Sitagliptin ameliorates the progression of atherosclerosis via down regulation of the inflammatory and oxidative pathways.

Back Ground: Atherosclerosis is the major cause of death. The most common risk factors are hyperlipidemia, diabetes, and other factors like chronic infection and inflammation.

Objective: This study was undertaken to assess the effect of sitagliptin on atherosclerosis via interfering with inflammatory and oxidative pathways.