Publications by authors named "Hussain Alhawaj"
Background And Objective: Non-obstructive azoospermia (NOA) is an important cause of male infertility. This study is being proposed to assess the efficacy of autologous bone marrow-derived mesenchymal stem cells (MSCs) in the reversal of busulfan-induced NOA in rats.
Methods: Twenty adult 3-month-old male rats were divided into two groups: a control group and a study group.
A crosstalk between 'osteocyte lacunal-canalicular system' and metabolism.
Adv Protein Chem Struct Biol
July 2024
Article Synopsis
- The study emphasizes the significant role of osteocytes (Ots), which make up 95% of bone cells and act as endocrine cells, in understanding bone physiology and its impact on metabolism.
- Experiments conducted on adult male mice revealed a complex interconnection between the osteocyte network and metabolic parameters, using techniques like scanning electron microscopy to analyze bone morphology.
- Findings suggest that understanding the relationship between osteocytes, insulin, and lipid metabolism could lead to new strategies for managing bone and metabolic diseases.
Aim: Radiotherapy is associated with cell depletion and loss of blood supply, which are linked to compromised bone healing. However, the molecular events underlying these effects at the tissue-implant interface have not been fully elucidated. This study aimed to determine the major molecular mediators associated with compromised osseointegration due to previous exposure to radiation.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to evaluate how alopecia affects quality of life, self-esteem, and depression among individuals in Saudi Arabia's Eastern Province.
- A total of 231 participants completed a questionnaire assessing their sociodemographic data, type of alopecia, and mental health metrics, revealing that nearly half had hereditary baldness and many reported high depression levels.
- Findings indicate that factors such as younger age, being female, and hereditary baldness correlate with increased depression and lower quality of life, emphasizing the need for psychological support for those affected.
Background: Renin-angiotensin system and its ACE2/Ang(1-7)/Mas receptor axis regulates skeletal response to multiple physiological and pathological conditions. Recent research suggested a vital role of Ang(1-7) in regulating alveolar bone metabolism and remodeling. In this context, this study evaluated the effects of the Ang(1-7)/Mas receptor axis on orthodontic tooth movement (OTM) and the alveolar bone response to mechanical load.
View Article and Find Full Text PDFObjective: To determine the impact of heat exposure of different sealers on inflammatory cytokine secretions and tissue response in vivo.
Materials And Methods: Silicone tubes were prefilled with epoxy resin (ER) or calcium silicate (CS) sealers, preheated at 37, 60, or 120 °C, and implanted in rat subcutaneous site. Peri-implant exudate and tissue were analyzed after 1 and 4 weeks for cytokine secretions and tissue organization.
Background: Obesity is a global pandemic that is associated with high morbidity and mortality. Natural herbs are commonly used for weight reduction and appetite suppression. Therefore, we aim to investigate the role and mechanism of (NS) and ginger on weight reduction and appetite regulation.
View Article and Find Full Text PDF() has been identified as a group-1 definite carcinogen. As of yet, there is no available vaccine for this microorganism. Our study aimed to identify antigenic peptides in using an in silico proteomic approach, and to evaluate their effectiveness as potential vaccine candidates.
View Article and Find Full Text PDFBackground: Animal models of blood cancer are important tools to study these malignancies and also screen for novel therapeutic agents. Evidence from past research on the carcinogenic properties of 7,12-dimethylbenz[a]-anthracene (DMBA) was provided by a handful of studies. However, recent literature on DMBA carcinogenic activity and the underlying mechanisms is scarce.
View Article and Find Full Text PDFSeveral factors might influence the duration and efficiency of local anesthesia. This study investigates the effect of habitual caffeine intake on lidocaine action and explores the potential involvement of voltage-gated sodium channels in the interaction effect. Wistar rats were divided into four groups: (i) control (Ctrl), (ii) lidocaine intraplantar injection (LIDO), (iii) habitual caffeine intake (CAF), and (iv) lidocaine intraplantar injection and habitual caffeine intake (LIDO + CAF).
View Article and Find Full Text PDFBackground: Caffeic acid phenethyl ester (CAPE) is a naturally occurring polyphenolic concentrated in propolis of honeybee hives. CAPE has been shown various physiological and pharmacologic properties. The aim of the present study was to investigate the effects of CAPE on proinflammatory markers in growing rats by performing the moderate swimming test.
View Article and Find Full Text PDFRecent studies have shown that ovariectomy-induced osteoporosis in rats can be reversed by infusion of osteoblasts cultured from mesenchymal stem cells (MSCs). This study compares the influence of MSCs, osteoblasts, and exosomes derived from osteoblasts for the treatment of osteoporosis. Osteoporosis was induced in 40 female Sprague Dawley rats by performing ovariectomy.
View Article and Find Full Text PDFPurpose: The effect of chemotherapy on the osseointegration of dental implants has received less interest compared with radiotherapy. Thus, the aim of the current study was to investigate the effect of cisplatin chemotherapy on the osseointegration of dental implants in a rabbit model.
Materials And Methods: Sixteen New Zealand White rabbits were randomly assigned to two groups of treatment of either cisplatin at 2.