Effect of silkworm pupae meal on the growth of Oreochromis niloticus (Cichliformes: Cichlidae)(Order: Cichliformes, Family: Cichlidae)CichliformesCichlidae.

Increasing costs and limited supply of fishmeal make fish feed more expensive. Pupa of the silkworm (Bombyx mori L.), a byproduct of the sericulture industry is a cheap and sustainable alternative to fish meal.

GPCR dimerization: Drug discovery aspects and targets in renin-angiotensin systems.

G protein-coupled receptors (GPCRs), which play crucial roles in various physiological functions, often assembled into dimers and higher-order oligomers. This oligomerization phenomenon has been observed in diverse physiological and pathological contexts, presenting promising opportunities for drug discovery targeting vital systems such as the cardiovascular, nervous, endocrine, and renal systems. This review offers a concise understanding of GPCR dimerization, its signaling mechanisms, and its implications.

Deep Learning-based Aligned Strain from Cine Cardiac MRI for Detection of Fibrotic Myocardial Tissue in Patients with Duchenne Muscular Dystrophy.

Purpose To develop a deep learning (DL) model that derives aligned strain values from cine (noncontrast) cardiac MRI and evaluate performance of these values to predict myocardial fibrosis in patients with Duchenne muscular dystrophy (DMD). Materials and Methods This retrospective study included 139 male patients with DMD who underwent cardiac MRI examinations at a single center between February 2018 and April 2023. A DL pipeline was developed to detect five key frames throughout the cardiac cycle, and respective dense deformation fields, allowing for phase-specific strain analysis across patients and from one key frame to the next.

Particle size-based evaluation of stormwater control measures in reducing solids, polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs).

This study evaluates the effectiveness of various stormwater control measures (SCMs) in removing polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs), both in dissolved forms and associated with different-sized solids. The SCMs evaluated include biofilters, a hybrid biofilter + media filter, a retention pond, and treatment trains with hydrodynamic separators and cartridge filters. The targeted particle size fractions were clay (0.

The microbiome-restorative potential of ibezapolstat for the treatment of infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae.

Ibezapolstat (IBZ), a first-in-class antibiotic targeting the PolC-type DNA polymerase III alpha-subunit (PolC) in low G + C bacteria, is in clinical development for the treatment of infection (CDI). In the phase 2 trials, IBZ had potent activity against while sparing or causing regrowth of Lachnospiraceae, Oscillospiraceae, and Erysipelotrichales, common commensal low G + C bacteria. The purpose of this study was to utilize approaches to better interpret the narrower than expected IBZ spectrum of activity.

Therapeutic Potential of PRMT1 as a Critical Survival Dependency Target in Multiple Myeloma.

Multiple myeloma (MM) is a neoplasm of antibody-producing plasma cells and is the second most prevalent hematological malignancy worldwide. Development of drug resistance and disease relapse significantly impede the success of MM treatment, highlighting the critical need to discover novel therapeutic targets. In a custom CRISPR/Cas9 screen targeting 197 DNA damage response-related genes, Protein Arginine N-Methyltransferase 1 (PRMT1) emerged as a top hit, revealing it as a potential therapeutic vulnerability and survival dependency in MM cells.

Interactions between ADGRF1 (GPR110) and extracellular matrix proteins govern its effects on tumorigenesis in HER2-positive breast cancer.

Background And Purpose: We and others have previously shown that ADGRF1, an adhesion G protein-coupled receptor, is overexpressed and associated with poor survival in many cancers, including human epidermal growth factor receptor-2 (HER2) breast cancer (BC). Also, we have reported the tumour-promoting function of ADGRF1 using preclinical models of HER2+ BC. In this study, we investigated the effect of ADGRF1 overexpression in an orthotopic in vivo model as well as downstream signalling of ADGRF1 in HER2+ BC.

Cerebrovascular Disease and Late-Life Depression: A Scoping Review.

Cerebral small-vessel disease (CSVD) is an umbrella term encompassing chronic, progressive conditions that affect the brain's vasculature. Diverse pathological and neurological factors lead to various clinical and neuroimaging patterns in elderly patients. While depression in the elderly is not uncommon, the connection between CSVD and late-life depression (LLD) remains unclear.

Communication Tapestry: Health Literacy Mediates Public Trust in Physician Health Information in Pakistani Public Hospitals.

Background/objectives: This study explores the multifaceted factors influencing public trust in healthcare services provided by doctors in public hospitals in Pakistan. The objective is to examine the relationships between various determinants such as doctors' reputation and expertise, patient participation in decision-making, communication clarity, health literacy levels, and trust in prescribed medications to provide actionable insights for improving healthcare trust.

Methods: A total of 550 patients from public hospitals were surveyed, and data were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM).

Particle swarm optimization based analysis to unlocking the neutrino mass puzzle using [Formula: see text] flavor symmetry.

New research has highlighted a shortfall in the Standard Model (SM) because it predicts neutrinos to have zero mass. However, recent experiments on neutrino oscillation have revealed that the majority of neutrino parameters indeed indicate their significant mass. In response, scientists are increasingly incorporating discrete symmetries alongside continuous ones for the observed patterns of neutrino mixing.

Genetic characterization and phylogenetic analysis of common house crows (Corvus splendens).

