Comparison of histopathologic findings of initial and recurrent lumbar disc herniation.

Objective: Recurrent lumbar disc hernia (RLDH) is a common and challenging complication after an initial discectomy. This study aimed to investigate the relationship between the histopathologic outcomes of the initial and recurrent disc tissues.

Methods: This study investigated 70 patients who underwent a microdiscectomy and subsequently developed same-level same-side lumbar disc herniation (LDH) recurrence.

Antitumor activity of irinotecan with ellagic acid in C6 glioma cells.

Objective: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cell line.

Methods: A combination of 100 μM ellagic acid and 100 μM irinotecan was applied to rat C6 glioma cells for 24th, 48th, and 72nd h.

Assessment relationship between the femoral artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study.

Study Design: Animal proof of principle study.

Objectives: To investigate neurodegeneration in rabbit L4-dorsal root ganglion (DRG) cells by creating experimental spinal subarachnoid hemorrhage (SAH), we aimed to show the neuronal pathway between L-DRG and femoral artery.

Setting: Ataturk University, Medical Faculty, Animal Laboratory, Erzurum, Turkey.

Morphometric study on the 12th thoracic vertebrae which is most frequently exposed to trauma and the closest vertebra to thoracic aorta.

Background: To describe gender-related differences in the length of the left chord and pedicle at the level of 12th thoracic vertebrae and appropriate length of the screw to be applied so as to decrease the perforation risk of anterior cortex of the corpus and preventable injury of major vascular vessels.

Methods: Axial bone window computed tomography images of T12 vertebral pedicles of 60 patients (30 males and 30 females, age >25 years) without any sign of spinal trauma were obtained and morphometric data were analyzed.

Results: Mean ages of the female (n=30) and male (n=30) patients were 32.

The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions.

Purpose: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions.

Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group.

Determining the Optimal Length and Safety of Pedicle Screws in the T12 Vertebra: A Morphometric Study.

Introduction: Despite the developments in implant technology and imaging methods and the advances in surgical techniques, there are still potential problems and complications of transpedicular screw application. This is a morphometric study to examine the proximity of the T12 vertebra to the thoracic aorta. Our aim was to define the appropriate length of the pedicle screw to be used in the 12 thoracic vertebra, using computed tomography (CT) data.

Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress.

Objective: Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. This study aims to investigate the protective influence of antioxidant () polysaccharides (GLPs) on brain injury in brain-traumatized rats.

Methods: Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height.

Posterior Epidural Migration of a Sequestered Lumbar Intervertebral Disc Fragment.

Aim: Posterior epidural migration of a sequestered lumbar intervertebral disc fragment (PEMSLIDF) is an extremely rare condition published so far only as case reports or small case series (ranging between 2 to 8 cases). Diagnosing this condition is often challenging and the diagnosis is usually made intraoperatively. The affected patients usually suffer cauda equina syndrome (CES).

Evaluation of topical application and systemic administration of rosuvastatin in preventing epidural fibrosis in rats.

Background Context: Epidural fibrosis is a major challenge in spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. One of the most important factors initiating the epidural fibrosis is assumed to be the transforming growth factor-1β (TGF-1β). Rosuvastatin (ROS) has shown to demonstrate preventive effects over fibrosis via inhibiting the TGF-1β.

WITHDRAWN: Riluzole alleviates early neutrophil infiltration, brain oedema and lipid peroxidation in the traumatic brain tissue but does not induce neurotoxicity in non-traumatic brain tissue in rats.

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Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood-brain barrier permeability.

Objective: The overproduction of reactive oxygen species and resultant damage to cellular proteins or lipids of cell membranes and DNA by free radicals are the underlying mechanisms of many neuropathologies. Cyclooxygenase-2 (COX-2) inhibitors have been suggested to be neuroprotective by reducing prostanoid and free radical synthesis, or by directing arachidonic acid metabolism through alternate pathways. This study investigated the putative neuroprotective effect of the COX-2 inhibitor, meloxicam, in a rat model of diffuse brain injury.