Lung disease associated with filamin A gene mutation: a case report.

Background: Mutations in the gene encoding filamin A (FLNA) lead to diseases with high phenotypic diversity including periventricular nodular heterotopia, skeletal dysplasia, otopalatodigital spectrum disorders, cardiovascular abnormalities, and coagulopathy. FLNA mutations were recently found to be associated with lung disease. In this study, we report a novel FLNA gene associated with significant lung disease and unique angiogenesis.

Associations between spontaneous preterm birth and maternal-newborn ABO blood phenotype pairs.

Objective: To study whether spontaneous preterm birth (SPB) is associated with maternal-newborn ABO blood phenotype pairs.

Methods: We conducted a retrospective case-control study in the Department of Pediatrics, King Abdulaziz Hospital, Al-Ahsa, Kingdom of Saudi Arabia. A total of 631 live singleton SPBs (less than 37 weeks) between August 2005 and May 2011 formed the case group.