Publications by authors named "Hussein A Rajab"
Article Synopsis
- Vascular dementia (VaD) is the second most common type of dementia after Alzheimer’s disease, characterized by cognitive impairment and memory loss, often linked to cerebral amyloid angiopathy (CAA).
- Early diagnosis and the use of anti-inflammatory treatments can potentially prevent the development of VaD, but there are currently no effective drugs available specifically for its management.
- Statins, commonly used for lowering cholesterol, may show promise in treating VaD and improving cognitive function, but the exact mechanisms of their effectiveness are still not well understood.
The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase.
Diagnostics (Basel)
November 2022
Over the years, we have noticed in our clinical practice that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL are more symptomatic than those with higher levels. The aim of this research is to investigate changes in both parathyroid hormone (PTH) and alkaline phosphatase (ALP) at different vitamin D levels to determine if lower vitamin D levels are associated with more severe changes in PTH and ALP, which may explain the presence and severity of symptoms at those lower 25OHD levels. We looked for correlations between 25OHD level, PTH, and ALP in 1311 samples between 2015 and 2019 at our endocrine clinic to determine if vitamin D level correlates with changes in PTH and ALP.
View Article and Find Full Text PDFImmune complexes (IC) containing predominantly malondialdehyde-LDL and the corresponding autoantibodies (MDA-LDL IC) predict acute cardiovascular events, while IC rich in oxidized LDL (oxLDL IC) predict cardiovascular disease progression. Our objective was to determine mechanisms that could explain these prognostic differences. We compared the effects of the interaction of oxLDL, MDA-LDL and the corresponding IC with human macrophages focusing on apoptosis, metalloproteinases, and proinflammatory cytokines.
View Article and Find Full Text PDFAims: This study was undertaken to determine whether levels of inflammation and endothelial dysfunction biomarkers in serum samples collected at baseline in the Diabetes Control and Complications Trial (DCCT) cohort could predict the development of retinopathy.
Methods: Levels of clotting/fibrinolysis, inflammation and endothelial dysfunction biomarkers were measured in 1391 subjects with type 1 diabetes to determine whether their levels predicted increased risk to develop or accelerate progression of retinopathy during 16years of follow-up.
Results: Using regression models adjusted for DCCT treatment group, duration of diabetes, baseline retinopathy scores, HbA1c and albumin excretion rate, the baseline levels of sE-selectin and PAI-1 (active) were significantly associated with increased risk of a 3-step progression in retinopathy score in the primary prevention cohort (PPC).