Ontology-based clinical information extraction from physician's free-text notes.

Documenting clinical notes in electronic health records might affect physician's workflow. In this paper, an Ontology-based clinical information extraction system, OB-CIE, has been developed. OB-CIE system provides a method for extracting clinical concepts from physician's free-text notes and converts the unstructured clinical notes to structured information to be accessed in electronic health records.

Clinical implications of proteolytic activity imbalance in breast cancer diagnosis.

Background: Matrix metalloproteinase-9 and its tissue inhibitor TIMP-1 have been documented as putative tumor markers because of their involvement in cancer invasion and metastasis.

Objective: The aim of our study was to elucidate the diagnostic efficacy of proteolytic activity markers among traditional tumor markers (CEA and CA15.3) and clinicopathological variables.