The Common House Crow (Corvus splendens) exhibits remarkable ecological adaptability, enabling its rapid expansion across continents. However, despite its wide distribution, there is a need for genetic studies to clarify its evolutionary history and population structure. This research employs DNA barcoding, focusing on the mitochondrial gene cytochrome oxidase subunit I (Cox1), which is effective for species identification and phylogenetic analysis.

Impact of federal funding for graduate medical education on residency program size: Evidence from the Affordable Care Act.

Primary care and rural physician shortages are a present and growing concern to policy makers. We assessed three Affordable Care Act (ACA) provisions that changed the maximum number of residents teaching hospitals could be reimbursed for, an element of graduate medical education (GME) funding known as the resident cap. The results show that an increase in a hospital's resident cap of one slot under one of these ACA provisions in 2010 is associated with an increase in residency program size of approximately one full-time equivalent resident.

Observation of Λ_{c}^{+}→Λa_{0}(980)^{+} and Evidence for Σ(1380)^{+} in Λ_{c}^{+}→Λπ^{+}η.

Based on 6.1  fb^{-1} of e^{+}e^{-} annihilation data collected at center-of-mass energies from 4.600 to 4.

Test of Lepton Universality and Measurement of the Form Factors of D^{0}→K^{*}(892)^{-}μ^{+}ν_{μ}.

One of the main goals of studying semileptonic decays in flavor physics is to gain a better understanding of hadronic transitions in the nonperturbative region of Quantum Chromodynamics. This involves measuring Cabibbo-Kobayashi-Maskawa matrix elements, understanding form factors, and comparing them with theoretical predictions. We report a first study of the semileptonic decay D^{0}→K^{-}π^{0}μ^{+}ν_{μ} by analyzing an e^{+}e^{-} annihilation data sample of 7.

Study of D_{s}^{+}→f_{0}(980)ρ^{+} and ϕπ^{+} Decays through D_{s}^{+}→π^{+}π^{+}π^{-}π^{0}.

We perform the first amplitude analysis of D_{s}^{+}→π^{+}π^{+}π^{-}π^{0} decays based on data samples of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, corresponding to an integrated luminosity of 7.

Enhanced NH and NO sensing performance of TiCO MXene by biaxial strain: insights from first-principles calculations.

In this study, we investigate the adsorption properties of CO, NH, and NO gases on TiCO MXene surfaces through density functional theory (DFT) calculations. A comprehensive analysis of the adsorption preferences, electronic properties, work function (), sensitivity (), and recovery time () was conducted, focusing on the effects of biaxial strain () ranging from -2% to 4%. At free strain, toxic gases can adsorb onto the TiCO surface, with adsorption energies () of -0.

Artificial intelligence for image recognition in diagnosing oral and oropharyngeal cancer and leukoplakia.

Visual diagnosis is one of the key features of squamous cell carcinoma of the oral cavity (OSCC) and oropharynx (OPSCC), both subsets of head and neck squamous cell carcinoma (HNSCC) with a heterogeneous clinical appearance. Advancements in artificial intelligence led to Image recognition being introduced recently into large language models (LLMs) such as ChatGPT 4.0.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

Yeast Eukaryotic Initiation Factor 4B Remodels the MRNA Entry Site on the Small Ribosomal Subunit.

Eukaryotic Initiation Factor 4 (eIF4) is a group of factors that activates mRNA for translation and recruit 43S preinitiation complex (PIC) to the mRNA 5' end, forming the 48S PIC. The eIF4 factors include mRNA 5' cap-binding protein eIF4E, ATP-dependent RNA helicase eIF4A, and scaffold protein eIF4G, which anchors eIF4A and eIF4E. Another eIF4 factor, eIF4B, stimulates the RNA helicase activity of eIF4A and facilitates mRNA recruitment.

Effect of resveratrol on post-thaw motility, kinematics, structural parameters and antioxidant/oxidant status of Kamori buck spermatozoa.

Resveratrol is a polyphenol compound showing strong antioxidant properties. It is believed that semen cryopreservation causes significant sperm losses which eventually affects sperm quality. Improving antioxidant status of semen may reduce this damage and enhance sperm fertilizing potential.

Proposed resources required for a comprehensive program for CCT CHD imaging.

Background: Cardiac Computed Tomography (CCT) is increasingly used for evaluation of congenital heart disease (CHD) in patients of all ages. Pediatric and adult congenital heart disease (ACHD) surgical programs require high quality CCT imaging as part of the multimodality imaging support expected of comprehensive care centers. Despite these expectations, there are no benchmarks or defined programmatic elements specific to the performance of CCT in patients with CHD.

Assessment of salicylic acid and potassium nitrate to mitigate frost stress in autumn-sown potato crop cv. Sutlej.

Potato is cultivated all the year round in Pakistan. However, the major crop is the autumn crop which is planted in mid-October and contributes 80-85% of the total production. The abrupt climate change has affected the weather patterns all over the world, resulting in the reduction of the mean air temperature in autumn by almost 1.

Antiseizure Medications in Poststroke Seizures: A Systematic Review and Network Meta-Analysis.

Background And Objectives: The most effective antiseizure medications (ASMs) for poststroke seizures (PSSs) remain unclear. We aimed to determine outcomes associated with ASMs in people with PSS.

Methods: We systematically searched electronic databases for studies on patients with PSS on ASMs.