Relapsing polychondritis presenting with sero-negative limbic encephalitis.

The presented case highlights a rare instance of relapsing polychondritis (RP) manifesting as seronegative limbic encephalitis, an uncommon neurological complication. A 70-year-old female patient with a history of RP-related inflammation, along with neuropsychiatric symptoms, was diagnosed through multidisciplinary collaboration. Swift administration of steroid therapy, followed by azathioprine, led to remarkable physical and cognitive recovery.

Endocyclophotocoagulation combined with phacoemulsification in surgically naive primary open-angle glaucoma: three-year results.

Objective: To assess the safety and efficacy of endocyclophotocoagulation with phacoemulsification (phaco-ECP) in surgically naive, primary open-angle glaucoma (POAG).

Methods: A retrospective case series of patients undergoing phaco-ECP between 2007 and 2017 at a single centre in London, UK. The primary outcome was intraocular pressure (IOP).

The efficacy of dexamethasone implants following anti-VEGF failure for macular oedema in retinal vein occlusion.

Purpose: To investigate the efficacy of intravitreal dexamethasone implants (DEX) after anti-VEGF failure in retinal vein occlusion macular oedema.

Methods: Retrospective cohort study of DEX implant (0.7 mg) given after anti-VEGF 'failure'.

Cyclo[2]benzimidazole: luminescence turn-on sensing of anions.

Cyclo[2]benzimidazole is a new host for anions that turns on its luminescence up to 150 fold upon binding. Photoexcited cyclo[2]benzimidazole undergoes an efficient non-radiative deactivation through an excited-state intramolecular proton-transfer (ESIPT) mechanism. Upon binding an anion, the ESIPT pathway is blocked, resulting in an increase in the luminescence efficiency.

Sensitive and selective PET-based diimidazole luminophore for Zn(II) ions: a structure-activity correlation.

3-(3-Ethoxymethyl-1H-imidazol-2-yl)-3-(1-ethoxymethyl-1H-imidazol-2-yl)-3H-benzo[de]isochromen-1-one, 4, is a novel photoinduced electron transfer (PET) chemosensor that becomes fluorescent upon binding metal ions and shows a strong preference toward Zn(II) ions. The new bisimidazol PET sensor and its zinc complex were prepared and characterized in terms of their crystal structures, absorption and emission spectra, and orbital energy diagrams. Free 4 is a weakly luminescent species.

Sensitive and selective photoinduced-electron-transfer-based sensing of alkylating agents.

Photoinduced-electron-transfer (PET)-based chemosensing is a very elegant way of reporting the presence of a guest species in solution. This method was successfully applied for the detection of different ionic species, such as cations, anions, and protons. Herein, we report on the application of the PET chemosensing concept for the efficient and selective detection of different alkylating agents.