Publications by authors named "Hussein Metwally"

Background: Total neoadjuvant therapy (TNT) before surgical intervention represents a unique therapeutic approach for the management of locally advanced rectal cancer (LARC) and has witnessed a notable rise in utilization within recent years. However, the efficacy and safety of this treatment remain subjects of ongoing debate and investigation. This randomized controlled trial aimed to evaluate the potential impact of administering induction chemotherapy (IC) before the conventional neoadjuvant concomitant chemoradiotherapy (nCRT) in LARC patients.

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Article Synopsis
  • Early diagnosis and proper management of epilepsy are crucial, yet Egypt faces significant challenges in healthcare practices, leading to poor outcomes for patients.
  • A group of Egyptian experts used a modified Delphi method to develop a nationwide consensus on epilepsy diagnosis and treatment after reviewing recent literature and guidelines.
  • Out of 278 statements discussed, a strong agreement was reached on 256, aiming to enhance the quality of care and improve treatment outcomes for those living with epilepsy in Egypt.
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Purpose: To assess the interobserver variability in clinical target volume (CTV) definitions when using registered (18)F-labeled deoxyglucose positron emission tomography (FDG-PET-CT) versus side-by-side image sets in pediatric Hodgkin's disease (HD).

Methods And Materials: Prechemotherapy FDG-PET-CT scans performed in the treatment position were acquired from 20 children (median age, 14 years old) with HD (stages 2A to 4B) and registered with postchemotherapy planning CT scans. The patients had a median age of 14 years and stages of disease ranging between 2A and 4B.

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