Publications by authors named "Hussam Askar"
Chemopreventive effect of Pistacia vera leaf extract against mammary carcinoma induced by dimethyl-benz(a)anthracene in vivo and in vitro: Potential role of antioxidant, antiinflammatory and immune mechanisms.
Food Chem Toxicol
January 2025
This study aimed to define the antitumor effect of ethanolic extract of Pistacia vera leaves (PEE) toward breast cancer both in vitro and in vivo using dimethyl-benz(a)anthracene (DMBA)-induced breast tumor in adult female rats. PEE showed a potent antioxidant effect toward both DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicals with IC values of 72.6 and 107.
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- The study explored how hesperidin affects hormonal regulation and inflammation in hyperthyroid female rats.
- It involved four groups: a control group, a hesperidin-treated healthy group, a hyperthyroid group with no treatment, and a treated hyperthyroid group.
- Results showed that hesperidin improved thyroid function, reduced inflammation markers, enhanced antioxidant levels, and exhibited protective effects on kidney and liver health.
Article Synopsis
- Parasitic infestations, particularly from Paramphistomes, pose a significant threat to the livestock industry in Pakistan, adversely affecting the productivity of domesticated ruminants.
- This study aimed to fill the gap regarding mitochondrial DNA characterization of Paramphistomes in Pakistan by analyzing samples obtained from small ruminants at an abattoir in Faisalabad, using various molecular and statistical methods.
- Findings revealed a high prevalence of infection correlated with factors like deworming practices, seasonality, and grazing habits, indicating a need for further research on the distribution and population dynamics of these parasites in livestock.
One of the most common tumors to cause death worldwide is colon cancer. This study aims to investigate the antitumor potency of sp. methanolic extract (LME) against DMH-induced colon cancer in adult male rats.
View Article and Find Full Text PDFHuman SARS-CoV-2 and avian infectious bronchitis virus (IBV) are highly contagious and deadly coronaviruses, causing devastating respiratory diseases in humans and chickens. The lack of effective therapeutics exacerbates the impact of outbreaks associated with SARS-CoV-2 and IBV infections. Thus, novel drugs or therapeutic agents are highly in demand for controlling viral transmission and disease progression.
View Article and Find Full Text PDFcauses various chronic inflammatory diseases, including mastitis and bronchopneumonia, in dairy and feed cattle. It has been found to suppress the host immune response during infection, leading to the development of chronic conditions. Both in vitro and in vivo studies have confirmed that can induce proinflammatory cytokines and chemokines in the host.
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