO, δN-NH, and δN-NO) coupled with three-dimensional nitrogen transport numerical model (MODFLOW-MT3D) was done. A set of representative water samples (20 canals and drainage water) and 14 groundwater samples were collected and analyzed for physical, chemical, and stable isotope analysis.

Pattern of novel psychoactive substance use among patients presented to the poison control centre of Ain Shams University Hospitals, Egypt: A cross-sectional study.

Background: Novel psychoactive substances (NPSs) are relatively new substances in the illicit drug market, not previously listed in the United Nations Office on Drugs and Crime (UNDOC). Strox and Voodoo are considered some of the most popular blends of NPS in the Egyptian drug market.

Objectives: The current study was conducted to assess NPS's use pattern: Voodoo and Strox among acutely intoxicated patients presented to the poison control center of Ain Shams University Hospitals (PCC- ASUH).

Voluntary testing for COVID-19: perceptions and utilization among the inhabitants of Saudi Arabia.

Objectives: Voluntary testing (VT) plays a crucial role in the prevention and control of infectious diseases. The present study investigated the perceptions and utilization of VT services for coronavirus disease 2019 (COVID-19) among the inhabitants of Saudi Arabia.

Methods: In total, 3,510 adult participants from all provinces of Saudi Arabia were recruited via a national online survey.

Site-directed mutagenesis of Serine-72 reveals the location of the fructose 6-phosphate regulatory site of the Agrobacterium tumefaciens ADP-glucose pyrophosphorylase.

The allosteric regulation of ADP-glucose pyrophosphorylase is critical for the biosynthesis of glycogen in bacteria and starch in plants. The enzyme from Agrobacterium tumefaciens is activated by fructose 6-phosphate (Fru6P) and pyruvate (Pyr). The Pyr site has been recently found, but the site where Fru6P binds has remained unknown.

A Comparative Study between Postoperative Analgesia of Fascia Iliaca Compartment Block and Anterior Quadratus Lumborum Block in Proximal Femur Fracture.

Elderly patients with various comorbidities are more likely to suffer from proximal femur fractures. It is also a painful fracture, and poor pain management can have serious physiological and psychological consequences, such as acute delirium. .

GIPR gene expression in testis is mouse specific and can impact male mouse fertility.

Background: Glucose-dependent insulinotropic polypeptide receptor (Gipr) gene expression has been reported in mouse spermatids and Gipr knockout male mice have previously been reported to have decreased in vitro fertilization, although the role of Gipr signaling in male mouse fertility is not well understood.

Objectives: The purposes of these studies were to determine the role of glucose-dependent insulinotropic polypeptide receptor in male fertility using Gipr knockout mice and anti-glucose-dependent insulinotropic polypeptide receptor antibody-treated wild-type mice and to determine if the expression of Gipr in mouse testes is similar in non-human and human primates.

Methods And Materials: Adiponectin promoter-driven Gipr knockout male mice (Gipr ) were assessed for in vitro and in vivo fertility, sperm parameters, and testicular histology.

The Role of MRI Pancreatic Protocol in Assessing Response to Neoadjuvant Therapy for Patients With Borderline Resectable Pancreatic Cancer.

Background: Borderline Resectable Pancreatic Cancer (BRPC) remains a unique entity that is difficult to categorize due to variance in definitions and the small number of patients. The ultimate goal is to achieve a free resection (R0) after a favorable response to neoadjuvant therapy that is somewhat difficult to assess by current radiological parameters.

Aim: To evaluate the role of Magnetic Resonance Imaging (MRI) pancreatic protocol, including Diffusion-Weighted Imaging (DWI), in patients with BRPC receiving neoadjuvant therapy, and further compare it to RECIST criteria and outcome.

Psychological distress related to the emerging COVID-19 pandemic and coping strategies among general population in Egypt.

Background: Psychological distress is considered a threat to the mental health of human beings. This research was conducted at the beginning of the emerging COVID-19 pandemic, when most people had limited knowledge about coronavirus, mode of transmission, associated manifestations, with uncertainty about treatment, vaccine, future life, and coping capacity. This study examined the nature of the psychological distress related to the emergence of the coronavirus disease 2019 (COVID-19) pandemic and coping strategies adopted among the general population in Egypt.

Identification of 'Voodoo': an emerging substance of abuse in Egypt.

Background: 'Voodoo' is a new substance of abuse that recently spread among youth in Egypt. It has numerous potentially dangerous effects on humans. However, to date the composition of the main constituents of this compound is unknown.

Hexosomal Dispersion: A Nano-Based Approach to Boost the Antifungal Potential of Citrus Essential Oils against Plant Fungal Pathogens.

The demand for natural fungicides to replace synthetic ones has surged since toxic residues persist in soils, causing environmental contamination and posing a serious threat to worldwide public health. In the context of crop protection and enhancing the efficiency and safety of fungicides, nanotechnology is an eco-friendly strategy in managing fungal pathogens. In the present study, essential oils were isolated from the peels of four citrus fruits (, , , and ) and were investigated using gas chromatography-mass spectrometric analysis.