Publications by authors named "Huseyin Pehlivanoglu"
US-guided percutaneous ablation of thyroid nodules with LU-MAA (LUTMA) - Feasibility study.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
August 2024
Purpose: The main purpose is to evaluate the safety, and efficacy of Lutetium labeled macroaggregated albumin (LUTMA) ablation of thyroid nodules.
Materials And Methods: Patients with confirmed benign nodules who were not candidate or did not accept surgery were enrolled. Under ultrasonography (USG) guidance, LUTMA which was produced in our department, was administered into the nodules.
Article Synopsis
- The study compares the effectiveness of PET imaging with F-18 DOPA and Ga-68 DOTATATE in detecting recurrences of medullary thyroid cancer (MTC) in patients with elevated calcitonin and/or carcinoembryonic antigen levels.
- FDOPA showed higher sensitivity, specificity, and accuracy compared to TATE, particularly in identifying liver and lymph node metastases, while TATE performed better for skeletal metastases.
- Both imaging techniques are valuable for monitoring MTC patients and can be used together for more comprehensive detection of recurrent disease.
Background: A first-in-human study of [F]-BF3-Cy3-ACUPA, a small-molecule imaging agent that can be unimolecularly both positron emitting and fluorescent, is conducted to determine its safety, biodistribution, radiation dosimetry, feasibility in tumor detection by preoperative positron emission tomography (PET), as well as its intraoperative fluorescence imaging utility in patients with prostate-specific membrane antigen positive (PSMA) tumors.
Methods: Ten patients aged 66 ± 7 years received a 6.5 ± 3.
Objective: Our aim was to assess the diagnostic performance of F-18 fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) in detecting hyperfunctioning parathyroid tissue (HPT) in patients with elevated parathyroid hormone levels with negative or inconclusive conventional imaging results and to compare the findings with those obtained using technetium-99m sestamibi (MIBI) scintigraphy and neck ultrasonography (US).
Materials And Methods: Images of 105 patients with hyperparathyroidism who underwent FCH PET/CT, dual-phase MIBI parathyroid scintigraphy (median interval: 42 days), and neck US were retrospectively analyzed. The gold standard was histopathological findings for 81 patients who underwent parathyroidectomy and clinical follow-up findings in the remaining 24 patients.
A number of different peptides or antibodies have been labeled with Lu and used for clinical imaging and treatment. To our knowledge, Lu had never before been used to label macroaggregated albumin, and our radiopharmacy laboratory at Istanbul University-Cerrahpaşa made a special effort to do so. We present the case of a 43-y-old man whose cystic thyroid nodule was treated with an intranodular injection of Lu-macroaggregated albumin and imaged with SPECT/CT.
View Article and Find Full Text PDFBackground/aim: The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection of bone metastasis in prostate cancer patients.
Materials And Methods: A total of 28 prostate cancer patients with bone scan and PSMA PET/CT performed within 90 days were retrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) for metastasis by two experienced nuclear medicine physicians.
Objective: The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617.
Methods: For this purpose, 7 patients who underwent Lu-177-PSMA therapy were included into the study. The injected Lu-177-PSMA-617 activity ranged from 3.